The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2
Por:
Caballero-Garcia, A, Noriega, D, Bello, H, Roche, E and Cordova-Martinez, A
Publicada:
1 dic 2021
Resumen:
Vaccines are the only way to reduce the morbidity associated to SARS-CoV-2 infection. The appearance of new mutations urges us to increase the effectiveness of vaccines as a complementary alternative. In this context, the use of adjuvant strategies has improved the effectiveness of different vaccines against virus infections such as dengue, influenza, and common cold. Recent reports on patients infected by COVID-19 reveal that low levels of circulating vitamin D correlate with a severe respiratory insufficiency. The immunomodulatory activity of this micronutrient attenuates the synthesis of pro-inflammatory cytokines and at the same time, increases antibody production. Therefore, the present review proposes the use of vitamin D as adjuvant micronutrient to increase the efficacy of vaccines against SARS-CoV-2 infection.
Filiaciones:
Caballero-Garcia, A:
Hlth Sci Fac, GIR Phys Exercise & Aging, Dept Anat & Radiol, Campus Univ Los Pajaritos, Soria 42004, Spain
Noriega, D:
Univ Valladolid, Valladolid Univ Hosp, Spine Dept, Valladolid 47005, Spain
Bello, H:
Sch Forestry Ind & Agron Engn & Bioenergy, Dept Math, GIR Phys Exercise & Aging, Campus Univ Los Pajaritos, Soria 42004, Spain
:
Univ Miguel Hernandez, Inst Bioengn, Dept Appl Biol Nutr, Elche 03202, Spain
Inst Salud Carlos III ISCIII, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain
Cordova-Martinez, A:
Univ Valladolid, Fac Hlth Sci, GIR Phys Exercise & Aging, Dept Biochem Mol Biol & Physiol, Campus Univ Los Pajaritos, Soria 42004, Spain
gold, Green Published
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