Effect of metabolaid (R) on pre- and stage 1 hypertensive patients: A randomized controlled trial
Por:
Boix-Castejon, M, Herranz-Lopez, M, Olivares-Vicente, M, Campoy, P, Caturla, N, Jones, J, Zazo, J, Roche, E and Micol, V
Publicada:
1 sep 2021
Ahead of Print:
1 jul 2021
Resumen:
Many patients with stage 1 hypertension have difficulties to achieve lifestyle changes to avoid the progression of the disease. The use of natural alternatives with demonstrated blood pressure-regulating properties is instrumental at this stage, avoiding the side effects found in some pharmaceutical drugs. In this context, previous studies have indicated the possibility that a botanical nutraceutical product based on the combination of Lippia citriodora and Hibiscus sabdariffa extracts has hypotensive properties in overweight and obese individuals. Therefore, we aimed to evaluate the antihypertensive properties of this dietary supplement, as well as the effect on anthropometric and circulating parameters in pre-hypertensive and early stage 1 hypertensive patients (n = 84). The nutraceutical product, rich in polyphenolic compounds, has been assessed in a 6-week randomized, double-blind, placebo-controlled trial with pre-hypertensive and early stage 1 hypertensive (non-medicated) individuals. Participants consumed early in the morning in fasting conditions 2 capsules/day containing each one 250 mg of the polyphenolic extracts. Anthropometric and blood parameters as well as punctual and continuous blood pressure monitoring were determined in placebo and experimental groups. As a result and compared to baseline values, volunteers showed a significant reduction of average daily systolic/diastolic blood pressure as well as in daytime diastolic/systolic, nighttime diastolic blood pressure and in % dipper. Intergroup analysis revealed that the consumption of the plant extract resulted in a significant reduction of body fat content (-1.26%; p < 0.05) and nocturnal systolic blood pressure (-16.60 mmHg; p < 0.05) as well as an improvement of the dipper status (3.18%; p < 0.01). In conclusion, these results suggest that the nutraceutical acts as a main regulator of the individual's blood pressure towards healthier values, and therefore may be useful for prehypertensive/pre-medicated individuals.
Filiaciones:
:
Univ Miguel Hernandez, Alicante Inst Hlth & Biomed Res, ISABIAL Fdn, Inst Bioengn, Alicante, Spain
Univ Miguel Hernandez, Alicante Inst Hlth & Biomed Res, ISABIAL Fdn, Dept Appl Biol Nutr, Alicante, Spain
Herranz-Lopez, M:
Miguel Hernandez Univ UMH, Inst Invest Desarrollo Innovac & Biotecnol Sanit, Alicante 03202, Spain
Olivares-Vicente, M:
Miguel Hernandez Univ UMH, Inst Invest Desarrollo Innovac & Biotecnol Sanit, Alicante 03202, Spain
Campoy, P:
Miguel Hernandez Univ UMH, Inst Invest Desarrollo Innovac & Biotecnol Sanit, Alicante 03202, Spain
Caturla, N:
Monteloeder SL, C Miguel Servet 16,Nave 17, Alicante 03203, Spain
Jones, J:
Monteloeder SL, C Miguel Servet 16,Nave 17, Alicante 03203, Spain
Zazo, J:
Raval Hlth Ctr, Alicante, Spain
:
Univ Miguel Hernandez, Alicante Inst Hlth & Biomed Res, ISABIAL Fdn, Inst Bioengn, Alicante, Spain
Univ Miguel Hernandez, Alicante Inst Hlth & Biomed Res, ISABIAL Fdn, Dept Appl Biol Nutr, Alicante, Spain
Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain
:
Miguel Hernandez Univ UMH, Inst Invest Desarrollo Innovac & Biotecnol Sanit, Alicante 03202, Spain
Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain
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