Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex
Por:
Fernandez, E, Alfaro, A, Soto-Sanchez, C, Gonzalez-Lopez, P, Lozano, A, Pena, S, Grima, M, Rodil, A, Gomez, B, Chen, X, Roelfsema, P, Rolston, J, Davis, T and Normann, R
Publicada:
1 dic 2021
Resumen:
BACKGROUND. A long-held goal of vision therapy is to transfer information directly to the visual cortex of blind individuals, thereby restoring a rudimentary form of sight. However, no clinically available cortical visual prosthesis yet exists. METHODS. We implanted an intracortical microelectrode array consisting of 96 electrodes in the visual cortex of a 57-year-old person with complete blindness for a 6-month period. We measured thresholds and the characteristics of the visual percepts elicited by intracortical microstimulation. RESULTS. Implantation and subsequent explantation of intracortical microelectrodes were carried out without complications. The mean stimulation threshold for single electrodes was 66.8 +/- 36.5 IAA. We consistently obtained high-quality recordings from visually deprived neurons and the stimulation parameters remained stable over time. Simultaneous stimulation via multiple electrodes was associated with a significant reduction in thresholds (P < 0.001, ANOVA) and evoked discriminable phosphene percepts, allowing the blind participant to identify some letters and recognize object boundaries. CONCLUSIONS. Our results demonstrate the safety and efficacy of chronic intracortical microstimulation via a large number of electrodes in human visual cortex, showing its high potential for restoring functional vision in the blind. TRIAL REGISTRATION. ClinicalTrials.gov identifier NCT02983370.
Filiaciones:
:
Univ Miguel Hernandez, Bioengn Inst, Avda Univ S-N, Elche 03202, Spain
Univ Miguel Hernandez, Catedra Bidons Egara, Elche, Spain
CIBER Res Ctr Bioengn Biomat & Nanomed CIBER BBN, Madrid, Spain
Univ Utah, John Moran Eye Ctr & Biomed Engn, Salt Lake City, UT USA
:
Univ Miguel Hernandez, Bioengn Inst, Avda Univ S-N, Elche 03202, Spain
Univ Miguel Hernandez, Catedra Bidons Egara, Elche, Spain
CIBER Res Ctr Bioengn Biomat & Nanomed CIBER BBN, Madrid, Spain
Hosp Vega Baja, Serv Neurol, Orihuela, Spain
Soto-Sanchez, C:
Univ Miguel Hernandez, Bioengn Inst, Avda Univ S-N, Elche 03202, Spain
Univ Miguel Hernandez, Catedra Bidons Egara, Elche, Spain
CIBER Res Ctr Bioengn Biomat & Nanomed CIBER BBN, Madrid, Spain
:
Univ Miguel Hernandez, Bioengn Inst, Avda Univ S-N, Elche 03202, Spain
Univ Miguel Hernandez, Catedra Bidons Egara, Elche, Spain
Hosp Univ Alicante, Serv Neurocirugia, Alicante, Spain
Lozano, A:
Univ Miguel Hernandez, Bioengn Inst, Avda Univ S-N, Elche 03202, Spain
Univ Miguel Hernandez, Catedra Bidons Egara, Elche, Spain
Pena, S:
Univ Miguel Hernandez, Bioengn Inst, Avda Univ S-N, Elche 03202, Spain
Univ Miguel Hernandez, Catedra Bidons Egara, Elche, Spain
Grima, M:
Univ Miguel Hernandez, Bioengn Inst, Avda Univ S-N, Elche 03202, Spain
Univ Miguel Hernandez, Catedra Bidons Egara, Elche, Spain
Rodil, A:
Univ Miguel Hernandez, Bioengn Inst, Avda Univ S-N, Elche 03202, Spain
Univ Miguel Hernandez, Catedra Bidons Egara, Elche, Spain
Gomez, B:
Univ Miguel Hernandez, Bioengn Inst, Avda Univ S-N, Elche 03202, Spain
Univ Miguel Hernandez, Catedra Bidons Egara, Elche, Spain
Chen, X:
Netherlands Inst Neurosci, Dept Vis & Cognit, Amsterdam, Netherlands
Roelfsema, P:
Netherlands Inst Neurosci, Dept Vis & Cognit, Amsterdam, Netherlands
Vrije Univ Amsterdam, Ctr Neurogenom & Cognit Res, Dept Integrat Neurophysiol, Amsterdam, Netherlands
Acad Med Ctr, Dept Psychiat, Amsterdam, Netherlands
Rolston, J:
Univ Utah, Dept Neurosurg, Salt Lake City, UT USA
Univ Utah, Dept Biomed Engn, Salt Lake City, UT USA
Davis, T:
Univ Utah, John Moran Eye Ctr & Biomed Engn, Salt Lake City, UT USA
Univ Utah, Dept Neurosurg, Salt Lake City, UT USA
Univ Utah, Dept Biomed Engn, Salt Lake City, UT USA
Normann, R:
Univ Utah, John Moran Eye Ctr & Biomed Engn, Salt Lake City, UT USA
Univ Utah, Dept Neurosurg, Salt Lake City, UT USA
Univ Utah, Dept Biomed Engn, Salt Lake City, UT USA
Bronze, Green Submitted
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