Dysbiotic microbiota interactions in Crohn's disease.
Por:
Caparrós E, Wiest R, Scharl M, Rogler G, Gutiérrez Casbas A, Yilmaz B, Wawrzyniak M and Francés R
Publicada:
1 ene 2021
Resumen:
Crohn's disease (CD) is a major form of inflammatory bowel disease characterized by transmural inflammation along the alimentary tract. Changes in the microbial composition and reduction in species diversity are recognized as pivotal hallmarks in disease dynamics, challenging the gut barrier function and shaping a pathological immune response in genetically influenced subjects. The purpose of this review is to delve into the modification of the gut microbiota cluster network during CD progression and to discuss how this shift compromises the gut barrier integrity, granting the translocation of microbes and their products. We then complete the scope of the review by retracing gut microbiota dysbiosis interactions with the main pathophysiologic factors of CD, starting from the host's genetic background to the immune inflammatory and fibrotic processes, providing a standpoint on the lifestyle/exogenous factors and the potential benefits of targeting a specific gut microbiota.
Filiaciones:
:
Dpto Medicina Clínica, Universidad Miguel Hernández, San Juan De Alicante, Spain
Iis Isabial, Hospital General Universitario De Alicante, Alicante, Spain
Wiest R:
Department for Biomedical Research, Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland
Scharl M:
Department of Gastroenterology and Hepatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
Rogler G:
Department of Gastroenterology and Hepatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
:
Iis Isabial, Hospital General Universitario De Alicante, Alicante, Spain
CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain
Yilmaz B:
Department for Biomedical Research, Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland
Wawrzyniak M:
Department of Gastroenterology and Hepatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
:
Dpto Medicina Clínica, Universidad Miguel Hernández, San Juan De Alicante, Spain
Iis Isabial, Hospital General Universitario De Alicante, Alicante, Spain
CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain
Green Published, gold
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