EarLy Elimination of Fatty Acids iN hypertriglyceridemia-induced acuTe pancreatitis (ELEFANT trial): Protocol of an open-label, multicenter, adaptive randomized clinical trial.
Por:
Zádori N, Gede N, Antal J, Szentesi A, Alizadeh H, Vincze Á, Izbéki F, Papp M, Czakó L, Varga M, de-Madaria E, Petersen OH, Singh VP, Mayerle J, Faluhelyi N, Miseta A, Reiber I and Hegyi P
Publicada:
1 abr 2020
Ahead of Print:
30 dic 2019
Resumen:
Acute pancreatitis (AP) is a life-threatening inflammatory disease, with no specific pharmacological treatment. However, concerning some etiologies, early specific intervention (such as ERCP in biliary AP) has proven to be remarkably beneficial. Hypertriglyceridemia (HTG) induces severe pancreatic damage by several direct (cellular damage) and indirect (deterioration of microcirculation) mechanisms. Published data suggest that early removal of triglycerides (TGs) and toxic free fatty acids (FFAs) may be advantageous; however, high-quality evidence is still missing in the literature.
Filiaciones:
Zádori N:
Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary
Gede N:
Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary
Antal J:
Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary
Szentesi A:
Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary
Hungarian Academy of Sciences-University of Szeged, Translational Multidisciplinary Research Group, Szeged, Hungary
Alizadeh H:
Division of Hematology, First Department of Internal Medicine, University of Pécs Medical School, Pécs, Hungary
Vincze Á:
Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary
Division of Gastroenterology, First Department of Internal Medicine, University of Pécs Medical School, Pécs, Hungary
Izbéki F:
Division of Gastroenterology, Fejér County Saint George Teaching Hospital of the University of Pécs, Székesfehérvár, Hungary
Papp M:
Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Czakó L:
First Department of Internal Medicine, University of Szeged, Szeged, Hungary
Varga M:
Dr. Réthy Pál Hospital, Békéscsaba, Hungary
:
Department of Gastroenterology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain
Petersen OH:
School of Biosciences, Cardiff University, Wales, UK
Singh VP:
Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA
Mayerle J:
Medizinische Klinik und Poliklinik II, Klinikum der Universität München, München, Germany
Faluhelyi N:
Department of Radiology, University of Pécs, Pécs, Hungary
Miseta A:
Department of Laboratory Medicine, University of Pécs, Pécs, Hungary
Reiber I:
Division of Gastroenterology, Fejér County Saint George Teaching Hospital of the University of Pécs, Székesfehérvár, Hungary
Hegyi P:
Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary
Hungarian Academy of Sciences-University of Szeged, Translational Multidisciplinary Research Group, Szeged, Hungary
Green Published
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