Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection
Por:
Caballero-Garcia, A, Perez-Valdecantos, D, Guallar, P, Caballero-Castillo, A, Roche, E, Noriega, D and Cordova, A
Publicada:
1 oct 2021
Ahead of Print:
9 oct 2021
Resumen:
Background and Objectives: Vitamin D, in addition to its effect on mineral homeostasis, plays a key role in muscle metabolism. Vitamin D supplementation is involved in muscle recovery after damage as a consequence of either pathology or after high-intensity exercise. In this context, the aim of this study was to analyze the effect of vitamin D on muscle fitness in elderly patients in the recovery phase after SARS-CoV-2 (COVID-19) infection.
Materials and Methods: This pilot study was conducted at the Soria Norte Health Center. The study consisted of a double-blind trial with two groups of men (placebo and vitamin D-supplemented) (n = 15/group). Treatment with vitamin D (cholecalciferol: 2000 IU/day) and placebo was carried out for 6 weeks. Circulating hematological and biochemical parameters (total protein, glucose, vitamin D, urea, uric acid, aspartate aminotransferase/glutamic-oxaloacetic transaminase, alanine aminotransferase/glutamic-pyruvic transaminase, creatine kinase, lactate dehydrogenase, aldolase, gamma-glutamyl transferase and myoglobin) and the hormones cortisol and testosterone were determined. As for respiratory function tests, FEV1 and respiratory flow were also studied. For physical fitness tests, the "six-minute walk test " (6MWT) was used.
Results: After vitamin D supplementation, we observed that serum creatine kinase levels returned to optimal values. This change suggests a protective role of vitamin D against muscle catabolism compared to placebo. In terms of physical test results, we observed only slight non-significant improvements, although patients reported feeling better.
Conclusions: Vitamin D supplementation produces decreases in indicators of muscle damage, which may ultimately contribute to improving the health status and quality of life of patients who have suffered from COVID-19, during the recovery process.
Filiaciones:
Caballero-Garcia, A:
Valladolid Univ, GIR Phys Exercise & Aging, Fac Hlth Sci, Dept Anat & Radiol, Univ Campus Los Pajaritos, Soria 42004, Spain
Perez-Valdecantos, D:
Valladolid Univ, GIR Phys Exercise & Aging, Fac Hlth Sci, Dept Biochem Mol Biol & Physiol, Univ Campus Los Pajaritos, Soria 42004, Spain
Guallar, P:
Soria Norte Hlth Ctr, SACYL, Avda Espolon S-N, Soria 42001, Spain
Caballero-Castillo, A:
Soria Norte Hlth Ctr, SACYL, Avda Espolon S-N, Soria 42001, Spain
:
Univ Miguel Hernandez, Inst Bioengn, Dept Appl Biol Nutr, Elche 03202, Spain
Alicante Inst Hlth & Biomed Res ISABIAL, Alicante 03010, Spain
Inst Salud Carlos III ISCIII, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain
Noriega, D:
Hosp Clin Univ Valladolid, Fac Med, Dept Surg Ophthalmol Otorhinolaryngol & Physiothe, Valladolid 47003, Spain
Cordova, A:
Valladolid Univ, GIR Phys Exercise & Aging, Fac Hlth Sci, Dept Biochem Mol Biol & Physiol, Univ Campus Los Pajaritos, Soria 42004, Spain
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