Milk and Dairy Products Intake Is Related to Cognitive Impairment at Baseline in Predimed Plus Trial
Por:
Munoz-Garach, A, Cornejo-Pareja, I, Martinez-Gonzalez, M, Bullo, M, Corella, D, Castaner, O, Romaguera, D, Vioque, J, Alonso-Gomez, A, Warnberg, J, Martinez, J, Serra-Majem, L, Estruch, R, Bernal-Lopez, M, Lapetra, J, Pinto, X, Tur, J, Lopez-Miranda, J, Bueno-Cavanillas, A, Delgado-Rodriguez, M, Matia-Martin, P, Daimiel, L, Sanchez, V, Vidal, J, Prieto, L, Ros, E, Fernandez-Aranda, F, Camacho-Barcia, L, Ortega-Azorin, C, Soria, M, Fiol, M, Compan-Gabucio, L, Goicolea-Guemez, L, Perez-Lopez, J, Goni, N, Perez-Cabrera, J, Sacanella, E, Fernandez-Garcia, J, Miro-Moriano, L, Gimenez-Gracia, M, Razquin, C, Paz-Graniel, I, Guillem, P, Zomeno, M, Monino, M, Oncina-Canovas, A, Salaverria-Lete, I, Toledo, E, Salas-Salvado, J, Schroder, H, Tinahones, F and Predimed
Publicada:
1 abr 2021
Ahead of Print:
1 mar 2021
Resumen:
Scope To examine the association between milk and dairy products intake and the prevalence of cognitive decline among Spanish individuals at high cardiovascular risk.
Methods and results Cross-sectional analyses are performed on baseline data from 6744 adults (aged 55-75 years old). Intake of milk and dairy products is estimated using a food frequency questionnaire grouped into quartiles. The risk of developing cognitive impairment is based on the Mini-Mental State Examination (MMSE).
A higher prevalence of cognitive decline was found in subjects who consumed more grams. Patients with worse MMSE score (10-24) consumed a mean of 395.14 +/- 12.21 g, while patients with better MMSE score (27-30) consumed a mean of 341.23 +/- 2.73 g (p < 0.05). Those subjects with the lower milk consumption (<220 g/day) had a higher MMSE score (28.35 +/- 0.045). Higher intake of fermented dairy products was observed in participants with a lower MMSE score (OR 1.340, p = 0.003). A positive correlation was found between the consumption of whole milk and the MMSE score (r = 0.066, p < 0.001).
Conclusions These findings suggest that greater consumption of milk and dairy products could be associated with greater cognitive decline according to MMSE. Conversely, consumption of whole-fat milk could be linked with less cognitive impairment in the cross-sectional study.
Filiaciones:
Munoz-Garach, A:
Virgen Victoria Univ Hosp, Dept Endocrinol & Nutr, IBIMA, Avda Teatinos S-N, Malaga 29010, Spain
Cornejo-Pareja, I:
Virgen Victoria Univ Hosp, Dept Endocrinol & Nutr, IBIMA, Avda Teatinos S-N, Malaga 29010, Spain
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Martinez-Gonzalez, M:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, C Irunlarrea 1, Navarra 31008, Spain
Harvard TH Chan Sch Publ Health, Dept Nutr, 665 Huntington Ave Boston, Massachusetts, MA 02115 USA
Bullo, M:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr, Campus Sescelades C Marceli Domingo 1, Tarragona 43007, Spain
Univ Hosp St Joan Reus, Nutr Unit, Avinguda Doctor Josep Laporte 2, Tarragona 43204, Spain
IISPV, Carrer Dr Mallafre Guasch 4, Tarragona 43007, Spain
Corella, D:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Valencia., Dept Prevent Med, Av Blasco Ibanez 13, Valencia 46010, Spain
Castaner, O:
Inst Hosp Mar Invest Med Municipal Invest Med IMI, Unit Cardiovasc Risk & Nutr, Carrer Dr Aiguader 88, Barcelona 08003, Spain
Romaguera, D:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Carretera Valldemossa 79, Palma De Mallorca 07120, Balearic Island, Spain
:
Inst Salud Carlos III, CIBER Epidmiol Salud Publ CIBERESP, C Monforte Lemos 5, Madrid 28029, Spain
Miguel Hernandez Univ, ISABIAL, FISABIO, Avda Pintor Baeza 12 HGUA,Ctr Diagnost,Planta 5, Alicante 03010, Spain
Alonso-Gomez, A:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Hosp Araba, Dept Cardiol, OSI ARABA, C Jose Atxotegi Kalea S-N, Araba Vitoria Gasteiz ARABA, Spain
Univ Basque Country, UPV EHU, C Nieves Cano Kalea 12, Araba Vitoria Gasteiz 01006, Spain
Warnberg, J:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Malaga, Dept Nursing, Sch Hlth Sci, Calle Severo Ochoa 63, Malaga 29590, Spain
Martinez, J:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, C Irunlarrea 1, Navarra 31008, Spain
CEI UAM, IMDEA Food, Nutrit Genom & Epigen Grp, CSIC, Crta Carr Canto Blanco,8, Madrid 28049, Spain
Serra-Majem, L:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Palmas Gran Canaria, Nutr Res Grp, Res Inst Biomed & Hlth Sci IUIBS, IUIBS, Paseo Blas Cabrera Felipe Fis S-N, Las Palmas Gran Canaria 35016, Spain
Estruch, R:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Barcelona, Hosp Clin, Dept Internal Med, IDIBAPS, Carrer Rossello 149, Barcelona 08036, Spain
Bernal-Lopez, M:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Reg Univ Hosp Malaga, Dept Internal Med, IBIMA, Plaza Hosp Civil S-N, Malaga 29009, Spain
Lapetra, J:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Av Ramon & Cajal 9, Seville 41005, Spain
Pinto, X:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Barcelona, Lipids & Vasc Risk Unit, Internal Med, Hosp Univ BellvitgeIDIBELL, Carrer Feixa Llarga S-N, Barcelona 08907, Spain
Univ Barcelona, Med Dept, Calle Gran Via Corts Catalanes 585, Barcelona 08007, Spain
Tur, J:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Balear Islands, Res Grp Community Nutr & Oxidat Stress, Carretera Valldemossa Km 7-5, Palma De Mallorca 07122, Spain
Lopez-Miranda, J:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Cordoba, Reina Sofia Univ Hosp, Dept Internal Med, Maimonides Biomed Res Inst Cordoba IMIBIC, Menendez Pidal S-N, Cordoba 14004, Spain
Bueno-Cavanillas, A:
Inst Salud Carlos III, CIBER Epidmiol Salud Publ CIBERESP, C Monforte Lemos 5, Madrid 28029, Spain
Univ Granada, Dept Prevent Med & Publ Hlth, Av Hosp 1, Granada 18010, Spain
Delgado-Rodriguez, M:
Inst Salud Carlos III, CIBER Epidmiol Salud Publ CIBERESP, C Monforte Lemos 5, Madrid 28029, Spain
Univ Jaen, Fac Med, Div Prevent Med, Campus Lagunillas S-N, Jaen 23071, Spain
Matia-Martin, P:
Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Calle Prof Martin Lagos S-N, Madrid 28040, Spain
Daimiel, L:
CEI UAM, IMDEA Food, Nutrit Genom & Epigen Grp, CSIC, Crta Carr Canto Blanco,8, Madrid 28049, Spain
Sanchez, V:
Inst Salud Carlos III, CIBER Epidmiol Salud Publ CIBERESP, C Monforte Lemos 5, Madrid 28029, Spain
Univ Leon, Inst BioMed, IBIOMED, Campus Univ Vegazana S-N, Leon 24071, Spain
Vidal, J:
Instituto Salud Carlos III, ISCIII, CIBER Diabet Enfermedades Metabol CIBERDEM, C Monforte Lemos 5, Madrid 28029, Spain
Univ Barcelona, Hosp Clin, IDIBAPS, Dept Endocrinol, Carrer Rossello 149, Barcelona 08036, Spain
Prieto, L:
Fdn Jimenez Diaz, Dept Endocrinol, Av Reyes Catolicos 2, Madrid 28040, Spain
Ros, E:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Hosp Clin Barcelona, Dept Endocrinol & Nutr, Inst Invest Biomed August Pi Sunyer IDIBAPS, Carrer Rossello 149, Barcelona 08036, Spain
Fernandez-Aranda, F:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Barcelona, Dept Psychiat, Univ Hosp Bellvitge IDIBELL, Campus Bellvitge,Feixa Llarga S-N, Barcelona 08907, Spain
Univ Barcelona, Dept Clin Sci, Sch Med & Hlth Sci, Campus Bellvitge,Feixa Llarga S-N, Barcelona 08907, Spain
Camacho-Barcia, L:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr, Campus Sescelades C Marceli Domingo 1, Tarragona 43007, Spain
Univ Hosp St Joan Reus, Nutr Unit, Avinguda Doctor Josep Laporte 2, Tarragona 43204, Spain
IISPV, Carrer Dr Mallafre Guasch 4, Tarragona 43007, Spain
Ortega-Azorin, C:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Valencia., Dept Prevent Med, Av Blasco Ibanez 13, Valencia 46010, Spain
Soria, M:
Inst Hosp Mar Invest Med Municipal Invest Med IMI, Unit Cardiovasc Risk & Nutr, Carrer Dr Aiguader 88, Barcelona 08003, Spain
Fiol, M:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Carretera Valldemossa 79, Palma De Mallorca 07120, Balearic Island, Spain
:
Inst Salud Carlos III, CIBER Epidmiol Salud Publ CIBERESP, C Monforte Lemos 5, Madrid 28029, Spain
Miguel Hernandez Univ, ISABIAL, FISABIO, Avda Pintor Baeza 12 HGUA,Ctr Diagnost,Planta 5, Alicante 03010, Spain
Goicolea-Guemez, L:
Univ Hosp Araba, Dept Cardiol, OSI ARABA, C Jose Atxotegi Kalea S-N, Araba Vitoria Gasteiz ARABA, Spain
Perez-Lopez, J:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Malaga, Dept Nursing, Sch Hlth Sci, Calle Severo Ochoa 63, Malaga 29590, Spain
Goni, N:
Navarro Hlth Serv, Primary Care Pamplona, Plaza Paz S-N, Navarra 31002, Spain
Perez-Cabrera, J:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Palmas Gran Canaria, Nutr Res Grp, Res Inst Biomed & Hlth Sci IUIBS, IUIBS, Paseo Blas Cabrera Felipe Fis S-N, Las Palmas Gran Canaria 35016, Spain
Sacanella, E:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Barcelona, Hosp Clin, Dept Internal Med, IDIBAPS, Carrer Rossello 149, Barcelona 08036, Spain
Fernandez-Garcia, J:
Virgen Victoria Univ Hosp, Dept Endocrinol & Nutr, IBIMA, Avda Teatinos S-N, Malaga 29010, Spain
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Miro-Moriano, L:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Av Ramon & Cajal 9, Seville 41005, Spain
Gimenez-Gracia, M:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Av Ramon & Cajal 9, Seville 41005, Spain
Razquin, C:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, C Irunlarrea 1, Navarra 31008, Spain
Harvard TH Chan Sch Publ Health, Dept Nutr, 665 Huntington Ave Boston, Massachusetts, MA 02115 USA
Paz-Graniel, I:
Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr, Campus Sescelades C Marceli Domingo 1, Tarragona 43007, Spain
Univ Hosp St Joan Reus, Nutr Unit, Avinguda Doctor Josep Laporte 2, Tarragona 43204, Spain
Guillem, P:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Valencia., Dept Prevent Med, Av Blasco Ibanez 13, Valencia 46010, Spain
Zomeno, M:
Inst Hosp Mar Invest Med Municipal Invest Med IMI, Unit Cardiovasc Risk & Nutr, Carrer Dr Aiguader 88, Barcelona 08003, Spain
Monino, M:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Carretera Valldemossa 79, Palma De Mallorca 07120, Balearic Island, Spain
:
Inst Salud Carlos III, CIBER Epidmiol Salud Publ CIBERESP, C Monforte Lemos 5, Madrid 28029, Spain
Miguel Hernandez Univ, ISABIAL, FISABIO, Avda Pintor Baeza 12 HGUA,Ctr Diagnost,Planta 5, Alicante 03010, Spain
Salaverria-Lete, I:
Univ Hosp Araba, Dept Cardiol, OSI ARABA, C Jose Atxotegi Kalea S-N, Araba Vitoria Gasteiz ARABA, Spain
Toledo, E:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, C Irunlarrea 1, Navarra 31008, Spain
Harvard TH Chan Sch Publ Health, Dept Nutr, 665 Huntington Ave Boston, Massachusetts, MA 02115 USA
Salas-Salvado, J:
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr, Campus Sescelades C Marceli Domingo 1, Tarragona 43007, Spain
Univ Hosp St Joan Reus, Nutr Unit, Avinguda Doctor Josep Laporte 2, Tarragona 43204, Spain
IISPV, Carrer Dr Mallafre Guasch 4, Tarragona 43007, Spain
Schroder, H:
Inst Hosp Mar Invest Med Municipal Invest Med IMI, Unit Cardiovasc Risk & Nutr, Carrer Dr Aiguader 88, Barcelona 08003, Spain
Inst Salud Carlos III, CIBER Epidmiol Salud Publ CIBERESP, C Monforte Lemos 5, Madrid 28029, Spain
Tinahones, F:
Virgen Victoria Univ Hosp, Dept Endocrinol & Nutr, IBIMA, Avda Teatinos S-N, Malaga 29010, Spain
Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, C Monforte Lemos 5, Madrid 28029, Spain
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