Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
Por:
Sanchez-Castro, E, Pajuelo-Reyes, C, Tejedo, R, Soria-Juan, B, Tapia-Limonchi, R, Andreu, E, Hitos, A, Martin, F, Cahuana, G, Guerra-Duarte, C, de Assis, T, Bedoya, F, Soria, B, Chavez-Olortegui, C and Tejedo, J
Publicada:
3 feb 2021
Ahead of Print:
3 feb 2021
Resumen:
Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects. Local damage, such as dermonecrosis and myonecrosis, can lead to permanent sequelae with physical, social, and psychological implications. The strong inflammatory process induced by snake venoms is associated with poor tissue regeneration, in particular the lack of or reduced skeletal muscle regeneration. Mesenchymal stromal cells (MSCs)-based therapies have shown both anti-inflammatory and pro-regenerative properties. We postulate that using allogeneic MSCs or their cell-free products can induce skeletal muscle regeneration in snakebite victims, improving all the three steps of the skeletal muscle regeneration process, mainly by anti-inflammatory activity, paracrine effects, neovascularization induction, and inhibition of tissue damage, instrumental for microenvironment remodeling and regeneration. Since snakebite envenoming occurs mainly in areas with poor healthcare, we enlist the principles and potential of MSCs-based therapies and discuss regulatory issues, good manufacturing practices, transportation, storage, and related-procedures that could allow the administration of these therapies, looking forward to a safe and cost-effective treatment for a so far unsolved and neglected health problem.
Filiaciones:
Sanchez-Castro, E:
Univ Nacl Mayor San Marcos, Fac Biol Sci, Lima, Peru
Pajuelo-Reyes, C:
Univ Nacl Toribio Rodriguez de Mendoza Amazonas, Inst Trop Dis, Chachapoyas, Peru
Tejedo, R:
Univ Privada San Juan Bautista, Fac Med, Lima, Peru
Soria-Juan, B:
Univ Pablo de Olavide, Dept Mol Biol & Biochem Engn, Seville, Spain
Univ Autonoma Madrid, Fdn Jimenez Diaz, Dept Surg, Unidad Terapias Avanzadas, Madrid, Spain
Tapia-Limonchi, R:
Univ Nacl Toribio Rodriguez de Mendoza Amazonas, Inst Trop Dis, Chachapoyas, Peru
:
ISABIAL Hosp Gen & Univ Alicante, Alicante, Spain
Univ Miguel Hernandez, Dept Fis Aplicadas, Alicante, Spain
Hitos, A:
Univ Pablo de Olavide, Univ Sevilla, Dept Cell Regenerat & Adv Therapies,CSIC, Andalusian Ctr Mol Biol & Regenerat Med CABIMER, Seville, Spain
Inst Salud Carlos III, Biomed Res Network Diabet & Related Metab Dis CIB, Madrid, Spain
Martin, F:
Univ Pablo de Olavide, Dept Mol Biol & Biochem Engn, Seville, Spain
Univ Pablo de Olavide, Univ Sevilla, Dept Cell Regenerat & Adv Therapies,CSIC, Andalusian Ctr Mol Biol & Regenerat Med CABIMER, Seville, Spain
Inst Salud Carlos III, Biomed Res Network Diabet & Related Metab Dis CIB, Madrid, Spain
Cahuana, G:
Univ Pablo de Olavide, Dept Mol Biol & Biochem Engn, Seville, Spain
Univ Pablo de Olavide, Univ Sevilla, Dept Cell Regenerat & Adv Therapies,CSIC, Andalusian Ctr Mol Biol & Regenerat Med CABIMER, Seville, Spain
Guerra-Duarte, C:
Fundacao Ezequiel Dias, Ctr Res & Dev, Belo Horizonte, MG, Brazil
de Assis, T:
Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil
Bedoya, F:
Univ Pablo de Olavide, Dept Mol Biol & Biochem Engn, Seville, Spain
Univ Pablo de Olavide, Univ Sevilla, Dept Cell Regenerat & Adv Therapies,CSIC, Andalusian Ctr Mol Biol & Regenerat Med CABIMER, Seville, Spain
Inst Salud Carlos III, Biomed Res Network Diabet & Related Metab Dis CIB, Madrid, Spain
:
Univ Pablo de Olavide, Dept Mol Biol & Biochem Engn, Seville, Spain
ISABIAL Hosp Gen & Univ Alicante, Alicante, Spain
Inst Salud Carlos III, Biomed Res Network Diabet & Related Metab Dis CIB, Madrid, Spain
Univ Miguel Hernandez Elche, Inst Bioengn, Alicante, Spain
Chavez-Olortegui, C:
Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil
Tejedo, J:
Univ Nacl Toribio Rodriguez de Mendoza Amazonas, Inst Trop Dis, Chachapoyas, Peru
Univ Pablo de Olavide, Dept Mol Biol & Biochem Engn, Seville, Spain
Univ Pablo de Olavide, Univ Sevilla, Dept Cell Regenerat & Adv Therapies,CSIC, Andalusian Ctr Mol Biol & Regenerat Med CABIMER, Seville, Spain
Inst Salud Carlos III, Biomed Res Network Diabet & Related Metab Dis CIB, Madrid, Spain
Gold, Green Published
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