Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors
Por:
Juanola, O, Martinez-Lopez, S, Frances, R and Gomez-Hurtado, I
Publicada:
1 may 2021
Ahead of Print:
14 may 2021
Resumen:
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver disease in the Western world, probably due to the growing prevalence of obesity, metabolic diseases, and exposure to some environmental agents. In certain patients, simple hepatic steatosis can progress to non-alcoholic steatohepatitis (NASH), which can sometimes lead to liver cirrhosis and its complications including hepatocellular carcinoma. Understanding the mechanisms that cause the progression of NAFLD to NASH is crucial to be able to control the advancement of the disease. The main hypothesis considers that it is due to multiple factors that act together on genetically predisposed subjects to suffer from NAFLD including insulin resistance, nutritional factors, gut microbiota, and genetic and epigenetic factors. In this article, we will discuss the epidemiology of NAFLD, and we overview several topics that influence the development of the disease from simple steatosis to liver cirrhosis and its possible complications.
Filiaciones:
:
Univ Svizzera Italiana, Ente Osped Cantonale, Translat Res Lab, Gastroenterol & Hepatol, CH-6900 Lugano, Switzerland
:
Miguel Hernandez Univ, Clin Med Dept, Alacant 03550, Spain
Hosp Gen Univ Alicante, Alicante Inst Hlth & Biomed Res ISABIAL, Alicante 03010, Spain
:
Miguel Hernandez Univ, Clin Med Dept, Alacant 03550, Spain
Hosp Gen Univ Alicante, Alicante Inst Hlth & Biomed Res ISABIAL, Alicante 03010, Spain
Inst Hlth Carlos III, Networked Biomed Res Ctr Hepat & Digest Dis CIBER, Madrid 28029, Spain
:
Hosp Gen Univ Alicante, Alicante Inst Hlth & Biomed Res ISABIAL, Alicante 03010, Spain
Inst Hlth Carlos III, Networked Biomed Res Ctr Hepat & Digest Dis CIBER, Madrid 28029, Spain
Gold, Green Published
|