Successful Isavuconazole Salvage Therapy for a Cryptococcus deuterogattii (AFLP6/VGII) Disseminated Infection in a European Immunocompetent Patient
Por:
Cuetara, M, Ruiz-Capillas, J, Nunez-Valentin, M, Garcia, E, Garcia-Benayas, E, Rojo-Amigo, R, Rodriguez-Gallego, J, Hagen, F and Colom, M
Publicada:
1 ago 2021
Ahead of Print:
1 jun 2021
Resumen:
Members of the Cryptococcus gattii species complex are notorious causes of cryptococcosis as they often cause severe, life-threatening infections. Here we describe a case of a severe disseminated C. deuterogattii infection in a previously healthy patient who was initially treated with amphotericin B, 5-fluorocytosine and fluconazole, which led to a good neurological response, but the infection in the lungs remained unaltered and was not completely resolved until switching the antifungal therapy to isavuconazole. The infection was likely acquired during a one-month stay at the Azores Islands, Portugal. Environmental sampling did not yield any cryptococcal isolate; therefore, the source of this apparent autochthonous case could not be determined. Molecular typing showed that the cultured C. deuterogattii isolates were closely related to the Vancouver Island outbreak-genotype.
Filiaciones:
Cuetara, M:
Hosp Univ Severo Ochoa, Dept Microbiol, Avda Orellana S-N, Madrid 28914, Spain
Ruiz-Capillas, J:
Hosp Univ Severo Ochoa, Dept Med, Madrid, Spain
Nunez-Valentin, M:
Hosp Univ Severo Ochoa, Dept Radiol, Madrid, Spain
Garcia, E:
Hosp Univ Severo Ochoa, Dept Neurol, Madrid, Spain
Garcia-Benayas, E:
Hosp Univ Severo Ochoa, Dept Pharm, Madrid, Spain
Rojo-Amigo, R:
Hosp Maternoinfantil CHUAC, Dept Immunol, La Coruna, Spain
Rodriguez-Gallego, J:
Hosp Dr Negrin, Dept Immunol, Palmas De Gran Canaria, Spain
Hagen, F:
Westerdijk Fungal Biodivers Inst, Utrecht, Netherlands
Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands
Jining 1 Peoples Hosp, Med Mycol Lab, Jining, Shandong, Peoples R China
:
Univ Miguel Hernandez, Dept Plant Prod & Microbiol, Med Mycol Lab, Campus St Joan DAlacant, Alicante 03550, Spain
Inst Healthcare & Biomed Res Alicante, Isabial, Spain
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