Cultural adaptation and validation of a peninsular Spanish version of the MSTCQ(C) Multiple sclerosis; (Multiple Sclerosis Treatment Concerns Questionnaire)
Por:
Munteis Olivas, E, Navarro Mascarell, G, Meca Lallana, J, Maestre Martinez, A, Perez Sempere, A, Gracia Gil, J and Pato Pato, A
Publicada:
1 ene 2017
Resumen:
Introduction: Although subcutaneous treatments for multiple sclerosis
(MS) have been shown to be effective, adverse reactions and pain may
adversely affect treatment satisfaction and adherence. This study
presents an adapted and validated Spanish version of the Multiple
Sclerosis Treatment Concerns Questionnaire (c) (MSTCQ), which evaluates
satisfaction with the injection device (ID) across 4 domains: injection
system (A), side effects (B) (flu-like symptoms, reactions, and
satisfaction), experience with treatment (C) and benefits (D). Methods:
Two study phases: 1) Cultural adaptation process with input from experts
(n = 6) and patients (n = 30). 2) Validation obtained by means of an
observational, cross-sectional, multi centre study evaluating 143 adult
MS patients using an ID. Tools employed: MSTCQ, Patient Reported Indices
for Multiple Sclerosis (PRIMUS<((C))under bar>), and Treatment
Satisfaction Questionnaire for Medication (TSQM (c)). Psychometric
properties: Feasibility (percentage of valid cases and floor/ceiling
effects); Reliability (Cronbach alpha) and test-retest correlation (n
=41, intractass correlation coefficient, ICC); and construct validity
(factor analysis of domains A and B) and convergent validity (Spearman
rank-order correlation for MSTCQ (c) vs TSQM (c)). Results: Mean age
(SD) was 41.94 (10.47) years, 63% of the group were women, and 88.11%
presented relapsing-remitting MS. Mean (SD) EDSS score was 2.68 (1.82)
points. MSTCQ (c) completion was high (0%-2.80% missing data). Internal
consistency was high at alpha = 0.89 for the total score (A+ B) and
alpha = 0.76, 0.89, and 0.92 for domains A, B, and C, respectively. The
version demonstrated excellent test-retest reliability for the total
(ICC = 0.98) and for domains A, B, and C: ICC =0.82, 0.97, and 0.89,
respectively. Factor analysis corroborated the internal structure of the
original questionnaire. The association between total and domain scores
on both the MSTCQ (c) and the TSQM (c) was moderately strong (Rho =
0.42-0.74) and significant (P <.05 and P<.01). Conclusion: The Spanish
version of MSTCQ demonstrates appropriate psychometric properties. 2014
Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L.U.
Filiaciones:
Munteis Olivas, E:
Hosp del Mar, Barcelona, Spain
Navarro Mascarell, G:
Hosp Virgen De La Macarena, Seville, Spain
Meca Lallana, J:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Esclerosis Milltiple, Murcia, Spain
UCAM Univ Catal San Antonio Murcia, Catedra Neuroinmunol Clin & Esclerosis Multiple, Murcia, Spain
Maestre Martinez, A:
Hosp Jaen, Jaen, Spain
:
Hosp Gen Alicante, Alicante, Spain
Gracia Gil, J:
Hosp Albacete, Albacete, Spain
Pato Pato, A:
Hosp Povisa, Vigo, Pontevedra, Spain
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