Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in Peru
Por:
Ramos-Rincon, J, Ortiz-Martinez, S, Vasquez-Chasnamote, M, de-Miguel-Balsa, E, Gamboa-Paredes, O, Talledo-Albujar, M, Lopez-Campana, G, Celis-Salinas, J, Prieto-Perez, L, Gorgolas-Hernandez, M and Casapia-Morales, M
Publicada:
1 mar 2021
Ahead of Print:
25 feb 2021
Resumen:
Background. Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. The infection is endemic in some areas of Peru, but its prevalence in the Peruvian Amazon is not well established. We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. Moreover, we performed a systematic literature review and meta-analysis of the seroprevalence of HTLV infection in Peru. (2) Methods. This is a prospective cross-sectional study involving pregnant women attending health centers in the city of Iquitos, Peru, in May and June 2019. The presence of antibodies against HTLV-1 was assessed using ELISA (HTLV I + II ELISA recombinant v.4.0, Wiener lab, Rosario, Argentina). Positive cases were confirmed by Western Blot and HTLV-1 proviral load. (3) Results. The study included 300 pregnant women with a mean age of 26 years (standard deviation [SD] 6.4). Five patients were diagnosed with HTLV-1 infection (prevalence 1.7%, 95% confidence interval (CI) 0.7% to 3.8%). Pregnant women with HTLV-1 infection were discretely younger (mean age 22.6 [SD 22.6] vs. 26.8 [SD 6.3]; p = 0.128). None of the five women had been transfused, and all were asymptomatic. Two (40%) also had a positive serology for Strongyloides, but larvae were not detected in any of the parasitological stool studies. The systematic review component identified 40 studies, which showed that the prevalence of HTLV infection in the general population was 2.9% (95% CI 1.2% to 5.3%) and in women of childbearing age, 2.5% (95% CI 1.2% to 4.0%). (4) Conclusion. The prevalence of HTLV-1 in the Peruvian Amazon basin is about 1.7%, indicating an endemic presence. Screening for HTLV-1 in prenatal care is warranted.
Filiaciones:
:
Miguel Hernandez Univ Elche, Clin Med Dept, Alicante 03010, Spain
Gen Univ Hosp Alicante, Alicante 03010, Spain
Ortiz-Martinez, S:
Hlth Serv Castilla La Mancha, Med Practice El Ballestero, Albacete 02614, Spain
Vasquez-Chasnamote, M:
Peruvian Amazon Natl Univ, Nat Resources Res Ctr, Iquitos 16001, Peru
:
Miguel Hernandez Univ, Clin Med Dept, Alicante 03002, Spain
Gen Univ Hosp Elche, Alicante 03002, Spain
Gamboa-Paredes, O:
Amazon Rainforest Civil Assoc, Med Dept, Iquitos 16001, Peru
Talledo-Albujar, M:
Peruvian Univ Cayetano Heredia, Inst Trop Med Alexander von Humboldt, Virol Unit, Lima 15102, Peru
Lopez-Campana, G:
Peruvian Univ Cayetano Heredia, Inst Trop Med Alexander von Humboldt, Virol Unit, Lima 15102, Peru
Celis-Salinas, J:
Reg Hosp Loreto, Infect Dis & Trop Med Serv, Iquitos 1600, Peru
Natl Univ Peruvian Amazon, Iquitos 1600, Peru
Prieto-Perez, L:
Univ Hosp Fdn Jimenez Diaz, Infect Dis Div, Madrid 28040, Spain
Autonomous Univ Madrid, Madrid 28040, Spain
Gorgolas-Hernandez, M:
Univ Hosp Fdn Jimenez Diaz, Infect Dis Div, Madrid 28040, Spain
Autonomous Univ Madrid, Madrid 28040, Spain
Casapia-Morales, M:
Amazon Rainforest Civil Assoc, Med Dept, Iquitos 16001, Peru
Reg Hosp Loreto, Infect Dis & Trop Med Serv, Iquitos 16001, Peru
Natl Univ Peruvian Amazon, Iquitos 16001, Peru
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