Sensitisation to mites and other animal-derived home aeroallergens in children and its concordance as a measure of covariation of sensitisation
Por:
Moral, L and Toral, T
Publicada:
1 sep 2016
Resumen:
Background: Sensitisation to home aeroallergens (mites, furry animals
and cockroaches) is predominant in patients in our and other areas.
Covariation of sensitisation (CS) to these allergens could be due to
cross-reactivity or parallel sensitisation.
Methods: Skin prick tests were performed to common and second-line home
aeroallergens, shrimp and tropomyosin in 253 paediatric patients seen in
our Unit due to chronic respiratory symptoms. CS among the main
allergens was analysed by means of Cohen's kappa coefficient of
concordance (kappa).
Results: House dust mites (HDM) were the main allergens involved in
sensitisation, followed by furry animals, pollens, storage mites (SM),
moulds and cockroaches. CS was very good between D. pteronyssinus and D.
farinae (kappa = 0.81), and good between Dermatophagoides and
Euroglyphus (kappa = 0.71), and decreased markedly to poor (kappa <
0.20) between HDM and SM or cockroaches. CS among SM and cockroaches was
moderate to fair (kappa = 0.21-0.44). CS was good between shrimp and
tropomyosin (kappa = 0.62), but null between shrimp-tropomyosin and HDM
(kappa = 0.01-0.02), and poor to fair between shrimp-tropomyosin and SM
or cockroaches (kappa=0.06-0.34). CS between cat and dog was moderate
(kappa = 0.50).
Conclusions: We have shown the usefulness of kappa in exploring CS in a
population. In our area, with high sensitisation to HDM and other home
allergens, CS is limited for most pairs of allergens, pointing to a
lower incidence of cross-reactivity than could be expected, especially
between HDM and SM or other invertebrates. (C) 2016 SEICAP. Published by
Elsevier Espana, S.L.U. All rights reserved.
Filiaciones:
:
Hosp Gen Univ Alicante, Pediat Allergy & Resp Unit, Alicante, Spain
:
Hosp Gen Univ Alicante, Pediat Allergy & Resp Unit, Alicante, Spain
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