An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens
Por:
Sobas, M, Montesinos, P, Boluda, B, Bernal, T, Vellenga, E, Nomdedeu, J, Gonzalez-Campos, J, Chillon, M, Holowiecka, A, Esteve, J, Bergua, J, Gonzalez-Sanmiguel, J, Gil-Cortes, C, Tormo, M, Salamero, O, Manso, F, Fernandez, I, de la Serna, J, Moreno, M, Perez-Encinas, M, Krsnik, I, Ribera, J, Escoda, L, Lowenberg, B, Sanz, M, de Heredia, J, Hernandez, J, Arias, J, Ramos, F, Roman, A, Negri, S, Rayon, C, Fernandez-Calvo, F, Diaz-Mediavilla, J, Gil, C, Olave, M, Amutio, E, Pedro, C, Gorosquieta, A, Viguria, M, Zudaire, M, Molero, T, Sayas, M, Guardia, R, Esquembre, C, Garcia, R, Alcala, A, Lopez, J, Rubio, V, Amigo, M, Linares, M, San Miguel, J, Coruna, A, Deben, G, de la Camara, R, Molines, A, Loureiro, C, Allegue, M, Amador, L, Marti, J, Madero, L, Lassaletta, A, Cabezudo, M, Garcia-Larana, J, Rojas, R, Ortega, F, Penarrubia, M, Puente, F, Lopez-Ibor, B, Brunet, S, Ibanez, J, Sanchez, P, Novo, A, Guinea, J, Montero, A, Gonzalez, M, Martin, G, Martinez, J, Verdeguer, A, Garcia, P, Conde, E, Garcia, J, Capote, F, Bueno, J, Bastida, P, Rubio, A, Fuster, J, Gonzalez, J, Perez, I, Molina, J, Mateos, M, Ardaiz, M, Rodriguez-calvillo, M, Poderos, C, Arnan, M, Duarte, R, Diaz-Morfa, M, Martin-Chacon, E, Calvo-Villas, J, Garcia-Belmonte, D, Hernandez-Maraver, D, Ossenkoppele, G, van der Lelie, J, Sonneveld, P, Zijlmans, M, Maertens, J, de Valk, B, Wijermans, P, de Groot, M, Schouten, H, Biesma, D, van Marwijk, M, de Lisa, E, Golos, A, Ejduk, A, Armatys, A, Zarzycka, E, Knopinska, W, Miskiewicz, W, Jastrzab, B, Pluta, A, Paluszewska, M, Podhorecka, M, Gromek, T, Jakubas, B, Majcherek, M, Skret, A, Watek, M, Charlinski, G, Calbecka, M, Becht, R, Gadomska, A, Rzenno, E, Piszcz, J, Grosicki, S, Palmer, L, Ciarlo, S, Bezares, F, Rojas, F, Longoni, H, Gelemur, M, Fazio, P, Canepa, C, Saba, S, Balladares, G, Negri, P, Giunta, M, Milone, J, Lafalse, D, Sossa, C, Jaramillo, F, Mayer, J, Protivankova, M, Scwarz, J, PETHEMA Cooperative Grp, HOVON Cooperative Grp, PALG Cooperative Grp and GATLA Cooperative Grp
Publicada:
21 mar 2019
Resumen:
Out of 956, there were 95 (10%) CD56+ APL patients treated with PETHEMA ATRA and chemotherapy. CD56+ expression was associated with high WBC, BCR3 isoform, and co-expression of CD2, CD34, CD7, HLA-DR, CD15, and CD117 antigens. CD56+ vs CD56- APL presented higher induction death rate (16% vs 8%, p = .02) and 5-years cumulative incidence of relapse (33% versus 10%, p = .006), irrespectively of the Sanz score (low-risk 47% versus 5%, p < .001; intermediate 23% versus 7%, p < .001; and high-risk 42% versus 21%, p = .007). In the multivariate analysis, CD56 + (p < .0001), higher relapse-risk score (p = .001), and male gender (p = .05) retained the independent predictive value. CD56+ APL also showed a greater risk of CNS relapse (6% versus 1%, p < .001) and lower 5-year OS (75% versus 83%, p = .003). The AIDA-based LPA2012 trial, with an intensified consolidation schedule for CD56+ APL, will elucidate whether an intensified consolidation schedule could mitigate the relapse rate in this setting.
Filiaciones:
Sobas, M:
Wroclaw Med Univ, Dept Haematol Blood Neoplasms & Bone Marrow Trans, Pasteura 4, PL-50367 Wroclaw, Poland
Montesinos, P:
Univ Hosp La Fe, Dept Med, Valencia, Spain
Carlos III Inst, CIBERONC, Madrid, Spain
Hosp Univ La Fe, Valencia, Spain
Boluda, B:
Univ Hosp La Fe, Dept Med, Valencia, Spain
Bernal, T:
Cent Univ Hosp Asturias, Oviedo, Spain
Vellenga, E:
Univ Hosp, Groningen, Netherlands
Univ Med Ctr Groningen, Groningen, Netherlands
Nomdedeu, J:
Univ Autonoma Barcelona, Univ Hosp Santa Creu & St Paul, Hosp Holy Cross & St Paul, Barcelona, Spain
Gonzalez-Campos, J:
Univ Hosp Virgen Rocio, Seville, Spain
Chillon, M:
Carlos III Inst, CIBERONC, Madrid, Spain
Univ Hosp Salamanca, Salamanca, Spain
Holowiecka, A:
Silesian Med Univ, Katowice, Poland
Esteve, J:
Hosp Clin Barcelona, Barcelona, Spain
Bergua, J:
Hosp San Pedro Alcantara, Caceres, Spain
Gonzalez-Sanmiguel, J:
Insular Univ Hosp Gran Canaria, Las Palmas Gran Canaria, Spain
:
Gen Hosp, Alicante, Spain
Tormo, M:
Univ Hosp, Valencia, Spain
Hosp Clin Univ, Valencia, Spain
Salamero, O:
Univ Hosp Vall dHebron, Barcelona, Spain
Manso, F:
Gen Hosp, Albacete, Spain
Hosp Gen Albacete, Albacete, Spain
Fernandez, I:
Fundaleu, Buenos Aires, DF, Argentina
de la Serna, J:
Hosp 12 Octube, Madrid, Spain
Hosp 12 Octubre, Madrid, Spain
Moreno, M:
Univ Hosp Virgen Victoria, Malaga, Spain
Perez-Encinas, M:
Univ Hosp Santiago De Compostela, Santiago De Compostela, Spain
Hosp Clin Univ, Santiago De Compostela, Spain
Krsnik, I:
Hosp Puerta Hierro, Madrid, Spain
Hosp Univ Puerta Hierro, Madrid, Spain
Ribera, J:
Univ Hosp Germans Trias & Pujol, ICO, Badalona, Spain
Jose Carreras Res Inst, Badalona, Spain
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Escoda, L:
Hosp Joan 23, Tarragona, Spain
Lowenberg, B:
Erasmus Univ, Med Ctr, Rotterdam, Netherlands
Sanz, M:
Univ Hosp La Fe, Dept Med, Valencia, Spain
Carlos III Inst, CIBERONC, Madrid, Spain
Hosp Univ La Fe, Valencia, Spain
de Heredia, J:
Basurtuko Ospitalea, Programa Espanol Tratamiento Hemopatias Malignas, PETHEMA, Bilbao, Spain
Hernandez, J:
Complejo Hosp Segovia, Lugo, Spain
Hosp Fuenlabrada, Fuenlabrada, Spain
Arias, J:
Complexo Hosp Xeral Calde, Lugo, Spain
Ramos, F:
Hosp Univ, Leon, Spain
Roman, A:
Fdn Jimenez Diaz, Madrid, Spain
Negri, S:
Hosp Carlos Haya, Malaga, Spain
Rayon, C:
Hosp Cent Asturias, Oviedo, Spain
Fernandez-Calvo, F:
Hosp Clin Valladolid, Madrid, Spain
Diaz-Mediavilla, J:
Hosp Clin San Carlos, Madrid, Spain
Gil, C:
Hosp Clin San Carlos H Infantil, Madrid, Spain
Olave, M:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Amutio, E:
Hosp Cruces, Baracaldo, Spain
Pedro, C:
Hosp del Mar, Barcelona, Spain
Gorosquieta, A:
Hosp Navarra, Pamplona, Spain
Viguria, M:
Hosp Navarra, Pamplona, Spain
Zudaire, M:
Hosp Navarra, Pamplona, Spain
Molero, T:
Hosp Dr Negrin, Las Palmas Gran Canaria, Spain
Sayas, M:
Hosp Dr Peset, Valencia, Spain
Guardia, R:
Hosp Dr Trueta, Girona, Spain
Esquembre, C:
Hosp Gen Albacete Oncol Pediat, Albacete, Spain
Garcia, R:
Hosp Gen Castellon, Castellon de La Plana, Spain
Alcala, A:
Hosp Gen Especialidades Ciudad Jaen, Jaen, Spain
Lopez, J:
Hosp Gen Especialidades Ciudad Jaen, Jaen, Spain
Rubio, V:
Hosp Gen Jerez Frontera, Andalucia, Spain
Amigo, M:
Hosp Gen Murcia, Murcia, Spain
Linares, M:
Hosp Gen Valencia, Valencia, Spain
San Miguel, J:
Hosp Insular Las Palmas, La Coruna, Spain
Deben, G:
Hosp Juan Canalejo, La Coruna, Spain
de la Camara, R:
Hosp La Princesa, Madrid, Spain
Molines, A:
Hosp Maternoinfantil Las Palmas, Vigo, Spain
Loureiro, C:
Hosp Meixoeiro, Vigo, Spain
Allegue, M:
Hosp Montecelo, Pontevedra, Spain
Amador, L:
Hosp Montecelo, Pontevedra, Spain
Marti, J:
Hosp Mutua Terrasa, Madrid, Spain
Madero, L:
Hosp Nino Jesus, Madrid, Spain
Lassaletta, A:
Hosp Nino Jesus, Madrid, Spain
Cabezudo, M:
Hosp Ntra Sra Sonsoles, Avila, Spain
Garcia-Larana, J:
Hosp Ramon & Cajal, Madrid, Spain
Rojas, R:
Hosp Reina Sofia, Cordoba, Spain
Ortega, F:
Hosp Rio Carrion, Palencia, Spain
Penarrubia, M:
Hosp Rio Hortega, Valladolid, Spain
Puente, F:
Hosp San Jorge, Huesca, Spain
Lopez-Ibor, B:
Hosp San Rafael, Madrid, Spain
Brunet, S:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Ibanez, J:
Hosp Santa Maria Rosell, Cartagena, Spain
Sanchez, P:
Hosp Severo Ochoa, Leganes, Spain
Novo, A:
Hosp Son Dureta, Palma De Mallorca, Spain
Guinea, J:
Hosp Txagorritxu, Vitoria, Spain
Montero, A:
Hosp Univ Aire, Madrid, Spain
Gonzalez, M:
Hosp Univ Salamanca, Salamanca, Spain
Martin, G:
Hosp Univ La Fe, Valencia, Spain
Martinez, J:
Hosp Univ La Fe, Valencia, Spain
Verdeguer, A:
Hosp Univ La Fe, Hosp Infantil, Valencia, Spain
Garcia, P:
Hosp Univ La Fe, Hosp Infantil, Madrid, Spain
Conde, E:
Hosp Univ Marques Valdecilla, Santander, Spain
Garcia, J:
Hosp Univ Principe Asturias, Alcala De Henares, Spain
Capote, F:
Hosp Univ Puerta Mar, Cadiz, Spain
Bueno, J:
Hosp Univ Vall dHebron, Barcelona, Spain
Bastida, P:
Hosp Univ Materno Infantil Vall DHebron, Barcelona, Spain
Rubio, A:
Hosp Univ Virgen Arrixaca, Murcia, Spain
Fuster, J:
Hosp Univ Virgen Arrixaca Pediat, Murcia, Spain
Gonzalez, J:
Hosp Univ Virgen Rocio, Seville, Spain
Perez, I:
Hosp Univ Virgen Victoria, Malaga, Spain
Molina, J:
Hosp Virgen Camino Infantil, Pamplona, Spain
Mateos, M:
Hosp Virgen Camino Adultos, Pamplona, Spain
Ardaiz, M:
Hosp Virgen Camino Adultos, Pamplona, Spain
Rodriguez-calvillo, M:
Clin San Miguel, Pamplona, Spain
Poderos, C:
Hosp Xeral Cies, Vigo, Spain
Arnan, M:
Inst Catala Oncol, Lhospitalet De Llobregat, Spain
Duarte, R:
Inst Catala Oncol, Lhospitalet De Llobregat, Spain
Diaz-Morfa, M:
Hosp Gen Guadalajara, Guadalajara, Spain
Martin-Chacon, E:
Hosp Juan Ramon Jimenez, Huelva, Spain
Calvo-Villas, J:
Hosp Doctor Jose Molina Orosa, Lanzarote, Spain
Garcia-Belmonte, D:
Hosp Madrid Norte Sanchinarro, Madrid, Spain
Hernandez-Maraver, D:
Hosp U La Paz, Madrid, Spain
Ossenkoppele, G:
VU Med Ctr Amsterdam, Dutch Belgian Hematooncol Cooperat Grp, HOVON, Amsterdam, Netherlands
van der Lelie, J:
Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands
Sonneveld, P:
Erasmus Univ, Med Ctr, Rotterdam, Netherlands
Zijlmans, M:
Erasmus Univ, Med Ctr, Rotterdam, Netherlands
Maertens, J:
Gasthuisberg Hosp, Leuven, Belgium
de Valk, B:
OLVG Hosp, Amsterdam, Netherlands
Wijermans, P:
Den Haag Hosp, Leyenburg, Netherlands
de Groot, M:
Med Spectrum Twente Hosp, Enschede, Netherlands
Schouten, H:
Acad Hosp Maastricht, Maastricht, Netherlands
Biesma, D:
St Antonius Hosp, Nieuwegein, Netherlands
van Marwijk, M:
Sophia Hosp, Zwolle, Netherlands
de Lisa, E:
Hosp Maciel, Montevideo, Uruguay
Golos, A:
PALG, Inst Hematol, Warsaw, Poland
Ejduk, A:
PALG, Inst Hematol, Warsaw, Poland
Armatys, A:
Silesian Med Univ, Katowice, Poland
Zarzycka, E:
Med Univ Sch, Gdansk, Poland
Knopinska, W:
Med Univ Sch, Gdansk, Poland
Miskiewicz, W:
Wroclaw Med Univ, Wroclaw, Poland
Jastrzab, B:
Wroclaw Med Univ, Wroclaw, Poland
Pluta, A:
Med Univ, Lodz, Poland
Paluszewska, M:
Med Univ, Warsaw, Poland
Podhorecka, M:
Med Univ, Lublin, Poland
Gromek, T:
Med Univ, Lublin, Poland
Jakubas, B:
Jagiellonian Univ, Coll Med, Krakow, Poland
Majcherek, M:
Poznan Med Univ, Poznan, Poland
Skret, A:
City Hosp, Rzeszow, Poland
Watek, M:
Ctr Oncol, Kielce, Poland
Charlinski, G:
City Hosp, Torun, Poland
Calbecka, M:
City Hosp, Torun, Poland
Becht, R:
Univ Hosp, Szczecin, Poland
Gadomska, A:
City Hosp, Bydgoszcz, Poland
Rzenno, E:
City Hosp, Krakow, Poland
Piszcz, J:
Med Univ, Bialystok, Poland
Grosicki, S:
City Hosp, Chorzow, Poland
Palmer, L:
Complejo Med Policia Fed, GATLA, La Plata, Buenos Aires, Argentina
Hosp Tortosa, Vitoria, Spain
Ciarlo, S:
Hosp Clemente Alvarez, Rosario, Santa Fe, Argentina
Bezares, F:
Hosp Clemente Alvarez, Rosario, Santa Fe, Argentina
Rojas, F:
Hosp Clin Buenos Aires, Buenos Aires, DF, Argentina
Longoni, H:
Hosp Clin Buenos Aires, Buenos Aires, DF, Argentina
Gelemur, M:
Hosp Gen San Martin, La Plata, Buenos Aires, Argentina
Fazio, P:
Hosp Gen San Martin, La Plata, Buenos Aires, Argentina
Canepa, C:
Hosp Rossi, La Plata, Buenos Aires, Argentina
Saba, S:
Hosp Rossi, La Plata, Buenos Aires, Argentina
Balladares, G:
Hosp Rossi, La Plata, Buenos Aires, Argentina
Negri, P:
Hosp San Martin Parana, Entre Rios, Argentina
Giunta, M:
Inst Privado Hematol, Parana, Argentina
Milone, J:
Inst Trasplante Medula Osea, La Plata, Buenos Aires, Argentina
Lafalse, D:
Hosp Tornu, Buenos Aires, DF, Argentina
Sossa, C:
Inst FOSCAL, Bucaramanga, Colombia
Jaramillo, F:
Fdn Valle Lili, Cali, Colombia
Mayer, J:
Fac Hosp, Brno, Czech Republic
Protivankova, M:
Fac Hosp, Brno, Czech Republic
Scwarz, J:
IHBT, Prague, Czech Republic
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