Fast-Track Liver Transplantation: Six-year Prospective Cohort Study with an Enhanced Recovery After Surgery (ERAS) Protocol
Por:
Rodriguez-Laiz, G, Melgar-Requena, P, Alcazar-Lopez, C, Franco-Campello, M, Villodre-Tudela, C, Pascual-Bartolome, S, Bellot-Garcia, P, Rodriguez-Soler, M, Miralles-Macia, C, Mas-Serrano, P, Navarro-Martinez, J, Martinez-Adsuar, F, Gomez-Salinas, L, Jaime-Sanchez, F, Perdiguero-Gil, M, Diaz-Cuevas, M, Palazon-Azorin, J, Such-Ronda, J, Lluis-Casajuana, F and Ramia-Angel, J
Publicada:
1 may 2021
Ahead of Print:
1 feb 2021
Resumen:
Introduction Enhanced recovery after surgery (ERAS) has been shown to facilitate discharge, decrease length of stay, improve outcomes and reduce costs. We used this concept to design a comprehensive fast-track pathway (OR-to-discharge) before starting our liver transplant activity and then applied this protocol prospectively to every patient undergoing liver transplantation at our institution, monitoring the results periodically. We now report our first six years results. Patients and methods Prospective cohort study of all the liver transplants performed at our institution for the first six years. Balanced general anesthesia, fluid restriction, thromboelastometry, inferior vena cava preservation and temporary portocaval shunt were strategies common to all cases. Standard immunosuppression administered included steroids, tacrolimus (delayed in the setting of renal impairment, with basiliximab induction added) and mycophenolate mofetil. Tacrolimus dosing was adjusted using a Bayesian estimation methodology. Oral intake and ambulation were started early. Results A total of 240 transplants were performed in 236 patients (191 male/45 female) over 74 months, mean age 56.3 +/- 9.6 years, raw MELD score 15.5 +/- 7.7. Predominant etiologies were alcohol (n = 136) and HCV (n = 82), with hepatocellular carcinoma present in 129 (54.7%). Nine patients received combined liver and kidney transplants. The mean operating time was 315 +/- 64 min with cold ischemia times of 279 +/- 88 min. Thirty-one patients (13.1%) were transfused in the OR (2.4 +/- 1.2 units of PRBC). Extubation was immediate (< 30 min) in all but four patients. Median ICU length of stay was 12.7 hours, and median post-transplant hospital stay was 4 days (2-76) with 30 patients (13.8%) going home by day 2, 87 (39.9%) by day 3, and 133 (61%) by day 4, defining our fast-track group. Thirty-day-readmission rate (34.9%) was significantly lower (28.6% vs. 44.7% p=0.015) in the fast-track group. Patient survival was 86.8% at 1 year and 78.6% at five years. Conclusion Fast-Tracking of Liver Transplant patients is feasible and can be applied as the standard of care
Filiaciones:
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Hosp Gen Univ Alicante, Hepatobiliary Surg & Liver Transplantat, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Hepatobiliary Surg & Liver Transplantat, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Hepatobiliary Surg & Liver Transplantat, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Hepatobiliary Surg & Liver Transplantat, Alicante, Spain
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Hosp Gen Univ Alicante, Hepatobiliary Surg & Liver Transplantat, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Hepatol & Liver Unit, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Hepatol & Liver Unit, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Hepatol & Liver Unit, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Hepatol & Liver Unit, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Pharm & Pharmacokinet, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Anesthesiol & Surg Crit Care, Alicante, Spain
Martinez-Adsuar, F:
Hosp Marina Baja, Anesthesiol & Surg Crit Care, Alicante, Spain
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Hosp Gen Univ Alicante, Anesthesiol & Surg Crit Care, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
Jaime-Sanchez, F:
Hosp Gen Univ Alicante, Crit Care Med, Alicante, Spain
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Hosp Gen Univ Alicante, Nephrol & Renal Transplantat, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Nephrol & Renal Transplantat, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
Palazon-Azorin, J:
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
Such-Ronda, J:
Cleveland Clin Abu Dhabi, Digest Dis Inst, Abu Dhabi, U Arab Emirates
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ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
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Hosp Gen Univ Alicante, Hepatobiliary Surg & Liver Transplantat, Alicante, Spain
ISABIAL Alicante Inst Hlth & Biomed Res, Alicante, Spain
Green Published, Hybrid Gold
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