EUS-FNA cytological material from pancreatic lesions: the expression of cathepsins and its predictive value of malignancy.
Por:
Roger M, Martínez J, Peiró G, Aparicio JR, Ruiz F, Compañy L and Casellas JA
Publicada:
1 jul 2018
Resumen:
AIMS: To assess the expression of cathepsins in pancreatic samples obtained by endoscopic ultrasonography and fine needle aspiration (EUS-FNA) and to investigate their relationship with the staging of the pancreatic ductal adenocarcinoma (PDAC). METHODS: We prospectively included patients with solid pancreatic masses, in which EUS-FNA were performed. Cathepsins B, L, S and H expression was determined in FNA samples. RESULTS: Seventeen FNA were performed. All cytological material was from PDAC. Expression of cathepsins was predominantly low (B 65%, L 23%, S 76%, and H 41%). We found no correlation between the expression levels and the extension of the neoplasm. CONCLUSION: Expression of cathepsins in the cytological material of PDAC is diverse but still poor to be useful in the pre-operative diagnosis. There is no correlation between the expression levels of cathepsins and the extension of the PDAC.
Filiaciones:
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Unidad de Endoscopia Digestiva, Hospital General Universitario de Alicante, España
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Unidad de Endoscopia Digestiva, Hospital General Universitario de Alicante
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Servicio de Anatomía Patológica, Hospital General Universitario de Alicante
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Unidad de Endoscopia Digestiva, Hospital General Universitario de Alicante
:
Unidad de Endoscopia Digestiva, Hospital General Universitario de Alicante, España
:
Unidad de Endoscopia Digestiva, Hospital General Universitario de Alicante, España
:
Unidad de Endoscopia Digestiva, Hospital General Universitario de Alicante, España
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