The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4-5 Years of Age in the INMA Project
Por:
Gabucio, L, de la Hera, M, Collado, L, Fernandez-Somoano, A, Tardon, A, Guxens, M, Vrijheid, M, Rebagliato, M, Murcia, M, Ibarluzea, J, Marti, I and Vioque, J
Publicada:
1 feb 2021
Ahead of Print:
23 ene 2021
Resumen:
We assessed the association between the use of lower- and higher-than-recommended doses of folic acid supplements (FAs) during pregnancy and attentional function in boys and girls at age of 4-5. We analyzed data from 1329 mother-child pairs from the mother-child cohort INfancia y Medio Ambiente Project (INMA) study. Information on FAs use during pregnancy was collected in personal interviews at weeks 12 and 30, and categorized in <400, 400-999 (recommended dose), and >= 1000 mu g/day. Child attentional function was assessed by Conners' Kiddie Continuous Performance Test. Multivariable regression analyses were used to estimate incidence rate ratios (IRR) and beta coefficients with 95% confidence intervals (CI). Compared to recommended FAs doses, the periconceptional use of <400 and >= 1000 mu g/day was associated with higher risk of omission errors-IRR = 1.14 (95% CI: 1.01; 1.29) and IRR = 1.16 (95% CI: 1.02; 1.33), respectively. The use of FAs < 400 mu g/day and >= 1000 mu g/day was significantly associated with deficits of attentional function only in boys. FAs use < 400 mu g/day was associated with higher omission errors with IRR = 1.22 and increased hit reaction time (HRT) beta = 34.36, and FAs use >= 1000 mu g/day was associated with increased HRT beta = 33.18 and HRT standard error beta = 3.31. The periconceptional use of FAs below or above the recommended doses is associated with deficits of attentional function in children at age of 4-5, particularly in boys.
Filiaciones:
:
Inst Invest Sanit & Biomed Alicante, ISABIAL UMH, Alicante 03010, Spain
Univ Miguel Hernandez UMH, Dept Salud Publ Hist Ciencia & Ginecol, Unidad Epidemiol Nutr, Alicante 03550, Spain
:
Inst Invest Sanit & Biomed Alicante, ISABIAL UMH, Alicante 03010, Spain
Univ Miguel Hernandez UMH, Dept Salud Publ Hist Ciencia & Ginecol, Unidad Epidemiol Nutr, Alicante 03550, Spain
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28034, Spain
:
Inst Invest Sanit & Biomed Alicante, ISABIAL UMH, Alicante 03010, Spain
Univ Miguel Hernandez UMH, Dept Salud Publ Hist Ciencia & Ginecol, Unidad Epidemiol Nutr, Alicante 03550, Spain
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28034, Spain
Fernandez-Somoano, A:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28034, Spain
Univ Oviedo, IUOPA Dept Med, Oviedo 33003, Spain
Inst Invest Sanit Principado Asturias ISP, Dept Epidemiol Ambiental & Mol Canc, Roma Ave S-N, Oviedo 33001, Asturias, Spain
Tardon, A:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28034, Spain
Univ Oviedo, IUOPA Dept Med, Oviedo 33003, Spain
Inst Invest Sanit Principado Asturias ISP, Dept Epidemiol Ambiental & Mol Canc, Roma Ave S-N, Oviedo 33001, Asturias, Spain
Guxens, M:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28034, Spain
Barcelona Inst Global Hlth ISGlobal, Dept Childhood & Environm, Barcelona 08036, Spain
Univ Pompeu Fabra UPF, Dept Ciencies Expt & Salut, Barcelona 08002, Spain
Univ Med Ctr, Dept Child & Adolescent Psychiat, Erasmus MC, NL-3015 GD Rotterdam, Netherlands
Vrijheid, M:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28034, Spain
Barcelona Inst Global Hlth ISGlobal, Dept Childhood & Environm, Barcelona 08036, Spain
Univ Pompeu Fabra UPF, Dept Ciencies Expt & Salut, Barcelona 08002, Spain
Rebagliato, M:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28034, Spain
Univ Valencia, Fdn Promot Hlth & Biomed Res Valencian Reg, Epidemiol & Environm Hlth Joint Res Unit, FISABIO Publ Hlth,FISABIO Univ Jaume I, Valencia 46015, Spain
Univ Jaume 1, Dept Med, Castellon De La Plana 12071, Spain
Murcia, M:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28034, Spain
Univ Valencia, Fdn Promot Hlth & Biomed Res Valencian Reg, Epidemiol & Environm Hlth Joint Res Unit, FISABIO Publ Hlth,FISABIO Univ Jaume I, Valencia 46015, Spain
Generalitat Valenciana, Serv Anal Sistemas Informac Sanitaria, Conselleria Sanitat, Valencia 46010, Spain
Ibarluzea, J:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28034, Spain
Biodonostia Hlth Res Inst, Grp Environm Epidemiol, Donostia San Sebastian 20014, Spain
Minist Hlth Basque Govt, Sub Directorate Publ Hlth & Addict Gipuzkoa, San Sebastian 20013, Spain
Univ Basque Country UPV EHU, Sch Psychol, San Sebastian 20018, Spain
Marti, I:
Biodonostia Hlth Res Inst, Grp Environm Epidemiol, Donostia San Sebastian 20014, Spain
Osakidetza Basque Hlth Serv, Donostia Univ Hosp, Pediat Neurol Dept, San Sebastian 20014, Spain
:
Inst Invest Sanit & Biomed Alicante, ISABIAL UMH, Alicante 03010, Spain
Univ Miguel Hernandez UMH, Dept Salud Publ Hist Ciencia & Ginecol, Unidad Epidemiol Nutr, Alicante 03550, Spain
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28034, Spain
Gold, Green Published
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