Statin consumption and risk of post-endoscopic retrograde cholangiopancreatography pancreatitis
Por:
Martinez-Moneo, E, Cardenas-Jaen, K, Fernandez-Laso, A, Millastre-Bocos, J, Torralba-Gallego, A, Martin-Arriero, S, Alfaro-Almajano, E, Garcia-Rayado, G and De-Madaria, E
Publicada:
1 jul 2020
Ahead of Print:
7 may 2020
Resumen:
Background: The most frequent complication of endoscopic retrograde cholangiopancreatography (ERCP) is post-ERCP acute pancreatitis (PEP). Statin consumption seems to lower the incidence of acute pancreatitis. We aimed to investigate the relationship between the use of statins and the incidence of PEP.
Methods: multicenter (4 Spanish tertiary-level public hospitals) retrospective cohort study. Adult patients undergoing an ERCP were included in the study. We excluded patients with chronic pancreatitis, with ongoing acute pancreatitis and those who developed other complications after ERCP. Patients were classified into 2 groups: those under statin treatment (group S) and controls (group C). A multivariate analysis was performed (binary logistic regression) including age, center, female gender, previous pancreatitis, suspected sphincter of Oddi dysfunction, difficult cannulation (>10 min), >1 pancreatic guidewire passages, pancreatic injection, pancreatic stenting and presence of choledocholitiasis.
Results: seven hundred and two patients were included, median age 74 (62-82 years), 330 (47%) females, 223 (32%) in group S. Thirty-five (5%) patients developed PEP, 6 (3%) in group S and 29 (6%) in group C. Statin use was not associated with a lower frequency of PEP in univariate analysis, OR 0.429 (95% confidence interval 0.176-1.05, p = 0.06) or in multivariate analysis, adjusted OR 0.5 (0.19-1.32), p = 0.16. Statin use had no effect on severity of PEP, being mild in 50% vs 78.6% in non-statin users, p = 0.306.
Conclusions: the chronic use of statins was not associated with a decreased risk of PEP or a milder course of disease in our sample of patients. (c) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.
Filiaciones:
Martinez-Moneo, E:
Cruces Univ Hosp, Gastroenterol Dept, Baracaldo, Vizcaya, Spain
:
Alicante Univ Gen Hosp, Gastroenterol Dept, Alicante Inst Hlth & Biomed Res ISABIAL, Alicante, Spain
Fernandez-Laso, A:
Hosp Univ Araba, Gastroenterol Dept, Alava, Spain
Millastre-Bocos, J:
Hosp Clin Univ Lozano Blesa, Gastroenterol Dept, Aragon Hlth Res Inst ISS Aragon, Zaragoza, Spain
Torralba-Gallego, A:
Cruces Univ Hosp, Gastroenterol Dept, Baracaldo, Vizcaya, Spain
Martin-Arriero, S:
Hosp Univ Araba, Gastroenterol Dept, Alava, Spain
Alfaro-Almajano, E:
Hosp Clin Univ Lozano Blesa, Gastroenterol Dept, Aragon Hlth Res Inst ISS Aragon, Zaragoza, Spain
Garcia-Rayado, G:
Hosp Clin Univ Lozano Blesa, Gastroenterol Dept, Aragon Hlth Res Inst ISS Aragon, Zaragoza, Spain
:
Alicante Univ Gen Hosp, Gastroenterol Dept, Alicante Inst Hlth & Biomed Res ISABIAL, Alicante, Spain
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