Polysubstance Use Patterns Among High Dose Benzodiazepine Users: A Latent Class Analysis and Differences Between Male and Female Use


Por: Zamboni, L, Portoghese, I, Congiu, A, Zandonai, T, Casari, R, Fusina, F, Bertoldi, A and Lugoboni, F

Publicada: 25 ene 2022 Ahead of Print: 25 ene 2022
Resumen:
Benzodiazepines (BZDs) represent one of the most widely used groups of pharmaceuticals, but if used for long periods of time they are associated with dependence and an increased risk of harmful effects. High-dose (HD) BZD dependence is a specific substance use disorder associated with a poor quality of life. It is especially important to pinpoint differences in HD BZD addict subgroups in order to tailor treatment to the individual's specific needs, also considering possible comorbidities with other substance use disorders. We conducted a study to evaluate HD BZD dependence (converted doses to diazepam equivalents, mg) in an Italian sample of 1,354 participants. We also investigated if and to which extent participants co-used other substances (alcohol, tobacco, cannabis/cannabinoids, cocaine, and heroin). We then performed latent class analysis (LCA) to identify the use patterns of these substances, finding three classes: participants in Class 1 (4.3% of the sample) had the highest probability of also using cocaine and alcohol (Polysubstance BZD users); Class 2 comprised subjects with the highest probability of being former heroin, cocaine, THC, and alcohol users (Former polysubstance BZD users); Class 3 represented mono-dependence BZD users (78.5% of the sample) and was the most prevalent among women, while young men were most prevalent in Class 1.The present study underlines different characteristics in HD BZD users both concerning other addictions and sex, and also highlights the need for a stricter control of BZD use, ranging from prescriptions to sales.

Filiaciones:
Zamboni, L:
 Integrated Univ, Dept Internal Med, Unit Addict Med, Policlin G B Rossi,Hosp Verona, Verona, Italy

 Univ Verona, Dept Neurosci, Verona, Italy

Portoghese, I:
 Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy

Congiu, A:
 Integrated Univ, Dept Internal Med, Unit Addict Med, Policlin G B Rossi,Hosp Verona, Verona, Italy

:
 Miguel Hernandez Univ, Dept Sport Sci, Sports Res Ctr, Elche, Spain

 Inst Hlth & Biomed Res Alicante ISABIAL, Neuropharmacol Pain & Funct Div NED, Alicante, Spain

Casari, R:
 Integrated Univ, Dept Internal Med, Unit Addict Med, Policlin G B Rossi,Hosp Verona, Verona, Italy

Fusina, F:
 Univ Padua, Padova Neurosci Ctr, Padua, Italy

 Univ Padua, Dept Gen Psychol, Padua, Italy

Bertoldi, A:
 Integrated Univ, Dept Internal Med, Unit Addict Med, Policlin G B Rossi,Hosp Verona, Verona, Italy

Lugoboni, F:
 Integrated Univ, Dept Internal Med, Unit Addict Med, Policlin G B Rossi,Hosp Verona, Verona, Italy
ISSN: 16640640





Frontiers in Psychiatry
Editorial
Frontiers Media S.A., AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND, Suiza
Tipo de documento: Article
Volumen: 13 Número:
Páginas: 811130-811130
WOS Id: 000752092700001
ID de PubMed: 35145442
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