Antimicrobial management of Tropheryma whipplei endocarditis: the Spanish Collaboration on Endocarditis (GAMES) experience
Por:
Garcia-Alvarez, L, Sanz, M, Marin, M, Farinas, M, Montejo, M, Goikoetxea, J, Garcia, R, de Alarcon, A, Almela, M, Fernandez-Hidalgo, N, Socas, M, Goenaga, M, Navas, E, Vicioso, L, Oteo, J, Adan, I, Sanchez, F, Noureddine, M, Rosas, G, Lima, J, Aramendi, J, Bereciartua, E, Boado, M, Lazaro, M, Goiti, J, Hernandez, J, Iruretagoyena, J, Zuazabal, J, Lopez-Soria, L, Perez, P, Rodriguez, R, Voces, R, Lopez, M, Georgieva, R, Solero, M, Bailon, I, Morales, J, Cuende, A, Echeverria, T, Fuerte, A, Gaminde, E, Idigoras, P, Iribarren, J, Yarza, A, Urkola, X, Reviejo, C, Carrasco, R, Climent, V, Llamas, P, Merino, E, Plazas, J, Reus, S, Alvarez, N, Bravo-Ferrer, J, Castelo, L, Cuenca, J, Llinares, P, Rey, E, Mayo, M, Sanchez, E, Regueiro, D, Martinez, F, Alonso, M, Castro, B, Marrero, D, Duran, M, Gomez, M, La Calzada, J, Nassar, I, Ciezar, A, Iglesias, J, Alvarez, V, Costas, C, de la Hera, J, Suarez, J, Fraile, L, Arguero, V, Menendez, J, Bajo, P, Morales, C, Torrico, A, Palomo, C, Martinez, B, Esteban, A, Asensio, M, Ambrosioni, J, Armero, Y, Azqueta, M, Brunet, M, Cartana, R, Falces, C, Fita, G, Fuster, D, de la Maria, C, Gatell, J, Perez, J, Manzardo, C, Marco, F, Miro, J, Moreno, A, Ninot, S, Quintana, E, Pare, C, Pereda, D, Pericas, J, Pomar, J, Ramirez, J, Rovira, I, Sitges, M, Soy, D, Tellez, A, Vidal, B, Vila, J, Bermejo, J, Bouza, E, Cuerpo, G, de Egea, V, Eworo, A, Cruz, A, Leoni, M, del Vecchio, M, Ramallo, V, Hernandez, M, Martinez-Selles, M, Menarguez, M, Munoz, P, Rincon, C, Rodriguez-Abella, H, Rodriguez-Creixems, M, Pinilla, B, Pinto, A, Valerio, M, Moreno, E, Antorrena, I, Loeches, B, Moreno, M, Ramirez, U, Baston, V, Romero, M, Saldana, A, Castillo, C, Arnaiz, A, Berrazueta, J, Bellisco, S, Belaustegui, M, Duran, R, Farinas-Alvarez, C, Mazarrasa, C, Izquierdo, R, Rico, C, Diez, J, Duran, R, Pajaron, M, Parra, J, Teira, R, Zarauza, J, Pavia, P, Gonzalez, J, Orden, B, Ramos, A, Gonzalez, E, Centella, T, Hermida, J, Moya, J, Martin-Davila, P, Oliva, E, del Rio, A, Ruiz, S, Tenorio, C, de Castro, A, de Cueto, M, Gallego, P, Acebal, J, Bano, J, Garcia, E, Haro, J, Lepe, J, Lopez, F, Luque, R, Alonso, L, Azcarate, P, Gutierrez, J, Blanco, J, de Benito, N, Gurgui, M, Pacho, C, Pericas, R, Pons, G, Alvarez, M, Fernandez, A, Martinez, A, Prieto, A, Regueiro, B, Tijeira, E, Vega, M, Blasco, A, Mollar, J, Arana, J, Uriarte, O, Lopez, A, de Zarate, Z, Matos, J, Nacle, M, Sanchez-Porto, A, Vallejo, L, Leal, J, Vazquez, E, Torres, A, Blazquez, A, Valenzuela, G, Alonso, A, Aramburu, J, Calvo, F, Rodriguez, A, Tarabini-Castellani, P, Galvez, E, Bellido, C, Pau, J, Sepulveda, M, Sierra, P, Iqbal-Mirza, S, Alcolea, E, Serrano, P, Roca, J, Escobar, E, Monje, A, Cabrera, V, Garcia, D, Luna, C, Morcillo, J, Seco, M and Spanish Collaboration Endocarditis
Publicada:
1 jun 2019
Resumen:
Objectives: Tropheryma whipplei has been detected in 3.5% of the blood culture-negative cases of endocarditis in Spain. Experience in the management of T. whipplei endocarditis is limited. Here we report the long-term outcome of the treatment of previously reported patients who were diagnosed with infective endocarditis (IE) caused by T. whipplei from the Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en Espana (GAMES) and discuss potential options for antimicrobial therapy for IE caused by T. whipplei.
Patients and methods: Seventeen patients with T. whipplei endocarditis were recruited between 2008 and 2014 in 25 Spanish hospitals. Patients were classified according to the therapeutic regimen: ceftriaxone and trimethoprim/sulfamethoxazole, doxycycline + hydroxychloroquine and other treatment options.
Results: Follow-up data were obtained from 14 patients. The median follow-up was 46.5months. All patients completed the antibiotic treatment prescribed, with a median duration of 13months. Six patients were treated with ceftriaxone and trimethoprim/sulfamethoxazole (median duration 13months), four with doxycycline + hydroxychloroquine (median duration 13.8months) and four with other treatment options (median duration 22.3months). The follow-up after the end of the treatments was between 5 and 84months (median 24months).
Conclusions: All treatment lines were effective and well tolerated. Therapeutic failures were not detected during the treatment. None of the patients died or experienced a relapse during the follow-up. Only six patients received antibiotic treatment in accordance with guidelines. These data suggest that shorter antimicrobial treatments could be effective.
Filiaciones:
Garcia-Alvarez, L:
Hosp Univ San Pedro, Ctr Invest Biomed La Rioja CIBIR, Dept Enfermedades Infecciosas, Logrono, Spain
Hosp San Pedro, Logrono, Spain
Sanz, M:
Hosp Univ San Pedro, Ctr Invest Biomed La Rioja CIBIR, Dept Enfermedades Infecciosas, Logrono, Spain
Hosp San Pedro, Logrono, Spain
Marin, M:
Hosp Gen Univ Gregorio Maranon, Serv Microbiol Clin & Enfermedades Infecciosas, Madrid, Spain
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Farinas, M:
Univ Cantabria, Hosp Univ Marques de Valdecilla, Serv Enfermedades Infecciosas, Santander, Spain
Hosp Univ Marques de Valdecilla, Santander, Spain
Montejo, M:
Hosp Univ Cruces, Unidad Enfermedades Infecciosas, Bilbao, Spain
Univ Basque Country, Bilbao, Spain
Hosp Univ Cruces, Bilbao, Spain
Goikoetxea, J:
Hosp Univ Cruces, Unidad Enfermedades Infecciosas, Bilbao, Spain
Univ Basque Country, Bilbao, Spain
Hosp Univ Cruces, Bilbao, Spain
Garcia, R:
Hosp Univ Cent Asturias, Serv Med Intens, Oviedo, Spain
Univ Oviedo, Oviedo, Spain
Hosp Univ Cent Asturias, Oviedo, Spain
de Alarcon, A:
Hosp Univ Virgen del Rocio, Unidad Gest Clin Enfermedades Infecciosas Microbi, Seville, Spain
Hosp Univ Virgen del Rocio, Seville, Spain
Almela, M:
Hosp Clin Barcelona, Serv Microbiol & Parasitol, Barcelona, Spain
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Fernandez-Hidalgo, N:
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Serv Malalties Infeccioses, Barcelona, Spain
Socas, M:
Hosp Univ Canarias, Serv Enfermedades Infecciosas, Tenerife, Spain
Goenaga, M:
Hosp Donostia, OSI Donostialdea, Serv Enfermedades Infecciosas, San Sebastian, Gipuzkoa, Spain
Hosp Univ Donostia Policlin Gipuzkoa, San Sebastian, Spain
Navas, E:
Hosp Univ Ramon & Cajal, Serv Enfermedades Infecciosas, Madrid, Spain
Hosp Univ Ramon & Cajal, Madrid, Spain
Vicioso, L:
Hosp Clin Univ Virgen de la Victoria, Serv Anat Patol, Malaga, Spain
Oteo, J:
Hosp Univ San Pedro, Ctr Invest Biomed La Rioja CIBIR, Dept Enfermedades Infecciosas, Logrono, Spain
Hosp San Pedro, Logrono, Spain
Adan, I:
Hosp Costa del Sol, Marbella, Spain
Sanchez, F:
Hosp Costa del Sol, Marbella, Spain
Noureddine, M:
Hosp Costa del Sol, Marbella, Spain
Rosas, G:
Hosp Costa del Sol, Marbella, Spain
Lima, J:
Hosp Costa del Sol, Marbella, Spain
Aramendi, J:
Hosp Univ Cruces, Bilbao, Spain
Bereciartua, E:
Hosp Univ Cruces, Bilbao, Spain
Boado, M:
Hosp Univ Cruces, Bilbao, Spain
Lazaro, M:
Hosp Univ Cruces, Bilbao, Spain
Goiti, J:
Hosp Univ Cruces, Bilbao, Spain
Hernandez, J:
Hosp Univ Cruces, Bilbao, Spain
Iruretagoyena, J:
Hosp Univ Cruces, Bilbao, Spain
Zuazabal, J:
Hosp Univ Cruces, Bilbao, Spain
Lopez-Soria, L:
Hosp Univ Cruces, Bilbao, Spain
Perez, P:
Hosp Univ Cruces, Bilbao, Spain
Rodriguez, R:
Hosp Univ Cruces, Bilbao, Spain
Voces, R:
Hosp Univ Cruces, Bilbao, Spain
Lopez, M:
Hosp Univ Virgen de la Victoria, Malaga, Spain
Georgieva, R:
Hosp Univ Virgen de la Victoria, Malaga, Spain
Solero, M:
Hosp Univ Virgen de la Victoria, Malaga, Spain
Bailon, I:
Hosp Univ Virgen de la Victoria, Malaga, Spain
Morales, J:
Hosp Univ Virgen de la Victoria, Malaga, Spain
Cuende, A:
Hosp Univ Donostia Policlin Gipuzkoa, San Sebastian, Spain
Echeverria, T:
Hosp Univ Donostia Policlin Gipuzkoa, San Sebastian, Spain
Fuerte, A:
Hosp Univ Donostia Policlin Gipuzkoa, San Sebastian, Spain
Gaminde, E:
Hosp Univ Donostia Policlin Gipuzkoa, San Sebastian, Spain
Idigoras, P:
Hosp Univ Donostia Policlin Gipuzkoa, San Sebastian, Spain
Iribarren, J:
Hosp Univ Donostia Policlin Gipuzkoa, San Sebastian, Spain
Yarza, A:
Hosp Univ Donostia Policlin Gipuzkoa, San Sebastian, Spain
Urkola, X:
Hosp Univ Donostia Policlin Gipuzkoa, San Sebastian, Spain
Reviejo, C:
Hosp Univ Donostia Policlin Gipuzkoa, San Sebastian, Spain
Carrasco, R:
Hosp Gen Univ Alicante, Alicante, Spain
:
Hosp Gen Univ Alicante, Alicante, Spain
:
Hosp Gen Univ Alicante, Alicante, Spain
:
Hosp Gen Univ Alicante, Alicante, Spain
:
Hosp Gen Univ Alicante, Alicante, Spain
:
Hosp Gen Univ Alicante, Alicante, Spain
Alvarez, N:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Bravo-Ferrer, J:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Castelo, L:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Cuenca, J:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Llinares, P:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Rey, E:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Mayo, M:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Sanchez, E:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Regueiro, D:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Martinez, F:
Complejo Hosp Especialidades Juan Ramon Jimenez, Huelva, Spain
Alonso, M:
Hosp Univ Canarias, Canarias, Spain
Castro, B:
Hosp Univ Canarias, Canarias, Spain
Marrero, D:
Hosp Univ Canarias, Canarias, Spain
Duran, M:
Hosp Univ Canarias, Canarias, Spain
Gomez, M:
Hosp Univ Canarias, Canarias, Spain
La Calzada, J:
Hosp Univ Canarias, Canarias, Spain
Nassar, I:
Hosp Univ Canarias, Canarias, Spain
Ciezar, A:
Hosp Reg Univ Malaga, Malaga, Spain
Iglesias, J:
Hosp Reg Univ Malaga, Malaga, Spain
Alvarez, V:
Hosp Univ Cent Asturias, Oviedo, Spain
Costas, C:
Hosp Univ Cent Asturias, Oviedo, Spain
de la Hera, J:
Hosp Univ Cent Asturias, Oviedo, Spain
Suarez, J:
Hosp Univ Cent Asturias, Oviedo, Spain
Fraile, L:
Hosp Univ Cent Asturias, Oviedo, Spain
Arguero, V:
Hosp Univ Cent Asturias, Oviedo, Spain
Menendez, J:
Hosp Univ Cent Asturias, Oviedo, Spain
Bajo, P:
Hosp Univ Cent Asturias, Oviedo, Spain
Morales, C:
Hosp Univ Cent Asturias, Oviedo, Spain
Torrico, A:
Hosp Univ Cent Asturias, Oviedo, Spain
Palomo, C:
Hosp Univ Cent Asturias, Oviedo, Spain
Martinez, B:
Hosp Univ Cent Asturias, Oviedo, Spain
Esteban, A:
Hosp Univ Cent Asturias, Oviedo, Spain
Asensio, M:
Hosp Univ Cent Asturias, Oviedo, Spain
Ambrosioni, J:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Armero, Y:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Azqueta, M:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Brunet, M:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Cartana, R:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Falces, C:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Fita, G:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Fuster, D:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
de la Maria, C:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Gatell, J:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Perez, J:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Manzardo, C:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Marco, F:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Miro, J:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Moreno, A:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Ninot, S:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Quintana, E:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Pare, C:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Pereda, D:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Pericas, J:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Pomar, J:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Ramirez, J:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Rovira, I:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Sitges, M:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Soy, D:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Tellez, A:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Vidal, B:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Vila, J:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Bermejo, J:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Bouza, E:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Cuerpo, G:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
de Egea, V:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Eworo, A:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Cruz, A:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Leoni, M:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
del Vecchio, M:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Ramallo, V:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Hernandez, M:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Martinez-Selles, M:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Menarguez, M:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Munoz, P:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Rincon, C:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Rodriguez-Abella, H:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Rodriguez-Creixems, M:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Pinilla, B:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Pinto, A:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Valerio, M:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Moreno, E:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Antorrena, I:
Hosp Univ La Paz, Madrid, Spain
Loeches, B:
Hosp Univ La Paz, Madrid, Spain
Moreno, M:
Hosp Univ La Paz, Madrid, Spain
Ramirez, U:
Hosp Univ La Paz, Madrid, Spain
Baston, V:
Hosp Univ La Paz, Madrid, Spain
Romero, M:
Hosp Univ La Paz, Madrid, Spain
Saldana, A:
Hosp Univ La Paz, Madrid, Spain
Castillo, C:
Hosp Univ Marques de Valdecilla, Santander, Spain
Arnaiz, A:
Hosp Univ Marques de Valdecilla, Santander, Spain
Berrazueta, J:
Hosp Univ Marques de Valdecilla, Santander, Spain
Bellisco, S:
Hosp Univ Marques de Valdecilla, Santander, Spain
Belaustegui, M:
Hosp Univ Marques de Valdecilla, Santander, Spain
Duran, R:
Hosp Univ Marques de Valdecilla, Santander, Spain
Farinas-Alvarez, C:
Hosp Univ Marques de Valdecilla, Santander, Spain
Mazarrasa, C:
Hosp Univ Marques de Valdecilla, Santander, Spain
Izquierdo, R:
Hosp Univ Marques de Valdecilla, Santander, Spain
Rico, C:
Hosp Univ Marques de Valdecilla, Santander, Spain
Diez, J:
Hosp Univ Marques de Valdecilla, Santander, Spain
Duran, R:
Hosp Univ Marques de Valdecilla, Santander, Spain
Pajaron, M:
Hosp Univ Marques de Valdecilla, Santander, Spain
Parra, J:
Hosp Univ Marques de Valdecilla, Santander, Spain
Teira, R:
Hosp Univ Marques de Valdecilla, Santander, Spain
Zarauza, J:
Hosp Univ Marques de Valdecilla, Santander, Spain
Pavia, P:
Hosp Univ Puerta de Hierro, Madrid, Spain
Gonzalez, J:
Hosp Univ Puerta de Hierro, Madrid, Spain
Orden, B:
Hosp Univ Puerta de Hierro, Madrid, Spain
Ramos, A:
Hosp Univ Puerta de Hierro, Madrid, Spain
Gonzalez, E:
Hosp Univ Puerta de Hierro, Madrid, Spain
Centella, T:
Hosp Univ Ramon & Cajal, Madrid, Spain
Hermida, J:
Hosp Univ Ramon & Cajal, Madrid, Spain
Moya, J:
Hosp Univ Ramon & Cajal, Madrid, Spain
Martin-Davila, P:
Hosp Univ Ramon & Cajal, Madrid, Spain
Oliva, E:
Hosp Univ Ramon & Cajal, Madrid, Spain
del Rio, A:
Hosp Univ Ramon & Cajal, Madrid, Spain
Ruiz, S:
Hosp Univ Ramon & Cajal, Madrid, Spain
Tenorio, C:
Hosp Univ Virgen de las Nieves, Granada, Spain
de Castro, A:
Hosp Univ Virgen Macarena, Seville, Spain
de Cueto, M:
Hosp Univ Virgen Macarena, Seville, Spain
Gallego, P:
Hosp Univ Virgen Macarena, Seville, Spain
Acebal, J:
Hosp Univ Virgen Macarena, Seville, Spain
Bano, J:
Hosp Univ Virgen Macarena, Seville, Spain
Garcia, E:
Hosp Univ Virgen del Rocio, Seville, Spain
Haro, J:
Hosp Univ Virgen del Rocio, Seville, Spain
Lepe, J:
Hosp Univ Virgen del Rocio, Seville, Spain
Lopez, F:
Hosp Univ Virgen del Rocio, Seville, Spain
Luque, R:
Hosp Univ Virgen del Rocio, Seville, Spain
Alonso, L:
Hosp San Pedro, Logrono, Spain
Azcarate, P:
Hosp San Pedro, Logrono, Spain
Gutierrez, J:
Hosp San Pedro, Logrono, Spain
Blanco, J:
Hosp San Pedro, Logrono, Spain
de Benito, N:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Gurgui, M:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Pacho, C:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Pericas, R:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Pons, G:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Alvarez, M:
Complejo Hosp Univ Santiago de Compostela, La Coruna, Spain
Fernandez, A:
Complejo Hosp Univ Santiago de Compostela, La Coruna, Spain
Martinez, A:
Complejo Hosp Univ Santiago de Compostela, La Coruna, Spain
Prieto, A:
Hosp Santiago Apostol, Vitoria, Spain
Regueiro, B:
Complejo Hosp Univ Santiago de Compostela, La Coruna, Spain
Tijeira, E:
Complejo Hosp Univ Santiago de Compostela, La Coruna, Spain
Vega, M:
Complejo Hosp Univ Santiago de Compostela, La Coruna, Spain
Blasco, A:
Hosp Santiago Apostol, Vitoria, Spain
Mollar, J:
Hosp Santiago Apostol, Vitoria, Spain
Arana, J:
Hosp Santiago Apostol, Vitoria, Spain
Uriarte, O:
Hosp Santiago Apostol, Vitoria, Spain
Lopez, A:
Hosp Santiago Apostol, Vitoria, Spain
de Zarate, Z:
Hosp Santiago Apostol, Vitoria, Spain
Matos, J:
Hosp Santiago Apostol, Vitoria, Spain
Nacle, M:
Hosp SAS Linea Concepc, Cadiz, Spain
Sanchez-Porto, A:
Hosp SAS Linea Concepc, Cadiz, Spain
Vallejo, L:
Hosp SAS Linea Concepc, Cadiz, Spain
Leal, J:
Hosp Clin Univ Virgen de la Arrixaca, Murcia, Spain
Vazquez, E:
Hosp Clin Univ Virgen de la Arrixaca, Murcia, Spain
Torres, A:
Hosp Clin Univ Virgen de la Arrixaca, Murcia, Spain
Blazquez, A:
Hosp Clin Univ Virgen de la Arrixaca, Murcia, Spain
Valenzuela, G:
Hosp Clin Univ Virgen de la Arrixaca, Murcia, Spain
Alonso, A:
Hosp Txagorritxu, Vitoria, Spain
Aramburu, J:
Hosp Txagorritxu, Vitoria, Spain
Calvo, F:
Hosp Txagorritxu, Vitoria, Spain
Rodriguez, A:
Hosp Txagorritxu, Vitoria, Spain
Tarabini-Castellani, P:
Hosp Txagorritxu, Vitoria, Spain
Galvez, E:
Hosp Virgen Salud, Toledo, Spain
Bellido, C:
Hosp Virgen Salud, Toledo, Spain
Pau, J:
Hosp Virgen Salud, Toledo, Spain
Sepulveda, M:
Hosp Virgen Salud, Toledo, Spain
Sierra, P:
Hosp Virgen Salud, Toledo, Spain
Iqbal-Mirza, S:
Hosp Virgen Salud, Toledo, Spain
Alcolea, E:
Hosp Rafael Mendez, Lorca Murcia, Spain
Serrano, P:
Hosp Rafael Mendez, Lorca Murcia, Spain
Roca, J:
Hosp Rafael Mendez, Lorca Murcia, Spain
Escobar, E:
Hosp Univ San Cecilio, Granada, Spain
Monje, A:
Hosp Univ San Cecilio, Granada, Spain
Cabrera, V:
Hosp Univ San Cecilio, Granada, Spain
Garcia, D:
Hosp Univ San Cecilio, Granada, Spain
Luna, C:
Hosp Son Llatzer, Palma De Mallorca, Spain
Morcillo, J:
Hosp Son Llatzer, Palma De Mallorca, Spain
Seco, M:
Hosp Son Llatzer, Palma De Mallorca, Spain
Spanish Collaboration Endocarditis:
Spanish Collaboration Endocarditis, Spain, España.
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