Effect of Sex in Systemic Psoriasis Therapy: Differences in Prescription, Effectiveness and Safety in the BIOBADADERM Prospective Cohort
Por:
Hernandez-Fernandez, C, Carretero, G, Rivera, R, Ferrandiz, C, Dauden, E, De la Cueva, P, Belinchon, I, Gomez-Garcia, F, Herrera-Acosta, E, Ruiz-Genao, D, Ferran, M, Alsina, M, Baniandres-Rodriguez, O, Sanchez-Carazo, J, Botella-Estrada, R, Sahuquillo-Torralba, A, Rodriguez, L, Vilar-Alejo, J, Garcia-Donoso, C, Carrascosa, J, Llamas-Velasco, M, Herrera-Ceballos, E, Lopez-Estebaranz, J, Pujol-Marco, C, Descalzo, M, Garcia-Doval, I and BIOBADADERM Study Grp
Publicada:
1 ene 2021
Resumen:
The effect of sex on systemic therapy for psoriasis has not been well studied. The aim of this study was to analyse a large multicentre Spanish cohort of 2,881 patients with psoriasis (58.3% males), followed from January 2008 to November 2018, to determine whether sex influences prescription, effectiveness of therapy, and the risk of adverse events. The results show that women are more likely than men to be prescribed biologics. There were no differences between men and women in effectiveness of therapy, measured in terms of drug survival. Women were more likely to develop adverse events, but the difference in risk was small and does not justify different management. Study limitations include residual confounding and the use of drug survival as a proxy for effectiveness.
Filiaciones:
Hernandez-Fernandez, C:
Hosp Univ Gran Canaria Dr Negrin, Dept Dermatol, Las Palmas Gran Canaria, Spain
Carretero, G:
Hosp Univ Gran Canaria Dr Negrin, Dept Dermatol, Las Palmas Gran Canaria, Spain
Rivera, R:
Hosp Univ 12 Octubre, Dept Dermatol, Madrid, Spain
Ferrandiz, C:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Dauden, E:
Hosp Univ La Princesa, Inst Invest Sanitaria La Princesa IIS IP, Madrid, Spain
De la Cueva, P:
Hosp Univ Infanta Leonor, Madrid, Spain
:
Hosp Gen Univ Alicante, Alicante, Spain
Gomez-Garcia, F:
Hosp Univ Reina Sofia, Cordoba, Spain
Herrera-Acosta, E:
Hosp Univ Virgen Victoria, Malaga, Spain
Ruiz-Genao, D:
Hosp Univ Fdn Alcorcon, Madrid, Spain
Ferran, M:
Hosp del Mar, Parc Salut Mar, Barcelona, Spain
Alsina, M:
UB, Hosp Clin Barcelona, Barcelona, Spain
Baniandres-Rodriguez, O:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Sanchez-Carazo, J:
Hosp Gen Univ Valencia, Valencia, Spain
Botella-Estrada, R:
Hosp Univ & Politecn La Fe, Inst Invest Sanitaria La Fe IIS La Fe, Valencia, Spain
Sahuquillo-Torralba, A:
Hosp Univ & Politecn La Fe, Inst Invest Sanitaria La Fe IIS La Fe, Valencia, Spain
Rodriguez, L:
Hosp Virgen Rocio, Seville, Spain
Vilar-Alejo, J:
Hosp Univ Gran Canaria Dr Negrin, Dept Dermatol, Las Palmas Gran Canaria, Spain
Garcia-Donoso, C:
Hosp Univ 12 Octubre, Dept Dermatol, Madrid, Spain
Carrascosa, J:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Llamas-Velasco, M:
Hosp Univ La Princesa, Inst Invest Sanitaria La Princesa IIS IP, Madrid, Spain
Herrera-Ceballos, E:
Hosp Univ Virgen Victoria, Malaga, Spain
Lopez-Estebaranz, J:
Hosp Univ Fdn Alcorcon, Madrid, Spain
Pujol-Marco, C:
Hosp Univ & Politecn La Fe, Inst Invest Sanitaria La Fe IIS La Fe, Valencia, Spain
Descalzo, M:
Complexo Hosp Univ Vigo, Vigo, Spain
Garcia-Doval, I:
Complexo Hosp Univ Vigo, Vigo, Spain
Fdn Piel Sana AEDV, Res Unit, Madrid, Spain
gold
|