Study of the expression of cathepsins in histological material from pancreatic lesions
Por:
Martinez, J, Ramon Aparicio, J, Peiro, G, Cabezas, A, Roger, M, Ruiz, F, Company, L and Antonio Casellas, J
Publicada:
1 dic 2016
Resumen:
Background and aims: To assess the expression levels of cathepsins in
malignant and premalignant lesions.
Methods: We retrospectively included patients who underwent pancreatic
surgery on pancreatic solid or cystic masses. The expression of
cathepsin H, L, B and S was determined in both types of samples. Lesions
were divided into three categories: malignant (pancreatic adenocarcinoma
and malignant mucinous neoplasms), premalignant (mucinous neoplasms) and
benign (other lesions).
Results: Thirty-one surgical resection samples were studied. The
expression of cathepsins was significantly higher in malignant lesions
than in premalignant and benign lesions (H 75%, 27%, 37% p = 0.05; L
92%, 36%, 37% p = 0.011; B 83%, 36%, 62% p = 0.069; S 92%, 36%, 25% p =
0.004, respectively).
Conclusions: Cathepsins are overexpressed in histological samples of
malignant lesions compared to premalignant and benign lesions. However,
the expression of cathepsins is similar in both premalignant and benign
lesions.
Filiaciones:
:
Hosp Gen Univ Alicante, Dept Digest Endoscopy, C Pintor Baeza S-N, Alicante 03010, Spain
:
Hosp Gen Univ Alicante, Dept Digest Endoscopy, C Pintor Baeza S-N, Alicante 03010, Spain
:
Hosp Gen Univ Alicante, Dept Anat Pathol, Alicante, Spain
:
Hosp Gen Univ Alicante, Dept Anat Pathol, Alicante, Spain
:
Hosp Gen Univ Alicante, Dept Digest Endoscopy, C Pintor Baeza S-N, Alicante 03010, Spain
:
Hosp Gen Univ Alicante, Dept Digest Endoscopy, C Pintor Baeza S-N, Alicante 03010, Spain
:
Hosp Gen Univ Alicante, Dept Digest Endoscopy, C Pintor Baeza S-N, Alicante 03010, Spain
:
Hosp Gen Univ Alicante, Dept Digest Endoscopy, C Pintor Baeza S-N, Alicante 03010, Spain
gold
|