Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
Por:
Belinchon-Romero, I, Bellot, P, Romero-Perez, D, Herraiz-Romero, I, Marco, F, Frances, R and Ramos-Rincon, J
Publicada:
21 abr 2021
Ahead of Print:
21 abr 2021
Resumen:
Psoriasis and non-alcoholic fatty liver disease (NAFLD) are both inflammatory diseases. The study objective was to estimate the risk of NAFLD, non-alcoholic steatohepatitis, and liver fibrosis (by liver stiffness and liver biopsy) in patients with psoriasis and to determine the epidemiological, clinical, immunological (TNF-alpha, IL-2, IL-6, IL-12, IL-17, IL-23, and TGF-beta) characteristics, and bacterial translocation. Of the 215 psoriatic patients included, 91 presented NAFLD (prevalence: 42.3%). Compared to patients with psoriasis alone, those with NAFLD were significantly more likely to have metabolic syndrome, diabetes, dyslipidemia, body mass index >= 30 kg/m(2), homeostatic model assessment of insulin resistance >= 2.15, and greater psoriasis area severity index. NAFLD patients also had significantly higher levels of TNF-alpha (p=0.002) and TGF-beta (p=0.007) and a higher prevalence of bacterial translocation (29.7% vs. 13.7%; p=0.004). Liver stiffness measurement was over 7.8 kPa in 17.2% (15/87) of NAFLD patients; 13 of these underwent liver biopsy, and 5.7% (5/87) had liver fibrosis, while 1.1% (1/87) had advanced fibrosis or non-alcoholic steatohepatitis. In conclusion the prevalence of NAFLD in patients with psoriasis is high and associated with a higher prevalence of metabolic syndrome features, bacterial translocation and a higher pro-inflammatory state. It is worth mentioning that liver fibrosis and non-alcoholic steatohepatitis are not frequent in this population of patients.
Filiaciones:
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Univ Gen Hosp Alicante, Dermatol Dept, C Pintor Baeza 12, Alicante 03010, Spain
Alicante Inst Sanit & Biomed Res ISABIAL, C Pintor Baeza 12, Alicante 03010, Spain
Miguel Hernandez Univ Elche, Clin Med Dept, Elche, Spain
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Alicante Inst Sanit & Biomed Res ISABIAL, C Pintor Baeza 12, Alicante 03010, Spain
Univ Gen Hosp Alicante, Digest Med Dept, Alicante, Spain
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Hosp Quiron Salud, Dermatol Unit, Tenerife, Spain
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Alicante Inst Sanit & Biomed Res ISABIAL, C Pintor Baeza 12, Alicante 03010, Spain
Univ Gen Hosp Alicante, Radiodiagnost Dept, Alicante, Spain
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Alicante Inst Sanit & Biomed Res ISABIAL, C Pintor Baeza 12, Alicante 03010, Spain
Univ Gen Hosp Alicante, Immunol Dept, Alicante, Spain
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Alicante Inst Sanit & Biomed Res ISABIAL, C Pintor Baeza 12, Alicante 03010, Spain
Miguel Hernandez Univ Elche, Clin Med Dept, Elche, Spain
Univ Gen Hosp Alicante, Res Inst, Alicante, Spain
Inst Salud Carlos III, CIBERehd, Madrid, Spain
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Miguel Hernandez Univ Elche, Clin Med Dept, Elche, Spain
Univ Gen Hosp Alicante ISABIAL, Internal Med Dept, Alicante, Spain
Gold, Green Published
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