Real life outcomes of patients aged =75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry.
Por:
Salamero O, Martínez-Cuadrón D, Sobas M, Benavente C, Vives S, De la Serna J, Pérez-Encinas M, Escoda L, Gil C, Brunet S, Ramos F, Esteve J, Amigo M, Krsnik I, Manso F, Arias J, González-Campos J, Serrano J, Oleksiuk J, Barrios M, García-Boyero R, Novo A, Sanz MA, Montesinos P and PETHEMA and PALG Groups
Publicada:
1 nov 2019
Resumen:
Acute promyelocytic leukemia is infrequent among patients aged =75 years old, a population that is rarely eligible for clinical protocols. This study aims to analyze the treatment strategies and clinical outcomes of very old APL patients reported to the international PETHEMA registry. Between 1997 and 2017, among 2501 APL cases registered 120 were =75 years old. Treatment approaches were: AIDA regimen, 79 patients; ATRA alone, 23; 16, supportive care (SC) and 2, other strategies. Patients treated with AIDA were younger, had better ECOG and lower leukocytes. Complete remission (CR) was achieved in 65% of AIDA-group vs. 45% in the ATRA-group, being infections followed by bleeding the most frequent causes of induction death. Patients in CR after AIDA showed 3-year DFS of 73%. Our real-life series of very old APL patients provides a reference basis for future treatment strategies aiming to improve clinical outcomes in this challenging population.
Filiaciones:
Salamero O:
UAB-Medicine Department, Hospital Universitario Vall d'Hebron, VHIO, Barcelona, Spain
Martínez-Cuadrón D:
Hospital Universitari i Politecnic La Fe, valencia, Spain
CIBERONC, Instituto Carlos III, Madrid, Spain
Sobas M:
Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland
Benavente C:
Hospital Clínico San Carlos, Madrid, Spain
Vives S:
ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras Research Institute, Badalona, Spain
De la Serna J:
Hospital 12 de Octubre, Madrid, Spain
Pérez-Encinas M:
Hospital Clínico Universitario, Santiago de Compostela, Spain
Escoda L:
Hospital Joan XXIII, Tarragona, Spain
:
Hospital General de Alicante, Alicante, Spain
Brunet S:
Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Ramos F:
Hospital Universitario de León, Léon, Spain
Esteve J:
Hospital Clinic, Barcelona, Spain
Amigo M:
Hospital Morales Meseguer, Murcia, Spain
Krsnik I:
Hospital Puerta del Hierro, Madrid, Spain
Manso F:
Hospital General de Albacete, Albacete, Spain
Arias J:
Hospital Universitario Lucus Augusti, Lugo, Spain
González-Campos J:
Hospital Universitario Virgen del Rocío, Sevilla, Spain
Serrano J:
Hospital Reina Sofía, Córdoba, Spain
Oleksiuk J:
Medical University of Bialystok, Bialystok, Poland
Barrios M:
Hospital Regional Universitario Carlos Haya, Málaga, Spain
García-Boyero R:
Hospital General de Castellón, Castellón, Spain
Novo A:
Hospital Universitari Son Espases, Palma, Spain
Sanz MA:
Hospital Universitari i Politecnic La Fe, valencia, Spain
CIBERONC, Instituto Carlos III, Madrid, Spain
Montesinos P:
Hospital Universitari i Politecnic La Fe, valencia, Spain
CIBERONC, Instituto Carlos III, Madrid, Spain
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