Hyperlipoproteinaemia(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project
Por:
Garcia-Gomez, C, Martin-Martinez, M, Fernandez-Carballido, C, Castaneda, S, Gonzalez-Juanatey, C, Sanchez-Alonso, F, Gonzalez-Fernandez, M, Sanmarti, R, Garcia-Vadillo, J, Fernandez-Gutierrez, B, Garcia-Arias, M, Manero, F, Senabre, J, Rueda-Cid, A, Ros-Exposito, S, Pina-Salvador, J, Erra-Duran, A, Moller-Parera, I, Llorca, J, Gonzalez-Gay, M, Gonzalez de Rabago, E, Blanco Morales, E, Fernandez Lopez, J, Oreiro Villar, N, Atanes Sandoval, A, Blanco Garcia, F, Alegre De Miquel, C, Gonzalez Fernandez, M, Huguet Codina, R, Yoldi, B, Ramentol, M, Avila, G, Marsal Barril, S, Steiner, M, Munoz, S, Gamero, F, Garcia Toron, J, Moreno Gil, M, Mas, A, Espino, P, Ros, I, Ibanez, M, Murillo, C, Piqueras, J, Sanmarti, R, Berman, H, Cabrera, S, Ruiz, V, Fontsere Paton, O, Fernandez Gutierrez, B, Abasolo, L, Fabregas, M, Romera Baures, M, Nolla, J, Gonzalez-Alvaro, I, Tomero Muriel, E, Garcia de Vicuna, R, Fernandez Nebro, A, Belmonte Lopez, M, Urena, I, Irigoyen, M, Coret Cagigal, V, Lopez Gonzalez, R, Pielfort Garrido, D, Sampedro Alvarez, J, Garcia Aparicio, A, Belmonte Gomez, R, Granados Bautista, P, Hernandez Sanz, A, Sanchez Gonzalez, C, Bachiller, J, Zea, A, Manero, F, Jimenez Zorzo, F, Gimenez Ubeda, E, Marzo Gracia, J, Beltran Audera, C, Medrano, M, Pecondon, A, Erausquin, C, Ojeda, S, Carlos Quevedo, J, Francisco, F, Rodriguez Lozano, C, Babio Herraez, J, Lopez Longo, F, Gerona, D, Gonzalez Fernandez, C, Carreno, L, Monteagudo, I, del Pino, J, Sanchez Gonzalez, M, Corrales, A, Enriqueta Peiro, M, Senabre, J, Rosas, J, Rotes, I, Moreno, E, Erra, A, Grado, D, Calvo, J, Rueda, A, Moller, I, Rodriguez, I, Barbadillo, C, Raya, E, Morales, P, Nieto, A, Jimenez, I, Magro, C, Ruibal Escribano, A, Ros Exposito, S, Sanchez Nievas, G, Judez Navarro, E, Sianes Fernandez, M, Garcia Morales, M, Labiano Bastero, I, Consuegra, G, Palmou, N, Martinez Pardo, S, Pujol, M, Riera Alonso, E, Salvador, G, Gonzalez Alvarez, B, Cantabrana, A, Bustabad, S, Delgado, E, Munoz, A, Rodriguez Montero, S, Maria Jimenez, L, Rivera Redondo, J, Gonzalez Hernandez, T, Gonzalez Polo, F, Menor Almagro, R, Moreno, J, Giner Serret, E, Lannuzzelli Barroso, C, Cebrian Mendez, L, Teresa Navio, M, Fernandez Carballido, C, Pagan, E, Mesa del Castillo, P, Naredo, E, Cruz, A, Turrion, A, Mateo, I, Sanchez, J, Galindo, M, Garcia Gonzalez, J, Collantes, E, Ruiz, D, Font, P, Bonilla, G, Lopez Meseguer, A, Moreno, M, Moreno Martinez, M, Beteta Fernandez, M, Linares, L, Morcillo, M, Gonzalez Gomez, M, Aramburu, J, Rivera, N, Fernandez Berrizbeitia, O, Garcia Vivar, M, Riera, M, Maria Leon, Y, Maymo, J, Amirall, M, Iniesta Escolano, S, Sanchez Serrano, S, Lis Bona, M, Fiter, J, Fernandez Melon, J, Espadaler, L, Maiz, O, Belzunegui, J, Banegil, I, Diaz, C, Valls, R, Castellvi, I, Bonet, M, Moreno Ruzafa, E, Calvo Alen, J, Perez Sandoval, T, Revuelta Evrard, E, Godo, J, Fernandez Espartero, C, Navarro Blasco, F, Antonio Gonzalez, J, Miranda-Filloy, J and CARMA Project Collaborative Grp
Publicada:
1 sep 2019
Resumen:
Objective
Cardiovascular (CV) disease is one of the main causes of morbi-mortality
in spondyloarthritis (SpA), partially explained by traditional CV risk
factors. Information on lipoprotein(a) [Lp(a)], a non-conventional
risk factor, in SpA is scarce. In this study we assessed the prevalence
of hyperlipoproteinaemia(a) in SpA patients and analysed the possible
related factors.
Methods
A baseline analysis was made of ankylosing spondylitis (AS) and
psoriatic arthritis (PsA) patients and controls included in the CARMA
project (CARdiovascular in RheuMAtology), a 10-year prospective study
evaluating the risk of CV events in chronic inflammatory rheumatic
diseases. A multivariate logistic regression model was performed using
hyperlipoproteinaemia( a) (Lp(a) >50 mg/dl) as a dependent variable and
adjusting for confounding factors.
Results
19.2% (95% CI: 16.80-22.05) of the SpA patients [20.7% (95% CI:
16.91-24.82) of those with AS and 17.7% (95% CI: 14.15-21.75) of those
with PsA] and 16.7% (95% CI: 13.23-20.86) of the controls had
hyperlipoproteinaemia(a) (p=0.326). Adjusting for age and sex, SpA
patients were more likely to have hyperlipoproteinaemia(a) than controls
(OR: 1.43, 95% CI: 1.00-2.04; p=0.05), especially those with AS (OR:
1.81, 95% CI: 1.18-2.77; p=0.007). In the adjusted model,
apolipoprotein B in all patients, non-steroidal anti-inflammatory drugs
in AS, and female sex in PsA, were associated with
hyperlipoproteinaemia(a). No disease-specific factors associated with
hyperlipoproteinaemia(a) were identified.
Conclusion
SpA patients show a moderately increased risk of
hyperlipoproteinaemia(a) compared to controls, especially those with AS.
Lp(a) determination may be of interest to improve the CV risk assessment
in SpA patients.
Filiaciones:
Garcia-Gomez, C:
Consorci Sanitari Terrassa, Div Rheumatol, Barcelona, Spain
Martin-Martinez, M:
Res Unit Spanish Soc Rheumatol, Madrid, Spain
:
Hosp U Elda, Div Rheumatol, Alicante, Spain
Gonzalez-Juanatey, C:
Hosp U Lucus Augusti, Div Cardiol, Lugo, Spain
Sanchez-Alonso, F:
Res Unit Spanish Soc Rheumatol, Madrid, Spain
Gonzalez-Fernandez, M:
Hosp Univ Dexeus, Div Rheumatol, Barcelona, Spain
Sanmarti, R:
Hosp Clin Barcelona, Div Rheumatol, Barcelona, Spain
aimon , Hosp Clin Barcelona, Barcelona, Spain
Fernandez-Gutierrez, B:
Hosp Clin San Carlos, Div Rheumatol, Madrid, Spain
Garcia-Arias, M:
Ponferrada, Div Rheumatol, Leon, Spain
Manero, F:
Hosp Miguel Servet, Div Rheumatol, Zaragoza, Spain
Senabre, J:
Hosp Marina Baixa, Div Rheumatol, La Vila Joiosa, Alicante, Spain
Rueda-Cid, A:
Hosp Gen U Valencia, Div Rheumatol, Barcelona, Spain
Ros-Exposito, S:
Hosp Viladecans, Div Rheumatol, Barcelona, Spain
Pina-Salvador, J:
Hosp Barbastro, Div Rheumatol, Huesca, Spain
Erra-Duran, A:
Hosp Sant Rafael, Div Rheumatol, Barcelona, Spain
Moller-Parera, I:
Inst Poal, Div Rheumatol, Barcelona, Spain
Llorca, J:
Univ Cantabria, IDIVAL, Santander, Spain
CIBER Epidemiol Salud Publ CIBERESP, Santander, Spain
Gonzalez-Gay, M:
Univ Cantabria, Hosp Univ Marques Valdecilla,IDIVAL, Genet & Atherosclerosis Res Grp, System Inflammatory Dis Rheumatol Div, Santander, Spain
Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Cardiovasc Pathophysiol & Genom Res Unit, Johannesburg, South Africa
Gonzalez de Rabago, E:
Complejo Hosp A Coruna, Xubias De Arriba, A Coruna, Spain
Blanco Morales, E:
Complejo Hosp A Coruna, Xubias De Arriba, A Coruna, Spain
Fernandez Lopez, J:
Complejo Hosp A Coruna, Xubias De Arriba, A Coruna, Spain
Oreiro Villar, N:
Complejo Hosp A Coruna, Xubias De Arriba, A Coruna, Spain
Atanes Sandoval, A:
Complejo Hosp A Coruna, Xubias De Arriba, A Coruna, Spain
Blanco Garcia, F:
Complejo Hosp A Coruna, Xubias De Arriba, A Coruna, Spain
Alegre De Miquel, C:
Inst Dexeus, Barcelona, Spain
Gonzalez Fernandez, M:
Inst Dexeus, Barcelona, Spain
Huguet Codina, R:
Inst Dexeus, Barcelona, Spain
Yoldi, B:
Inst Dexeus, Barcelona, Spain
Ramentol, M:
Inst Dexeus, Barcelona, Spain
Avila, G:
Hosp Univ Vall dHebron, Barcelona, Spain
Marsal Barril, S:
Hosp Univ Vall dHebron, Barcelona, Spain
Steiner, M:
Hosp Infanta Sofia, Madrid, Spain
Munoz, S:
Hosp Infanta Sofia, Madrid, Spain
Gamero, F:
Hosp Infanta Sofia, Madrid, Spain
Hosp S Pedro de Alcantara, Caceres, Spain
Garcia Toron, J:
Hosp Infanta Sofia, Madrid, Spain
Hosp S Pedro de Alcantara, Caceres, Spain
Moreno Gil, M:
Hosp Infanta Sofia, Madrid, Spain
Hosp S Pedro de Alcantara, Caceres, Spain
Mas, A:
Hosp Son Llatzer, Palma De Mallorca, Spain
Espino, P:
Hosp Son Llatzer, Palma De Mallorca, Spain
Ros, I:
Hosp Son Llatzer, Palma De Mallorca, Spain
Ibanez, M:
Hosp Son Llatzer, Palma De Mallorca, Spain
Murillo, C:
Hosp Son Llatzer, Palma De Mallorca, Spain
Piqueras, J:
Hosp Univ Guadalajara, Barcelona, Spain
Sanmarti, R:
aimon , Hosp Clin Barcelona, Barcelona, Spain
Berman, H:
aimon , Hosp Clin Barcelona, Barcelona, Spain
Cabrera, S:
aimon , Hosp Clin Barcelona, Barcelona, Spain
Ruiz, V:
aimon , Hosp Clin Barcelona, Barcelona, Spain
Fontsere Paton, O:
Hosp Clin Univ San Carlos, Madrid, Spain
Fernandez Gutierrez, B:
Hosp Clin Univ San Carlos, Madrid, Spain
Abasolo, L:
Hosp Clin Univ San Carlos, Madrid, Spain
Fabregas, M:
Hosp Barbastro, Huesca, Spain
Romera Baures, M:
Hosp Univ Bellvitge, Barcelona, Spain
Nolla, J:
Hosp Univ Bellvitge, Barcelona, Spain
Gonzalez-Alvaro, I:
Hosp Univ De La Princesa, Madrid, Spain
Tomero Muriel, E:
Hosp Univ De La Princesa, Madrid, Spain
Garcia de Vicuna, R:
Hosp Univ De La Princesa, Madrid, Spain
Fernandez Nebro, A:
Hosp Reg Univ Carlos Haya, Malaga, Spain
Belmonte Lopez, M:
Hosp Reg Univ Carlos Haya, Malaga, Spain
Urena, I:
Hosp Reg Univ Carlos Haya, Malaga, Spain
Irigoyen, M:
Hosp Reg Univ Carlos Haya, Malaga, Spain
Coret Cagigal, V:
Hosp Reg Univ Carlos Haya, Malaga, Spain
Lopez Gonzalez, R:
Hosp Gen Virgen Concha, Zamora, Spain
Pielfort Garrido, D:
Hosp Virgen de la Salud, Toledo, Spain
Sampedro Alvarez, J:
Hosp Virgen de la Salud, Toledo, Spain
Garcia Aparicio, A:
Hosp Virgen de la Salud, Toledo, Spain
Belmonte Gomez, R:
Hosp Virgen de la Salud, Toledo, Spain
Granados Bautista, P:
Hosp Virgen de la Salud, Toledo, Spain
Hernandez Sanz, A:
Hosp Virgen de la Salud, Toledo, Spain
Sanchez Gonzalez, C:
Hosp Sureste, Madrid, Spain
Bachiller, J:
Hosp Ramon & Cajal, Madrid, Spain
Zea, A:
Hosp Ramon & Cajal, Madrid, Spain
Manero, F:
Hosp Univ Miguel Servet, Zaragoza, Spain
Jimenez Zorzo, F:
Hosp Univ Miguel Servet, Zaragoza, Spain
Gimenez Ubeda, E:
Hosp Univ Miguel Servet, Zaragoza, Spain
Marzo Gracia, J:
Hosp Univ Miguel Servet, Zaragoza, Spain
Beltran Audera, C:
Hosp Univ Miguel Servet, Zaragoza, Spain
Medrano, M:
Hosp Univ Miguel Servet, Zaragoza, Spain
Pecondon, A:
Hosp Univ Miguel Servet, Zaragoza, Spain
Erausquin, C:
Hosp Dr Negrin, Las Palmas Gran Canaria, Spain
Ojeda, S:
Hosp Dr Negrin, Las Palmas Gran Canaria, Spain
Carlos Quevedo, J:
Hosp Dr Negrin, Las Palmas Gran Canaria, Spain
Francisco, F:
Hosp Dr Negrin, Las Palmas Gran Canaria, Spain
Rodriguez Lozano, C:
Hosp Dr Negrin, Las Palmas Gran Canaria, Spain
Babio Herraez, J:
Hosp Cabuenes, Gijon, Spain
Lopez Longo, F:
Hosp Gregorio Maranon, Madrid, Spain
Gerona, D:
Hosp Gregorio Maranon, Madrid, Spain
Gonzalez Fernandez, C:
Hosp Gregorio Maranon, Madrid, Spain
Carreno, L:
Hosp Gregorio Maranon, Madrid, Spain
Monteagudo, I:
Hosp Gregorio Maranon, Madrid, Spain
del Pino, J:
Hosp Univ Salamanca, Salamanca, Spain
Sanchez Gonzalez, M:
Hosp Univ Salamanca, Salamanca, Spain
Corrales, A:
Hosp Univ Marques de Valdecilla, Santander, Spain
Enriqueta Peiro, M:
Hosp Univ Marques de Valdecilla, Santander, Spain
Senabre, J:
Hosp Marina Baixa, Alicante, Spain
Rosas, J:
Hosp Marina Baixa, Alicante, Spain
Moreno, E:
Hosp San Rafael, Barcelona, Spain
Erra, A:
Hosp San Rafael, Barcelona, Spain
Grado, D:
Hosp San Rafael, Barcelona, Spain
Calvo, J:
Hosp Gen Univ, Valencia, Spain
Rueda, A:
Hosp Gen Univ, Valencia, Spain
Moller, I:
Inst Poal, Barcelona, Spain
Rodriguez, I:
Inst Poal, Barcelona, Spain
Barbadillo, C:
Hosp Univ Puerta Hierro, Madrid, Spain
Raya, E:
Hosp Clin Univ San Cecilio, Granada, Spain
Morales, P:
Hosp Clin Univ San Cecilio, Granada, Spain
Nieto, A:
Hosp Clin Univ San Cecilio, Granada, Spain
Jimenez, I:
Hosp Clin Univ San Cecilio, Granada, Spain
Magro, C:
Hosp Clin Univ San Cecilio, Granada, Spain
Ruibal Escribano, A:
Hosp Santiago Apostol, Vitoria, Spain
Ros Exposito, S:
Hosp Viladecans, Barcelona, Spain
Sanchez Nievas, G:
Hosp Gen Albacete, Albacete, Spain
Judez Navarro, E:
Hosp Gen Albacete, Albacete, Spain
Sianes Fernandez, M:
Hosp Gen Albacete, Albacete, Spain
Garcia Morales, M:
Hosp Gen Albacete, Albacete, Spain
Labiano Bastero, I:
Hosp Gen Albacete, Albacete, Spain
Consuegra, G:
Hosp Gen Albacete, Albacete, Spain
Palmou, N:
Hosp Gen Albacete, Albacete, Spain
Martinez Pardo, S:
Hosp Mutua Terrassa, Terrassa, Spain
Pujol, M:
Hosp Mutua Terrassa, Terrassa, Spain
Riera Alonso, E:
Hosp Mutua Terrassa, Terrassa, Spain
Salvador, G:
Hosp Mutua Terrassa, Terrassa, Spain
Gonzalez Alvarez, B:
Hosp Ntra Sra Candelaria, Santa Cruz De Tenerife, Spain
Cantabrana, A:
Hosp Ntra Sra Candelaria, Santa Cruz De Tenerife, Spain
Bustabad, S:
Hosp Univ Canarias, Tenerife, Spain
Delgado, E:
Hosp Univ Canarias, Tenerife, Spain
Munoz, A:
Hosp Univ Valme, Seville, Spain
Rodriguez Montero, S:
Hosp Univ Valme, Seville, Spain
Maria Jimenez, L:
Hosp Univ Valme, Seville, Spain
Rivera Redondo, J:
Inst Prov Rehabil, Madrid, Spain
Gonzalez Hernandez, T:
Inst Prov Rehabil, Madrid, Spain
Gonzalez Polo, F:
Hosp Cantoblanco, Madrid, Spain
Menor Almagro, R:
Hosp Jerez de la Frontera, Cadiz, Spain
Moreno, J:
Hosp Obispo Polanco, Teruel, Spain
Giner Serret, E:
Hosp Obispo Polanco, Teruel, Spain
Lannuzzelli Barroso, C:
Hosp Obispo Polanco, Teruel, Spain
Cebrian Mendez, L:
Hosp Infanta Leonor, Madrid, Spain
Teresa Navio, M:
Hosp Infanta Leonor, Madrid, Spain
Fernandez Carballido, C:
Hosp Gen Elda, Alicante, Spain
Pagan, E:
Hosp Los Arcos, Murcia, Spain
Mesa del Castillo, P:
Hosp Los Arcos, Murcia, Spain
Naredo, E:
Hosp Severo Ochoa, Madrid, Spain
Cruz, A:
Hosp Severo Ochoa, Madrid, Spain
Turrion, A:
Hosp Principe Asturias, Madrid, Spain
Mateo, I:
Hosp Univ 12 Octubre, Madrid, Spain
Sanchez, J:
Hosp Univ 12 Octubre, Madrid, Spain
Galindo, M:
Hosp Univ 12 Octubre, Madrid, Spain
Garcia Gonzalez, J:
Hosp Univ 12 Octubre, Madrid, Spain
Collantes, E:
Hosp Univ Reina Sofia, Cordoba, Spain
Ruiz, D:
Hosp Univ Reina Sofia, Cordoba, Spain
Font, P:
Hosp Univ Reina Sofia, Cordoba, Spain
Bonilla, G:
Hosp Univ La Paz, Madrid, Spain
Lopez Meseguer, A:
Hosp Gutierrez Ortega, Ciudad Real, Spain
Moreno, M:
Hosp Virgen Arrixaca, Murcia, Spain
Moreno Martinez, M:
Hosp Virgen Arrixaca, Murcia, Spain
Beteta Fernandez, M:
Hosp Virgen Arrixaca, Murcia, Spain
Linares, L:
Hosp Virgen Arrixaca, Murcia, Spain
Gonzalez Gomez, M:
Hosp Escorial, Madrid, Spain
Aramburu, J:
Hosp Basurto, Bilbao, Spain
Rivera, N:
Hosp Basurto, Bilbao, Spain
Fernandez Berrizbeitia, O:
Hosp Basurto, Bilbao, Spain
Garcia Vivar, M:
Hosp Basurto, Bilbao, Spain
Riera, M:
Hosp Dos de Maig, Barcelona, Spain
Maria Leon, Y:
Hosp Dos de Maig, Barcelona, Spain
Maymo, J:
Hosp Mar, Barcelona, Spain
Amirall, M:
Hosp Mar, Barcelona, Spain
Iniesta Escolano, S:
Hosp Mar, Barcelona, Spain
Sanchez Serrano, S:
Hosp Mar, Barcelona, Spain
Lis Bona, M:
Hosp Mar, Barcelona, Spain
Fiter, J:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Fernandez Melon, J:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Espadaler, L:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Maiz, O:
Hosp Donostia, Donostia San Sebastian, Spain
Belzunegui, J:
Hosp Donostia, Donostia San Sebastian, Spain
Banegil, I:
Hosp Donostia, Donostia San Sebastian, Spain
Diaz, C:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Valls, R:
Hosp Palamos, Girona, Spain
Castellvi, I:
Hosp Comarcal LAlt Penedes, Barcelona, Spain
Bonet, M:
Hosp Comarcal LAlt Penedes, Barcelona, Spain
Moreno Ruzafa, E:
Hosp Comarcal LAlt Penedes, Barcelona, Spain
Calvo Alen, J:
Hosp Sierrallana, Torrelavega, Spain
Perez Sandoval, T:
Complejo Asistencial Leon, Leon, Spain
Revuelta Evrard, E:
Gen Hosp Ciudad Real, Ciudad Real, Spain
Godo, J:
Hosp Gen Mostoles, Madrid, Spain
Fernandez Espartero, C:
Hosp Gen Mostoles, Madrid, Spain
Navarro Blasco, F:
Hosp Gen Univ Elche, Alicante, Spain
Antonio Gonzalez, J:
Hosp Gen Univ Elche, Alicante, Spain
Miranda-Filloy, J:
Hosp Xeral Calde, Lugo, Spain
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