Postnatal exposure to mercury and neuropsychological development among preschooler children.
Por:
Llop S, Murcia M, Amorós R, Julvez J, Santa-Marina L, Soler-Blasco R, Rebagliato M, Iñiguez C, Aguinagalde X, Iriarte G, Lopez-Espinosa MJ, Andiarena A, Gonzalez L, Vioque J, Sunyer J and Ballester F
Publicada:
13 mar 2020
Ahead of Print:
13 mar 2020
Resumen:
The objective of this study was to describe the postnatal exposure to Hg and to evaluate its association with neuropsychological development among preschool children. The study population are 4-5 years old children (n = 1252) participant in the Spanish INMA Project. Total Hg was measured in cord blood and in hair samples taken at 4 years of age (2008-2012). Neuropsychological development was assessed using the McCarthy Scales of Children's Abilities (MSCA). Information on covariates and possible confounders was obtained by questionnaires during pregnancy and childhood. Generalized additive and linear regression models were built in order to assess the relationship between MSCA scores and Hg exposure. We also evaluated the magnitude of the possible bias generated from measurement error in seafood intake estimate from questionnaire and Hg determination. The geometric mean of hair Hg was 0.98 µg/g [95% confidence interval (CI) 0.94, 1.03]. In the regression analysis, the association between Hg and the MSCA scores was positive for all the scales and statistically significant for the verbal (ß = 0.89; 95%CI 0.38, 1.39), memory (ß = 0.42; 95%CI 0.09, 0.76) and general cognitive scales (ß = 1.35; 95%CI 0.45, 2.25). However, these associations were clearly attenuated when we adjusted by the children's fish intake variables or when took into account theoretical scenarios of low precision in fish intake and Hg measurements. Hg levels in this Spanish population were high in comparison with other European countries; however, we did not observe adverse effects on child neuropsychological development associated with this postnatal exposure to Hg.
Filiaciones:
Llop S:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain.
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain.
Murcia M:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain
Amorós R:
School of Mathematics, University of Edinburgh, Peter Guthrie Tait Road, Edinburgh, EH9 3FD, UK
Julvez J:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain
Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Reus, Spain
Barcelona Institute for Global Health (ISGlobal), Dr. Aiguader 88, 08003, Barcelona, Spain
Municipal Institute of Medical Research, IMIM-Hospital del Mar, Dr. Aiguader 88, 08003, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Plaça de la Mercè 10-12, 08002, Barcelona, Spain
Santa-Marina L:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain
Health Department of Basque Government, Sub-directorate of Public Health of Gipuzkoa, 20013, San Sebastián, Spain
Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014, San Sebastián, Spain
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain
Department of Medicine, Universitat Jaume I, Avenida de Vicent Sos Baynat s/n, 12071, Castellón de la Plana, Spain
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain
Aguinagalde X:
Laboratorio de Salud Pública de Alava, Santiago 11, 01002, Vitoria Gasteiz, Spain
Iriarte G:
Laboratorio de Salud Pública de Alava, Santiago 11, 01002, Vitoria Gasteiz, Spain
Lopez-Espinosa MJ:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain
Nursing School, Universitat de València, C/Jaume Roig s/n, 46010, Valencia, Spain
Andiarena A:
Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014, San Sebastián, Spain
Faculty of Psychology, University of the Basque Country, Tolosa Hiribidea 70, 20018, San Sebastián, Spain
Gonzalez L:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain
:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain
Universidad Miguel Hernandez, Avenida de Alicante KM 87, 03550, Sant Joan d'Alacant, Spain
Sunyer J:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain
Barcelona Institute for Global Health (ISGlobal), Dr. Aiguader 88, 08003, Barcelona, Spain
Municipal Institute of Medical Research, IMIM-Hospital del Mar, Dr. Aiguader 88, 08003, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Plaça de la Mercè 10-12, 08002, Barcelona, Spain
Ballester F:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain
Nursing School, Universitat de València, C/Jaume Roig s/n, 46010, Valencia, Spain
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