Self-Reported DHA Supplementation during Pregnancy and Its Association with Obesity or Gestational Diabetes in Relation to DHA Concentration in Cord and Maternal Plasma: Results from NELA, a Prospective Mother-Offspring Cohort
Por:
Gazquez, A, Gimenez-Banon, M, Prieto-Sanchez, M, Martinez-Gracia, C, Suarez, C, Santaella-Pascual, M, Galdo-Castineira, L, Ballesteros-Meseguer, C, Vioque, J, Martinez-Villanueva, M, Aviles-Plaza, F, Noguera-Velasco, J, Morales, E, Garcia-Marcos, L, Larque, E and Nela Study Grp
Publicada:
1 mar 2021
Ahead of Print:
4 mar 2021
Resumen:
Maternal supplementation of docosahexaenoic acid (DHA) during pregnancy has been recommended due to its role in infant development, but its effect on materno-fetal DHA status is not well established. We evaluated the associations between DHA supplementation in pregnant women with obesity or gestational diabetes mellitus (GDM) and maternal and neonatal DHA status. Serum fatty acids (FA) were analyzed in 641 pregnant women (24 weeks of gestation) and in 345 venous and 166 arterial cord blood samples of participants of the NELA cohort. Obese women (n = 47) presented lower DHA in serum than those lean (n = 397) or overweight (n = 116) before pregnancy. Linoleic acid in arterial cord was elevated in obese women, which indicates lower fetal retention. Maternal DHA supplementation (200 mg/d) during pregnancy was associated with enhanced maternal and fetal DHA levels regardless of pre-pregnancy body mass index (BMI), although higher arterial DHA in overweight women indicated an attenuated response. Maternal DHA supplementation was not associated with cord venous DHA in neonates of mothers with GDM. The cord arteriovenous difference was similar for DHA between GDM and controls. In conclusion, maternal DHA supplementation during pregnancy enhanced fetal DHA status regardless of the pre-pregnancy BMI while GDM may reduce the effect of DHA supplementation in newborns.
Filiaciones:
Gazquez, A:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Dept Physiol, Murcia 30100, Spain
Gimenez-Banon, M:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Dept Physiol, Murcia 30100, Spain
Prieto-Sanchez, M:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Virgen de la Arrixaca Univ Clin Hosp, Obstet & Gynaecol Serv, Murcia 30120, Spain
Martinez-Gracia, C:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Fac Vet, Food Sci & Technol Dept, Murcia 30100, Spain
Suarez, C:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Fac Vet, Food Sci & Technol Dept, Murcia 30100, Spain
Santaella-Pascual, M:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Fac Vet, Food Sci & Technol Dept, Murcia 30100, Spain
Galdo-Castineira, L:
Univ Murcia, Virgen de la Arrixaca Univ Clin Hosp, Obstet & Gynaecol Serv, Murcia 30120, Spain
Ballesteros-Meseguer, C:
Univ Murcia, Virgen de la Arrixaca Univ Clin Hosp, Obstet & Gynaecol Serv, Murcia 30120, Spain
:
Hlth & Biomed Res Inst Alicante ISABIAL UMH, Alicante 46020, Spain
CIBER Epidemiol & Publ Hlth CIBERESP, Madrid 28029, Spain
Martinez-Villanueva, M:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Univ Clin Hosp Virgen de la Arrixaca, Clin Anal Serv, Mol Therapy & Biomarkers Res Grp, Murcia 30120, Spain
Aviles-Plaza, F:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Univ Clin Hosp Virgen de la Arrixaca, Clin Anal Serv, Mol Therapy & Biomarkers Res Grp, Murcia 30120, Spain
Noguera-Velasco, J:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Univ Clin Hosp Virgen de la Arrixaca, Clin Anal Serv, Mol Therapy & Biomarkers Res Grp, Murcia 30120, Spain
Morales, E:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Dept Publ Hlth Sci, Murcia 30100, Spain
Garcia-Marcos, L:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Network Asthma & Adverse & Allerg React ARADyAL, Madrid 28029, Spain
Larque, E:
Biomed Res Inst Murcia IMIB Arrixaca, Murcia 30120, Spain
Univ Murcia, Dept Physiol, Murcia 30100, Spain
Gold, Green Published
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