Factors associated with moderate neonatal hyperthyrotropinemia.
Por:
Cortés-Castell E, Juste M, Palazón-Bru A, Goicoechea M, Gil-Guillén VF and Rizo-Baeza MM
Publicada:
1 ene 2019
Ahead of Print:
18 jul 2019
Resumen:
BACKGROUND: Maternal iodine deficiency is related to high neonatal thyroid-stimulating hormone (TSH) values, with the threshold of 5 mIU/L recommended as an indicator of iodine nutrition status. The objective of this study was to analyse possible risk factors for increased TSH that could distort its validity as a marker of iodine status. The clinical relevance of this research question is that if the factors associated with iodine deficiency are known, iodine supplementation can be introduced in risk groups, both during pregnancy and in newborns. METHODS: A case-control study was carried out in a sample of 46,622 newborns in 2002-2015 in Spain. Of these, 45,326 had a neonatal TSH value =5 mIU/L. The main variable was having TSH =5 mIU/L and the secondary variables were: sex, gestational age, day of sample extraction and maternal origin. Associated factors were analysed through a logistic regression model, calculating the odds ratio (OR). RESULTS: The factors associated with this outcome were: male sex (OR = 1.34, 95% CI: 1.20-1.50, p<0.001), originating from an Asian/Oceanic country (OR = 0.80, 95% CI: 0.54-1.20, p = 0.536) or Europe (OR = 0.80, 95% CI: 0.66-0.96, p = 0.285) (including Spain, OR = 1) [p<0.001 for America (OR = 0.54, 95% CI: 0.44-0.68) and p = 0.025 for Africa (OR = 0.78, 95% CI: 0.62-0.97)] and fewer days from birth to sampling (OR = 0.80, 95% CI: 0.77-0.82, p<0.001). CONCLUSIONS: The risk of high neonatal TSH without congenital hypothyroidism is higher in males, decreases with a greater number of days from birth to extraction, and is dependent on maternal ethnicity but not on gestational age.
Filiaciones:
:
Department of Pharmacology, Pediatrics and Organic Chemistry, Miguel Hernández University, San Juan de Alicante, Alicante, Spain
Juste M:
Department of Pharmacology, Pediatrics and Organic Chemistry, Miguel Hernández University, San Juan de Alicante, Alicante, Spain
:
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Alicante, Spain
Goicoechea M:
Center for Advanced Research in Public Health, Generalitat Valenciana, Valencia, Valencia, Spain
:
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Alicante, Spain
:
Department of Nursing, University of Alicante, San Vicente del Raspeig, Alicante, Spain
Open Access
|