Maternal selenium status and neuropsychological development in Spanish preschool children


Por: Amorós R, Murcia M, González L, Rebagliato M, Iniguez, C, Lopez-Espinosa MJ, Vioque J, Broberg K, Ballester F and Llop S

Publicada: 1 oct 2018
Resumen:
Background: The relationship between maternal selenium (Se) status and child neurodevelopment has been scarcely assessed. In a previous study we observed an inverse U-shaped association between maternal Se concentrations and infant neurodevelopment at 12 months of age. In this study, this non-linear association was explored at preschool age. The effect modification by breastfeeding, child's sex and cord blood mercury was also evaluated. Methods: Study subjects were 490 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2012). Child neuropsychological development was assessed at around 5 years of age by the McCarthy Scales of Children's Abilities (MSCA). Sociodemographic and dietary characteristics were collected by questionnaire at the first and third trimester of gestation and at 5 years of age. Se was measured in serum samples by ICP-MS at the end of the first trimester of pregnancy (mean +/- standard deviation (SD) = 12.4 +/- 0.6 weeks of gestation). Results: The mean +/- SD of maternal serum Se concentrations was 79.9 +/- 8.1 mu g/L. In multivariate analysis, no linear association was found between Se concentrations and the nine MSCA scales. Generalized additive models indicated inverted U-shaped relationships between Se concentrations and the verbal and global memory scales. When assessing the influence of effect modifiers, breastfeeding played a role: the association between Se and neuropsychological development was inverted U-shaped for the quantitative, general cognitive, working memory, fine motor, global motor and executive function scales only for non-breastfed children. Conclusion: Low and high maternal Se concentrations seem to be harmful for child neuropsychological development, however further studies should explore this non-linear relationship.

Filiaciones:
Amorós R:
 FISABIO, Fdn Promot Hlth & Biomed Res Valencian Reg, Av Catalunya 21, Valencia 46020, Spain

 Univ Edinburgh, Sch Math, Peter Guthrie Tait Rd, Edinburgh EH9 3FD, Midlothian, Scotland

 Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO, Av. Catalunya 21, 46020 Valencia, Spain

 School of Mathematics, University of Edinburgh, Peter Guthrie Tait Road, EH9 3FD Edinburgh, United Kingdom

Murcia M:
 Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Av Monforte Lemos 3-5,Pabellon 11, Madrid 28029, Spain

 Univ Valencia, Univ Jaume 1, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Av Catalunya 21, Valencia 46020, Spain

 Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain

 Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain

González L:
 Univ Valencia, Univ Jaume 1, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Av Catalunya 21, Valencia 46020, Spain

 Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain

Rebagliato M:
 Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Av Monforte Lemos 3-5,Pabellon 11, Madrid 28029, Spain

 Univ Valencia, Univ Jaume 1, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Av Catalunya 21, Valencia 46020, Spain

 Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain

 Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain

Iniguez, C:
 Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Av Monforte Lemos 3-5,Pabellon 11, Madrid 28029, Spain

 Univ Valencia, Univ Jaume 1, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Av Catalunya 21, Valencia 46020, Spain

 Univ Valencia, Dept Stat & Operat Res, Carver Dr Moliner 50, Buijassot 46100, Spain

Lopez-Espinosa MJ:
 Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Av Monforte Lemos 3-5,Pabellon 11, Madrid 28029, Spain

 Univ Valencia, Univ Jaume 1, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Av Catalunya 21, Valencia 46020, Spain

 Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain

 Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain

:
 Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Av Monforte Lemos 3-5,Pabellon 11, Madrid 28029, Spain

 Univ Miguel Hemeindez, Dept Publ Hlth, Av Alicante KM 87, Sant Joan dAlacant 03550, Spain

 Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain

 Department of Public Health, Universitat Miguel Hernández, Av. de Alicante KM 87, 03550 Sant Joan d´Alacant, Spain

Broberg K:
 Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, S-17177 Stockholm, Sweden

 Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 17177 Stockholm, Sweden

Ballester F:
 Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Av Monforte Lemos 3-5,Pabellon 11, Madrid 28029, Spain

 Univ Valencia, Univ Jaume 1, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Av Catalunya 21, Valencia 46020, Spain

 Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain

 Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain

Llop S:
 Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Av Monforte Lemos 3-5,Pabellon 11, Madrid 28029, Spain

 Univ Valencia, Univ Jaume 1, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Av Catalunya 21, Valencia 46020, Spain

 Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain

 Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain

Department of Statistics and Operational Research, Universitat de València, Carrer del Dr. Moliner, 50, 46100 Burjassot, Spain
ISSN: 00139351





ENVIRONMENTAL RESEARCH
Editorial
ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 166 Número:
Páginas: 215-222
WOS Id: 000445318200024
ID de PubMed: 29890426

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