Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data.
Por:
Giorgi-Pierfranceschi M, Monreal M, Di Micco P, Francisco I, Hernández-Blasco L, Madridano O, López-Sáez JB, Hernando E, Meireles J, Dentali F and The Riete Investigators
Publicada:
15 feb 2022
Ahead of Print:
15 feb 2022
Resumen:
Background and Objectives: The influence of smoking habits on mortality, VTE recurrence, and major bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Materials and Methods: We used data from the RIETE (Registro Enfermedad TromboEmbólica) registry to compare mortality, VTE recurrence, and major bleeding risk in smoking versus non-smoking patients with acute VTE. Results: 50,881 patients (43,426 non-smoking and 7455 smoking patients) were included. After a median follow-up of 8.8 months, 7110 patients died (fatal PE 292 and fatal bleeding 281), 3243 presented VTE recurrence, and 1579 had major bleeding. At multivariate analysis, smoking behavior was associated with a higher hazard of death, (HR: 1.28; 95% CI: 1.19-1.40). The risk of VTE recurrence was marginally increased in smoking patients compared to non-smoking patients (1.14; 95% CI: 1.02-1.27). Major bleeding did not differ in smoking and non-smoking patients (1.15; 95% CI: 0.96-1.38). The presence of cancer did not appear to influence the association between smoking habits and death (HR: 1.34; 95% CI: 1.22-1.47 in cancer patients and HR: 1.23; 95% CI: 1.04, 1.45 in non-cancer patients, respectively) Conclusions: the risk of death after an acute episode of VTE appeared to be higher in smoking than in non-smoking patients and this risk is higher between patients presenting PE at the onset of symptoms.
Filiaciones:
Giorgi-Pierfranceschi M:
Department of Internal Medicine, Istituti Ospitalieri di Cremona, 26100 Cremona, Italy
Monreal M:
Department of Internal Medicine, Hospital Germans Trias i Pujol, Universidad Católica de Murcia, 08016 Barcelona, Spain
Di Micco P:
Department of Internal Medicine and Emergency Room, Ospedale Buon Consiglio Fatebenefratelli, 80122 Naples, Italy
Francisco I:
Department of Internal Medicine, Hospital Universitari de Girona Dr. Josep Trueta, 17007 Gerona, Spain
:
Department of Pneumonology, Hospital General Universitario de Alicante, ISABIAL, UMH, 03014 Alicante, Spain
Madridano O:
Department of Internal Medicine, Hospital Universitario Infanta Sofía, 28042 Madrid, Spain
López-Sáez JB:
Department of Internal Medicine, Hospital Universitario de Puerto Real, 11006 Cádiz, Spain
Hernando E:
Department of Pneumonology, Hospital San Pedro, 26001 Logroño, Spain
Meireles J:
Department of Internal Medicine, Centro Hospitalar de Entre o Douro e Vouga, 4520-195 Santa María da Feira, Portugal
Dentali F:
Department of Medicine and Surgery, Insubria University, 21100 Varese, Italy
gold, Green Published
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