Dietary inflammatory index of mothers during pregnancy and Attention Deficit-Hyperactivity Disorder symptoms in the child at preschool age: a prospective investigation in the INMA and RHEA cohorts
Por:
Lertxundi, N, Molinuevo, A, Valvi, D, Gorostiaga, A, Balluerka, N, Shivappa, N, Hebert, J, Navarrete-Munoz, E, Vioque, J, Tardon, A, Vrijheid, M, Roumeliotaki, T, Koutra, K, Chatzi, L and Ibarluzea, J
Publicada:
1 ene 2021
Ahead of Print:
1 ene 2021
Resumen:
Inflammation provides a substrate for mechanisms that underlie the association of maternal diet during pregnancy with Attention Deficit-Hyperactivity Disorder (ADHD) symptoms in childhood. However, no previous study has quantified the proinflammatory potential of maternal diet as a risk factor for ADHD. Thus, we evaluated the association of maternal dietary inflammatory index (DII(R)) scores during pregnancy with ADHD symptoms in 4-year-old children born in two Mediterranean regions. We analyzed data from two population-based birth cohort studies-INMA (Environment and Childhood) four subcohorts in Spain (N = 2097), and RHEA study in Crete (Greece) (N = 444). The DII score of maternal diet was calculated based on validated food frequency questionnaires completed during pregnancy (12th and/or 32nd week of gestation). ADHD symptoms were assessed by ADHD-DSM-IV in INMA cohort and by ADHDT test in RHEA cohort, with questionnaires filled-out by teachers and parents, respectively. The associations between maternal DII and ADHD symptoms were analysed using multivariable-adjusted zero-inflated negative binomial regression models in each cohort study separately. Meta-analysis was conducted to combine data across the cohorts for fitting within one model. The DII was significantly higher in RHEA (RHEA = 2.09 [1.94, 2.24]) in comparison to INMA subcohorts (Asturias = - 1.52 [- 1.67, - 1.38]; Gipuzkoa = - 1.48 [- 1.64, - 1.33]; Sabadell = - 0.95 [- 1.07, - 0.83]; Valencia = - 0.76 [- 0.90, - 0.62]). Statistically significant reduced risk of inattention symptomatology (OR = 0.86; CI 95% = 0.77-0.96), hyperactivity symptomatology (OR = 0.82; CI 95% = 0.72-0.92) and total ADHD symptomatology (OR = 0.82; CI 95% = - 0.72 to 0.93) were observed with increased maternal DII in boys. No statistically significant associations were observed in girls between maternal DII and inattention, hyperactivity and total ADHD symptomatology. We found reduced risk of ADHD symptomatology with increased DII only in boys. This relationship requires further exploration in other settings.
Filiaciones:
Lertxundi, N:
Univ Basque Country UPV EHU, Donostia San Sebastian, Spain
Hlth Res Inst BIODONOSTIA, Donostia San Sebastian, Spain
Molinuevo, A:
Publ Hlth Div Gipuzkoa, Donostia San Sebastian, Spain
Valvi, D:
Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA
Gorostiaga, A:
Univ Basque Country UPV EHU, Donostia San Sebastian, Spain
Hlth Res Inst BIODONOSTIA, Donostia San Sebastian, Spain
Balluerka, N:
Univ Basque Country UPV EHU, Donostia San Sebastian, Spain
Hlth Res Inst BIODONOSTIA, Donostia San Sebastian, Spain
Shivappa, N:
Univ South Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC 29208 USA
Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA
Connecting Hlth Innovat LLC, Columbia, SC USA
Hebert, J:
Univ South Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC 29208 USA
Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA
Connecting Hlth Innovat LLC, Columbia, SC USA
:
Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain
ISABIAL UMH, Inst Hlth & Biomed Res, Alicante, Spain
Miguel Hernandez Univ, Dept Surg & Pathol, Alicante, Spain
:
Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain
ISABIAL UMH, Inst Hlth & Biomed Res, Alicante, Spain
Tardon, A:
Univ Oviedo, IUOPA, Oviedo, Spain
ISPA, Oviedo, Spain
Vrijheid, M:
Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain
ISGlobal Inst Global Hlth, Barcelona, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Roumeliotaki, T:
Univ Crete, Sch Social Sci, Dept Psychol, Iraklion, Greece
Koutra, K:
Univ Crete, Sch Social Sci, Dept Psychol, Iraklion, Greece
Chatzi, L:
Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USA
Ibarluzea, J:
Univ Basque Country UPV EHU, Donostia San Sebastian, Spain
Hlth Res Inst BIODONOSTIA, Donostia San Sebastian, Spain
Publ Hlth Div Gipuzkoa, Donostia San Sebastian, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain
Green Accepted
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