Association of cannabinoid receptor genes (CNR1 and CNR2) polymorphisms and panic disorder
Por:
Peiró AM, Garcia-Gutierrez, M, Planelles, B, Femenia, T, Mingote, C, Jimenez-Trevino, L, Martinez-Barrondo, S, Garcia-Portilla, M, Saiz, P, Bobes, J and Manzanares, J
Publicada:
3 may 2020
Ahead of Print:
1 feb 2020
Resumen:
Background and objectives: Panic disorder (PD) is an anxiety disorder characterized by recurrent and unexpected panic attacks along with sudden onset of apprehension, fear or terror. The endocannabinoid system (ECS) has a role in stress recovery, regulating anxiety. The aim of this study was to analyze potential genetic alterations in key ECS targets in patients suffering from panic disorders. Design and methods: We analyzed single nucleotide polymorphisms (SNPs) of the cannabinoid receptors (CNR1; CNR2) and the endocannabinoid hydrolytic enzyme fatty acid amide hydrolase (FAAH) genes in 164 Spanish PD patients and 320 matched controls. Results: No significant differences were observed in the SNPs of the CNR2 and FAAH genes tested. However, when analyzing genotype-by-sex interaction at A592G (rs2501431) and C315T (rs2501432) in the CNR2 gene, the presence of the G-allele in males was associated with a protective haplotype. Genotyping analysis revealed that variants in CNR1 confer vulnerability to PD, with a significantly increased risk associated with the G-allele (rs12720071) and C-allele (rs806368). This finding was consistent when analyzing genotype-by-sex interaction, where females presented a greater PD risk. Conclusions: Polymorphisms at the CNR1 gene may be a risk factor for PD contributing to sex-specific dysfunction in females.
Filiaciones:
:
ISABIAL, Clin Pharmacol Unit & Neuropharmacol Pain & Funct, Dept Hlth Alicante, Gen Hosp, Alicante, Spain
Garcia-Gutierrez, M:
Miguel Hernandez Univ, Neurosci Inst, Alacant, Spain
MICINN, Hlth Inst Carlos III, Cooperat Networking Hlth Res RETICS Saddict Disor, Madrid, Spain
FEDER, Madrid, Spain
:
Hosp Gen Hosp, Res Unit, Alicante, Spain
Femenia, T:
Miguel Hernandez Univ, Neurosci Inst, Alacant, Spain
Mingote, C:
Univ Hosp 12 Octubre, Madrid, Spain
Jimenez-Trevino, L:
Univ Oviedo, Fac Med, Dept Psychiat, Asturias, Spain
Biomed Res Ctr Mental Hlth Network CIBERSAM, Asturias, Spain
INEUROPA, Univ Inst Neurosci Asturias, Asturias, Spain
SESPA, Hlth Serv Asturias, Asturias, Spain
Martinez-Barrondo, S:
Univ Oviedo, Fac Med, Dept Psychiat, Asturias, Spain
Biomed Res Ctr Mental Hlth Network CIBERSAM, Asturias, Spain
INEUROPA, Univ Inst Neurosci Asturias, Asturias, Spain
SESPA, Hlth Serv Asturias, Asturias, Spain
Garcia-Portilla, M:
Univ Oviedo, Fac Med, Dept Psychiat, Asturias, Spain
Biomed Res Ctr Mental Hlth Network CIBERSAM, Asturias, Spain
INEUROPA, Univ Inst Neurosci Asturias, Asturias, Spain
SESPA, Hlth Serv Asturias, Asturias, Spain
Saiz, P:
Univ Oviedo, Fac Med, Dept Psychiat, Asturias, Spain
Biomed Res Ctr Mental Hlth Network CIBERSAM, Asturias, Spain
INEUROPA, Univ Inst Neurosci Asturias, Asturias, Spain
SESPA, Hlth Serv Asturias, Asturias, Spain
Bobes, J:
Univ Oviedo, Fac Med, Dept Psychiat, Asturias, Spain
Biomed Res Ctr Mental Hlth Network CIBERSAM, Asturias, Spain
INEUROPA, Univ Inst Neurosci Asturias, Asturias, Spain
SESPA, Hlth Serv Asturias, Asturias, Spain
Manzanares, J:
Miguel Hernandez Univ, Neurosci Inst, Alacant, Spain
MICINN, Hlth Inst Carlos III, Cooperat Networking Hlth Res RETICS Saddict Disor, Madrid, Spain
FEDER, Madrid, Spain
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