Quality of life and disease severity in dermatitis patients with fragrance allergy-A cross-sectional European questionnaire study
Por:
Bennike, N, Heisterberg, M, White, I, Mahler, V, Silvestre-Salvador, J, Gimenez-Arnau, A and Johansen, J
Publicada:
1 ago 2019
Resumen:
Background: Fragrance contact allergy is common, but few studies on quality of life (QoL) in affected patients exist. Recently, the disease-specific Fragrance Quality of Life Index (FQLI) was developed.
Objectives: To characterize QoL in European dermatitis patients with fragrance contact allergy at the time of diagnosis.
Methods: This was a cross-sectional study, in which 2011 Danish, British, Spanish and German adult consecutive dermatitis patients were invited to complete a questionnaire on self-reported disease severity, the Dermatology Life Quality Index (DLQI), and the FQLI immediately prior to being patch tested.
Results: One thousand seven hundred and fifty-eight patients responded, and 259 (14.7%; country range 11.7%-18.5%) were fragrance-positive. Among these, the total (SD) DLQI score was 6.2 (5.6) and the total (SD) FQLI score was 60 (25), with both estimates being comparable to those in fragrance-negative patients. Adjusting the total FQLI score for age, sex and self-rated disease severity showed a higher (ie, worse) score in fragrance-positive patients (3.6-point increase; 95% confidence interval: 0.30-6.8 points; P = 0.03). Specifically, contact allergy to oxidized linalool was associated with greater impairment in QoL
Conclusions: QoL in patients with fragrance contact allergy is impaired at a level comparable to that in other patch tested dermatitis patients, at the time of diagnosis, across several European countries.
Filiaciones:
Bennike, N:
Copenhagen Univ Hosp Herlev Gentofte, Dept Dermatol & Allergy, Natl Allergy Res Ctr, Hellerup, Denmark
Heisterberg, M:
Copenhagen Univ Hosp Herlev Gentofte, Dept Dermatol & Allergy, Natl Allergy Res Ctr, Hellerup, Denmark
White, I:
Guys & St Thomas Hosp, St Johns Inst Dermatol, London, England
Mahler, V:
Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Dermatol, Erlangen, Germany
Paul Ehrlich Inst, Langen, Germany
:
Hosp Gen Alicante, Dept Dermatol, Alicante, Spain
Gimenez-Arnau, A:
Univ Autonoma Barcelona, Hosp del Mar, Dept Dermatol, IMIM, Barcelona, Spain
Johansen, J:
Copenhagen Univ Hosp Herlev Gentofte, Dept Dermatol & Allergy, Natl Allergy Res Ctr, Hellerup, Denmark
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