The Modulation of the Startle Reflex as Predictor of Alcohol Use Disorders in a Sample of Heavy Drinkers: A 4-Year Follow-Up Study.
Por:
Jurado-Barba R, Duque A, López-Trabada JR, Martínez-Gras I, García-Gutiérrez MS, Navarrete F, López-Muñoz F, Jiménez-Arriero MÁ, Ávila C, Manzanares J and Rubio G
Publicada:
1 jun 2017
Ahead of Print:
11 may 2017
Resumen:
BACKGROUND: Previous studies demonstrated that patients with alcohol use disorders (AUDs) show altered startle reflex responses to alcohol-related stimuli. However, there is little information about the role of these altered responses in the development of AUDs. This study examined the startle reflex response to different visual stimuli and the role of these patterns in the development of AUDs in a 4-year follow-up. METHODS: Two hundred and thirty-nine (nondependent) heavy-drinking participants were selected. In the baseline period, the startle reflex responses to alcohol-related, aversive, appetitive, and neutral pictures were assessed. Startle reflex responses to these pictures were used as predictive variables. Status drinking (alcohol dependence and nondependence) assessed at 4-year follow-up was used as outcome measure. RESULTS: At the 4-year follow-up assessment, 46% of participants fulfilled DSM-IV alcohol abuse or dependence criteria. Alcohol dependence status was predicted by an attenuated startle reflex response to alcohol-related and aversive pictures. CONCLUSIONS: This study revealed that an attenuated modulation of startle reflex response to alcohol-related and aversive stimuli could be used as a clinical marker to predict the development of AUDs in participants with previous alcohol consumption.
Filiaciones:
Jurado-Barba R:
Research Institute Hospital 12 de Octubre (i + 12), Madrid, Spain
Camilo José Cela University , Madrid, Spain
Duque A:
Pontifical University of Salamanca , Salamanca, Spain
Complutense University of Madrid , Madrid, Spain
López-Trabada JR:
University Hospital 12 de Octubre , Madrid, Spain
Martínez-Gras I:
University Hospital 12 de Octubre , Madrid, Spain
Biomedical Research Center Network for Mental Health (CIBERSAM) , Madrid, Spain
:
Instituto de Neurociencias , Miguel Hernández University, San Juan de Alicante, Alicante, Spain
Red Temática de Investigación Cooperativa en Salud (RETICS) , Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain
Navarrete F:
Instituto de Neurociencias , Miguel Hernández University, San Juan de Alicante, Alicante, Spain
Red Temática de Investigación Cooperativa en Salud (RETICS) , Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain
López-Muñoz F:
Camilo José Cela University , Madrid, Spain
Jiménez-Arriero MÁ:
Research Institute Hospital 12 de Octubre (i + 12), Madrid, Spain
University Hospital 12 de Octubre , Madrid, Spain
Biomedical Research Center Network for Mental Health (CIBERSAM) , Madrid, Spain
Ávila C:
Jaume I University , Castellón, Spain
:
Instituto de Neurociencias , Miguel Hernández University, San Juan de Alicante, Alicante, Spain
Red Temática de Investigación Cooperativa en Salud (RETICS) , Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain
Rubio G:
Complutense University of Madrid , Madrid, Spain
University Hospital 12 de Octubre , Madrid, Spain
Red Temática de Investigación Cooperativa en Salud (RETICS) , Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain
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