Do the Prostate-Specific Antigen (PSA) Tests That Are Ordered in Clinical Practice Adhere to the Pertinent Guidelines?
Por:
Bernal-Soriano, M, Parker, L, Lopez-Garrigos, M, Hernandez-Aguado, I, Gomez-Perez, L, Caballero-Romeu, J, Pastor-Valero, M, Garcia, N, Alfayate-Guerra, R and Lumbreras, B
Publicada:
1 jun 2021
Ahead of Print:
16 jun 2021
Resumen:
Scientific societies have provided guidelines to reduce PSA-specific harms. We studied the potential non-compliance of PSA testing with current guidelines in general practice. A cross-sectional study of a random sample of 1291 patients with a PSA test was performed between January and April 2018 in primary health care. Patients with a previous prostate cancer diagnosis or those who were being followed-up for previous high PSA values were excluded. Two independent researchers classified whether each test was potentially non-compliant with recommendations. We estimated frequencies of potentially non-compliant PSA determinations and calculated prevalence ratios (PR) to assess their relationship with possible explanatory variables. A total of 66% (95% CI: 62-69%) of PSA requests in asymptomatic patients were potentially non-compliant with the current guideline. This was associated with having a previous diagnosis of neoplasm (PR adjusted by age and life expectancy: 1.18; 95% CI: 1.02-1.37) as well as being a current consumer of tobacco, alcohol, or other drugs (PR: 0.80; 95% CI: 0.67-0.97). Real world data shows that patients are still frequently exposed to overdiagnosis risk with a PSA potentially non-compliant with recommendations. Patients diagnosed with another neoplasm or non-consumers of toxic substances were more exposed, probably due to increased contact with doctors or health-seeking behaviour.
Filiaciones:
:
Univ Miguel Hernandez Elche, Dept Publ Hlth, Alicante 03550, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Parker, L:
Univ Miguel Hernandez Elche, Dept Publ Hlth, Alicante 03550, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Univ Hosp San Juan Alicante, Clin Lab Dept, Alicante 03550, Spain
Hernandez-Aguado, I:
Univ Miguel Hernandez Elche, Dept Publ Hlth, Alicante 03550, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
:
Univ Hosp San Juan Alicante, Urol Dept, Alicante 03550, Spain
Miguel Hernandez Univ Elche, Pathol & Surg Dept, Alicante 03550, Spain
:
Univ Gen Hosp Alicante, Dept Urol, Alicante 03010, Spain
Alicante Inst Hlth & Biomed Res ISABIAL, Alicante 03010, Spain
:
Univ Miguel Hernandez Elche, Dept Publ Hlth, Alicante 03550, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
:
Univ Gen Hosp Alicante, Dept Urol, Alicante 03010, Spain
:
Univ Gen Hosp Alicante, Clin Lab Dept, Alicante 03010, Spain
:
Univ Miguel Hernandez Elche, Dept Publ Hlth, Alicante 03550, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
gold, Green Published
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