Outcomes after venous thromboembolism in patients with gastric cancer: Analysis of the RIETE Registry
Por:
Majmudar, K, Golemi, I, Tafur, A, Del Toro, J, Visona, A, Falga, C, Sahuquillo, J, Lorente, M, Tufano, A, Weinberg, I, Monreal, M and RIETE Investigators
Publicada:
1 jun 2020
Ahead of Print:
1 ene 2020
Resumen:
Gastric cancer is the fifth most common malignancy worldwide. Venous thromboembolism is an independent predictor of death among patients with gastric cancer. We aimed to describe the factors associated with mortality, thrombosis recurrence, and bleeding complications in patients with gastric cancer who develop venous thromboembolism. We included 612 patients with gastric cancer and venous thromboembolism in the Registro Informatizado de la Enfermedad TromboEmbolica (RIETE) registry from 2001 to 2018. We used Cox proportional hazard ratios and a Fine-Gray model to define factors associated with outcomes. The overall mortality at 6 months was 44.4%. Factors associated with increased 6-month mortality included immobility (HR 1.8, 95% CI 1.3-2.4; p < 0.001), anemia (HR 1.4, 95% CI 1.1-1.8; p < 0.02), and leukocytosis (HR 1.8, 95% CI 1.4-2.3; p < 0.001). Recurrent thrombosis occurred in 6.5% of patients and major bleeding complications in 8.5% of the cohort. Male sex was the main factor associated with thrombosis recurrence (HR 2.1, 95% CI 1.1-4.0; p < 0.02) and hemoglobin below 10 g/dL (HR 1.6, 95% CI 1.05-2.50; p = 0.03) the main factor associated with bleeding. In conclusion, patients with gastric cancer who develop venous thrombosis have a very high likelihood of death. Low hemoglobin in this population is associated with poor outcomes.
Filiaciones:
Majmudar, K:
NorthShore Univ HealthSyst, Dept Med, Div Internal Med, 2650 Ridge Ave, Evanston, IL 60201 USA
Golemi, I:
NorthShore Univ HealthSyst, Dept Med, Div Internal Med, 2650 Ridge Ave, Evanston, IL 60201 USA
Tafur, A:
NorthShore Univ HealthSyst, Dept Med, Div Vasc Med, Evanston, IL 60201 USA
Del Toro, J:
Hosp Gen Univ Gregorio Maranon, Dept Internal Med, Madrid, Spain
Visona, A:
Osped Castelfranco Veneto, Dept Vasc Med, Castelfranco Veneto, Italy
Falga, C:
Hosp Mataro, Dept Internal Med, Barcelona, Spain
Sahuquillo, J:
Hosp Municipal Badalona, Dept Internal Med, Barcelona, Spain
:
Hosp Vega Baja Orihuela, Dept Internal Med, Alicante, Spain
Tufano, A:
Federico II Univ Hosp, Reg Reference Ctr Coagulat Disorders, Dept Clin Med & Surg, Naples, Italy
Weinberg, I:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02115 USA
Monreal, M:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Dept Internal Med, Barcelona, Spain
Open Access
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