Real-world experience of ocrelizumab in multiple sclerosis in a Spanish population
Por:
Fernandez-Diaz, E, Perez-Vicente, J, Villaverde-Gonzalez, R, Berenguer-Ruiz, L, Merlicco, A, Martinez-Navarro, M, Gil, J, Romero-Sanchez, C, Alfaro-Saez, A, Diaz, I, Gimenez-Martinez, J, Mendez-Miralles, M, Millan-Pascual, J, Jimenez-Pancho, J, Mola, S and Sempere, A
Publicada:
1 feb 2021
Ahead of Print:
1 dic 2020
Resumen:
Objective: Pivotal trial have shown that patients with multiple sclerosis (MS) receiving ocrelizumab had better outcomes. However, data on ocrelizumab in clinical practice are limited. The aim of this study was to evaluate the preliminary safety profile and effectiveness of ocrelizumab treatment for multiple sclerosis (MS) in a real-world clinical setting. Methods: We conducted a retrospective study including consecutive patients from nine public hospitals in south-eastern Spain who received ocrelizumab after it was approved. Results: A total of 228 MS patients were included (144 with relapsing- remitting MS [RRMS], 25 secondary progressive MS [SPMS], and 59 primary progressive MS [PPMS]). Median follow-up period was 12 months (range, 1-32). No evidence of disease activity (NEDA) status at year 1 was achieved in 91.2% of the relapsing MS (RMS) population, while disability progression was detected in 37.5% of the PPMS patients (median follow-up period, 19 months). The most common adverse events reported were infusion-related reactions and infections, with the most common infections being urinary tract infections followed by upper respiratory infections and COVID-19. Interpretation: The preliminary results in our real-world setting show that ocrelizumab presented excellent results in suppressing disease activity with a favorable and consistent safety profile.
Filiaciones:
Fernandez-Diaz, E:
Complejo Hosp Univ Albacete, Neurol Dept, Albacete, Spain
Perez-Vicente, J:
Hosp Univ Santa Lucia, Neurol Dept, Cartagena, Colombia
Villaverde-Gonzalez, R:
Hosp Morales & Meseguer, Sect Neurol, Murcia, Spain
Berenguer-Ruiz, L:
Hosp Marina Baixa, Sect Neurol, La Vila Joiosa, Spain
Merlicco, A:
Hosp Rafael Mendez, Sect Neurol, Lorca, Spain
Martinez-Navarro, M:
Hosp Reina Sofia, Sect Neurol, Murcia, Spain
Gil, J:
Complejo Hosp Univ Albacete, Neurol Dept, Albacete, Spain
Romero-Sanchez, C:
Complejo Hosp Univ Albacete, Neurol Dept, Albacete, Spain
Alfaro-Saez, A:
Hosp Vega Baja, Sect Neurol, Orihuela, Spain
Ctr Biomed Res Network Bioengn Biomat & Nanomed C, Elche, Spain
Diaz, I:
Hosp Univ Santa Lucia, Neurol Dept, Cartagena, Colombia
Gimenez-Martinez, J:
Hosp Gen Univ Alicante, Alicante, Spain
Mendez-Miralles, M:
Hosp Univ Los Arcos Mar Menor, Sect Neurol, Murcia, Spain
Univ Catolica Murcia UCAM, Murcia, Spain
Millan-Pascual, J:
Hosp Univ Santa Lucia, Neurol Dept, Cartagena, Colombia
Jimenez-Pancho, J:
Hosp Vega Baja, Sect Neurol, Orihuela, Spain
Mola, S:
Hosp Vega Baja, Sect Neurol, Orihuela, Spain
:
Hosp Gen Univ Alicante, Alicante, Spain
Miguel Hernandez Univ, Dept Clin Med, Alacant, Spain
ISABIAL, Alicante, Spain
Gold, Green Published
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