Optical Assessment of Nociceptive TRP Channel Function at the Peripheral Nerve Terminal
Por:
Aleixandre-Carrera, F, Engelmayer, N, Ares-Suarez, D, Acosta, M, Belmonte, C, Gallar, J, Meseguer, V and Binshtok, A
Publicada:
1 ene 2021
Ahead of Print:
6 ene 2021
Resumen:
Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the sensory transduction of pain-producing stimuli, yet the vast majority of our knowledge about sensory TRP channel function is limited to data obtained from in vitro models which do not necessarily reflect physiological conditions. In recent years, the development of novel optical methods such as genetically encoded calcium indicators and photo-modulation of ion channel activity by pharmacological tools has provided an invaluable opportunity to directly assess nociceptive TRP channel function at the nerve terminal.
Filiaciones:
Aleixandre-Carrera, F:
Univ Miguel Hernandez CSIC, Inst Neurociencias, Alacant 03550, Spain
Engelmayer, N:
Hebrew Univ Jerusalem, Hadassah Med Sch, Inst Med Res Israel Canada, Dept Med Neurobiol, IL-91123 Jerusalem, Israel
Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, IL-9190401 Jerusalem, Israel
Ares-Suarez, D:
Univ Miguel Hernandez CSIC, Inst Neurociencias, Alacant 03550, Spain
Acosta, M:
Univ Miguel Hernandez CSIC, Inst Neurociencias, Alacant 03550, Spain
Belmonte, C:
Univ Miguel Hernandez CSIC, Inst Neurociencias, Alacant 03550, Spain
:
Univ Miguel Hernandez CSIC, Inst Neurociencias, Alacant 03550, Spain
Inst Invest Sanitaria & Biomed Alicante, Alacant 03550, Spain
Meseguer, V:
Univ Miguel Hernandez CSIC, Inst Neurociencias, Alacant 03550, Spain
Binshtok, A:
Hebrew Univ Jerusalem, Hadassah Med Sch, Inst Med Res Israel Canada, Dept Med Neurobiol, IL-91123 Jerusalem, Israel
Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, IL-9190401 Jerusalem, Israel
Green Published
|