Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain.
Por:
Signes-Pastor AJ, Vioque J, Navarrete-Muñoz EM, Carey M, García de la Hera M, Sunyer J, Casas M, Riaño-Galán I, Tardón A, Llop S, Amorós R, Karagas MR and Meharg AA
Publicada:
1 nov 2017
Ahead of Print:
31 jul 2017
Resumen:
Inorganic arsenic (i-As) has been related to wide-ranging health effects in children, leading to lifelong concerns. Proportionally, dietary i-As exposure dominates in regions with low arsenic drinking water. This study aims to investigate the relation between rice and seafood consumption and urinary arsenic species during childhood and to assess the proportion of urinary i-As metabolites. Urinary arsenic species concentration in 400 4-year-old children living in four geographical areas of Spain, in addition to repeated measures from 100 children at 7 years of age are included in this study. Rice and seafood products intake was collected from children's parents using a validated food frequency questionnaire (FFQ). At 4 years of age, children's urine i-As and monomethylarsonic acid (MMA) concentrations increased with rice product consumption (p-value = 0.010 and 0.018, respectively), and urinary arsenobetaine (AsB) with seafood consumption (p = 0.002). Four-year-old children had a higher consumption of both rice and seafood per body weight and a higher urinary %MMA (p-value = 0.001) and lower % dimethylarsinic acid (DMA) (p-value = 0.017). This study suggests increased dietary i-As exposure related to rice product consumption among children living in Spain, and the younger ones may be especially vulnerable to the health impacts of this exposure also considering that they might have a lower i-As methylation capacity than older children. In contrast, seafood consumption did not appear to influence the presence of potentially toxic arsenic species in this population of children.
Filiaciones:
Signes-Pastor AJ:
Institute for Global Food Security, Queen's University Belfast, David Keir Building, Malone Road, Belfast BT9 5BN, Northern Ireland, UK.
:
University Miguel Hernández, Faculty of Medicine and Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Ctra. Valencia s/n, 03550 Sant Joan d´Alacant, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain
:
University Miguel Hernández, Faculty of Medicine and Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Ctra. Valencia s/n, 03550 Sant Joan d´Alacant, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain
Carey M:
Institute for Global Food Security, Queen's University Belfast, David Keir Building, Malone Road, Belfast BT9 5BN, Northern Ireland, UK
:
University Miguel Hernández, Faculty of Medicine and Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Ctra. Valencia s/n, 03550 Sant Joan d´Alacant, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain
Sunyer J:
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Universitat Pompeu Fabra, Barcelona, Spain
Casas M:
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Universitat Pompeu Fabra, Barcelona, Spain
Riaño-Galán I:
Pediatric Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
Tardón A:
IUOPA-Universidad de Oviedo, Spain
Llop S:
Epidemiology and Environmental Health Joint Research Unit, Universitat Jaume I-Universitat de València, València, Spain
Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO, Valencia, Spain
Amorós R:
Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO, Valencia, Spain
Karagas MR:
Department of Epidemiology, Geisel School of Medicine, Dartmouth College, 1 Medical Center Dr, 7927 Rubin Bldg, Lebanon NH03766, USA
Meharg AA:
Institute for Global Food Security, Queen's University Belfast, David Keir Building, Malone Road, Belfast BT9 5BN, Northern Ireland, UK
Green Accepted, Green Published
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