Prenatal arsenic exposure, arsenic methylation efficiency, and neuropsychological development among preschool children in a Spanish birth cohort
Por:
Soler-Blasco, R, Murcia, M, Lozano, M, Sarzo, B, Esplugues, A, Riutort-Mayol, G, Vioque, J, Lertxundi, N, Santa Marina, L, Lertxundi, A, Irizar, A, Braeuer, S, Ballester, F and Llop, S
Publicada:
1 may 2022
Ahead of Print:
15 oct 2021
Resumen:
Background: Prenatal arsenic (As) exposure could negatively affect child neuropsychological development, but the current evidence is inconclusive.
Objectives: To explore the relationship between prenatal urinary total As (TAs) concentrations, the As species and the methylation efficiency, and child neuropsychological development in a Spanish birth cohort. We also studied the effect modification produced by sex and several nutrients and elements.
Materials and methods: Study subjects were 807 mother-child pairs participating in the INMA (Childhood and Environment) Project. Urinary TAs and its metabolites, monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), inorganic As (iAs) and arsenobetaine were measured in the first trimester of pregnancy. Methylation efficiency was determined through the percentages of the metabolites and using principal component analysis. Children's neuropsychological development was assessed at the age of 4-5 years using the McCarthy Scales of Children's Abilities (MSCA). Multivariable linear regression models were built to assess the association between TAs, the As species and the maternal methylation efficiency, and the neuropsychological scores. We explored effect modification by sex, iron status, maternal nutrients status (serum manganese and selenium, and urinary zinc), and maternal vitamins intake (folate, and vitamins B-12 and B-6).
Results: The geometric mean (95%CI) of Sigma(As) (sum of DMA, MMA and iAs) was 7.78 (7.41, 8.17) mu g/g creatinine. MMA concentrations were inversely associated with the scores for the general, verbal, quantitative, memory, executive function and working memory scales (i.e. beta [CI95%] = -1.37 [-2.33, -0.41] for the general scale). An inverse association between %MMA and the memory scores was found. Children whose mothers had lower manganese, zinc and ferritin concentrations obtained lower scores on several MSCA scales with decreasing As methylation efficiency.
Discussion: An inverse association was observed between MMA concentrations and children's neuropsychological development. Maternal levels of manganese, zinc and ferritin affected the association between As methylation efficiency and MSCA scores.
Filiaciones:
Soler-Blasco, R:
Univ Valencia, Univ Jaume I, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain
Murcia, M:
Univ Valencia, Univ Jaume I, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain
Generalitat Valenciana, Hlth Informat Syst Anal Serv, Conselleria Sanitat, Valencia, Spain
Lozano, M:
Univ Valencia, Univ Jaume I, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain
Univ Valencia, Prevent Med & Publ Hlth, Food Sci Toxicol & Forens Med Dept, Valencia, Spain
Sarzo, B:
Fdn Promot Hlth & Biomed Res Valencian Reg, FISABIO Publ Hlth, Valencia, Spain
Esplugues, A:
Univ Valencia, Univ Jaume I, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain
Univ Valencia, Dept Nursing, Valencia, Spain
Riutort-Mayol, G:
Fdn Promot Hlth & Biomed Res Valencian Reg, FISABIO Publ Hlth, Valencia, Spain
:
ISABIAL UMH, Alicante Inst Hlth & Biomed Res, Alicante, Spain
Lertxundi, N:
Biodonostia Hlth Res Inst, San Sebastian, Spain
Univ Basque Country, UPV EHU, Fac Psychol, San Sebastian, Spain
Santa Marina, L:
Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain
Biodonostia Hlth Res Inst, San Sebastian, Spain
Basque Govt, Publ Hlth Div Gipuzkoa, San Sebastian, Spain
Lertxundi, A:
Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain
Biodonostia Hlth Res Inst, San Sebastian, Spain
Univ Basque Country, UPV EHU, Dept Prevent Med & Publ Hlth, Leioa 48940, Spain
Irizar, A:
Biodonostia Hlth Res Inst, San Sebastian, Spain
Univ Basque Country, UPV EHU, Dept Prevent Med & Publ Hlth, Leioa 48940, Spain
Braeuer, S:
Karl Franzens Univ Graz, Inst Chem, Graz, Austria
Ballester, F:
Univ Valencia, Univ Jaume I, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain
Univ Valencia, Dept Nursing, Valencia, Spain
Llop, S:
Univ Valencia, Univ Jaume I, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain
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