Adenosquamous cancer of the pancreas: A multicenter retrospective study.
Por:
Ramia-Angel JM, Jaén-Torrejimeno I, Serrablo-Requejo A, Rodríguez-Laiz GP, López-Guerra D, Abadía-Forcén T, Alenda C, Serradilla-Martín M and Blanco-Fernández G
Publicada:
1 ago 2022
Ahead of Print:
21 dic 2021
Resumen:
INTRODUCTION: Adenosquamous cancer of the pancreas (ASCP) is an aggressive, infrequent subtype of pancreatic cancer that combines a glandular and squamous component and is associated with poor survival. METHODS: Multicenter retrospective observational study carried out at three Spanish hospitals. The study period was: January 2010-August 2020. A descriptive analysis of the data was performed, as well as an analysis of global and disease-free survival using the Kaplan-Meier statistic. RESULTS: Of a total of 668 pancreatic cancers treated surgically, twelve were ASCP (1.8%). Patient mean age was 69.2±7.4 years. Male/female ratio was 1:1. The main symptom was jaundice (seven patients). Correct preoperative diagnosis was obtained in only two patients. Nine pancreatoduodenectomies and three distal pancreatosplenectomies were performed. 25% had major complications. Mean tumor size was 48.6±19.4mm. Nine patients received adjuvant chemotherapy. Median survival time was 5.9 months, and median disease-free survival was 4.6 months. 90% of patients presented recurrence. Ten of the twelve patients in the study (83.3%) died, with disease progression being the cause in eight. Of the two surviving patients, one is disease-free and the other has liver metastases. CONCLUSION: ASCP is a very rare pancreatic tumor with aggressive behavior. It is rarely diagnosed preoperatively. The best treatment, if feasible, is surgery followed by the standard chemotherapy regimens for pancreatic adenocarcinoma.
Filiaciones:
:
Servicio de Cirugía General, Hospital General Universitario, Alicante, Spain
ISABIAL: Instituto de Investigación Sanitaria y Biomédica, Alicante, Spain
Jaén-Torrejimeno I:
Servicio de Cirugía General, Complejo Hospitalario de Badajoz, Badajoz, Spain
Serrablo-Requejo A:
Servicio de Cirugía General, Hospital Universitario Miguel Servet, Zaragoza, Spain
Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain
:
Servicio de Cirugía General, Hospital General Universitario, Alicante, Spain
ISABIAL: Instituto de Investigación Sanitaria y Biomédica, Alicante, Spain
López-Guerra D:
Servicio de Cirugía General, Complejo Hospitalario de Badajoz, Badajoz, Spain
Abadía-Forcén T:
Servicio de Cirugía General, Hospital Universitario Miguel Servet, Zaragoza, Spain
:
Servicio de Cirugía General, Hospital General Universitario, Alicante, Spain
Servicio de Anatomía Patológica, Hospital General Universitario, Alicante, Spain
Serradilla-Martín M:
Servicio de Cirugía General, Hospital Universitario Miguel Servet, Zaragoza, Spain
Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain
Blanco-Fernández G:
Servicio de Cirugía General, Complejo Hospitalario de Badajoz, Badajoz, Spain
Universidad de Extremadura, Badajoz, Spain
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