Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19
Por:
Buxeda, A, Arias-Cabrales, C, Perez-Saez, M, Cacho, J, Pelegrin, S, Melilli, E, Aladren, M, Galeano, C, Lorenzo, I, Mazuecos, A, Saura, I, Franco, A, Ruiz-Fuentes, M, Sanchez-Camara, L, Siverio, O, Martin, M, Gonzalez-Garcia, E, Lopez, V, Martin-Moreno, P, Moina, I, Berrio, E, Moreso, F, Portoles, J, Santana-Estupinan, R, Zarraga, S, Canal, C, Sanchez-Alvarez, E, Pascual, J, Crespo, M and Spanish Soc Nephrology COVID-19 Gr
Publicada:
1 sep 2021
Ahead of Print:
6 jul 2021
Resumen:
Introduction: Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time to recovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acute kidney injury have been reported. Scant data are available on the use and safety of remdesivir in kidney transplant recipients.
Methods: We present a multicenter cohort study of 51 kidney transplant recipients with COVID-19 treated with remdesivir. Outcomes and safety were assessed.
Results: Mean age at diagnosis was 60 years, with a median time since kidney transplant of 4.5 years. Mean time since admission to remdesivir was 2 days. Twenty-eight patients (54.9%) required mechanical ventilation (19 noninvasive). Mortality was 18.9% and markedly higher if aged >= 65 years (45% vs. 3.2% in younger patients). Acute kidney injury was present in 27.7% of patients, but was diagnosed in 50% before treatment. No patients required remdesivir discontinuation because of adverse events. We did not find significant hepatoxicity or systemic symptoms resulting from the drug.
Conclusion: In our cohort of kidney transplant recipients, remdesivir was well tolerated and safe in renal and hepatic toxicity, but randomized trials are needed to assess its efficacy.
Filiaciones:
Buxeda, A:
Hosp Mar, Inst Mar Med Res IMIM, Dept Nephrol, Red Invest Renal RED inREN RD16 0009 0013, Barcelona, Spain
Arias-Cabrales, C:
Hosp Mar, Inst Mar Med Res IMIM, Dept Nephrol, Red Invest Renal RED inREN RD16 0009 0013, Barcelona, Spain
Perez-Saez, M:
Hosp Mar, Inst Mar Med Res IMIM, Dept Nephrol, Red Invest Renal RED inREN RD16 0009 0013, Barcelona, Spain
Cacho, J:
Hosp Badalona Germans Trias & Pujol, Dept Nephrol, Barcelona, Spain
Pelegrin, S:
Hosp Univ Son Espases, Dept Nephrol, Palma De Mallorca, Spain
Melilli, E:
Hosp Univ Bellvitge, Dept Nephrol, Barcelona, Spain
Aladren, M:
Hosp Univ Miguel Servet, Dept Nephrol, Zaragoza, Spain
Galeano, C:
Hosp Univ Ramon y Cajal, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Dept Nephrol, Madrid, Spain
Lorenzo, I:
Hosp Gen Albacete, Dept Nephrol, Albacete, Spain
Mazuecos, A:
Hosp Univ Puerta del Mar, Dept Nephrol, Cadiz, Spain
Saura, I:
Hosp Univ Virgen de la Arrixaca, Dept Nephrol, Murcia, Spain
:
Hosp Gen Univ Alicante, Dept Nephrol, Alicante, Spain
Ruiz-Fuentes, M:
Hosp Univ Virgen de las Nieves, Dept Nephrol, Granada, Spain
Sanchez-Camara, L:
Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IISGM, Dept Nephrol, Madrid, Spain
Siverio, O:
Hosp Univ Nuestra Senora de la Candelaria, Dept Nephrol, Tenerife, Spain
Martin, M:
Hosp Arnau Vilanova, Dept Nephrol, Lleida, Spain
Gonzalez-Garcia, E:
Hosp Univ La Paz, Dept Nephrol, Madrid, Spain
Lopez, V:
Hosp Reg Univ Malaga, Dept Nephrol, Malaga, Spain
Univ Malaga, Inst Invest Biomed Malaga IBIMA, Red Invest Renal REDinREN RD16 0009 0006, Malaga, Spain
Martin-Moreno, P:
Clin Univ Navarra, Navarra Inst Hlth Res IdiSNA, Dept Nephrol, Pamplona, Spain
Moina, I:
Hosp Univ Basurto, Dept Nephrol, Bilbao, Spain
Berrio, E:
Hosp Gen Univ Ciudad Real, Dept Nephrol, Ciudad Real, Spain
Moreso, F:
Hosp Univ Vall dHebron, Dept Nephrol, Barcelona, Spain
Portoles, J:
Hosp Univ Puerta de Hierro, Dept Nephrol, Madrid, Spain
Santana-Estupinan, R:
Hosp Univ Gran Canaria Doctor Negrin, Dept Nephrol, Las Palmas Gran Canaria, Spain
Zarraga, S:
Hosp Univ Cruces, Dept Nephrol, Bilbao, Spain
Canal, C:
Fundacio Puigvert, Dept Nephrol, Barcelona, Spain
Sanchez-Alvarez, E:
Hosp Cabuenes, Dept Nephrol, Gijon, Spain
Pascual, J:
Hosp Mar, Inst Mar Med Res IMIM, Dept Nephrol, Red Invest Renal RED inREN RD16 0009 0013, Barcelona, Spain
Crespo, M:
Hosp Mar, Inst Mar Med Res IMIM, Dept Nephrol, Red Invest Renal RED inREN RD16 0009 0013, Barcelona, Spain
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