Epithelial and sensory mechanisms of nasal hyperreactivity
Por:
Velasco, E, Delicado-Miralles, M, Hellings, P, Gallar, J, Van Gerven, L and Talavera, K
Publicada:
1 may 2022
Ahead of Print:
1 feb 2022
Resumen:
"Nasal hyperreactivity" is a key feature in various phenotypes of upper airway diseases, whereby reactions of the nasal epithelium to diverse chemical and physical stimuli are exacerbated. In this review, we illustrate how nasal hyperreactivity can result from at least three types of mechanisms: (1) impaired barrier function, (2) hypersensitivity to external and endogenous stimuli, and (3) potentiation of efferent systems. We describe the known molecular basis of hyperreactivity related to the functional impairment of epithelial cells and somatosensory innervation, and indicate that the thermal, chemical, and mechanical sensors determining hyperreactivity in humans remain to be identified. We delineate research directions that may provide new insights into nasal hyperreactivity associated with rhinitis/rhinosinusitis pathophysiology and therapeutics. The elucidation of the molecular mechanisms underlying nasal hyperreactivity is essential for the treatment of rhinitis according to the precepts of precision medicine.
Filiaciones:
Velasco, E:
Univ Miguel Hernandez, CSIC, Inst Neurociencias, Alacant, Spain
European Univ Brain & Technol Neurotech EU, Alacant, Spain
:
Univ Miguel Hernandez, CSIC, Inst Neurociencias, Alacant, Spain
Hellings, P:
Univ Hosp Leuven, Dept Otorhinolaryngol, Leuven, Belgium
:
Univ Miguel Hernandez, CSIC, Inst Neurociencias, Alacant, Spain
European Univ Brain & Technol Neurotech EU, Alacant, Spain
Inst Invest Sanitaria & Biomed Alicante, Alacant, Spain
Van Gerven, L:
Univ Hosp Leuven, Dept Otorhinolaryngol, Leuven, Belgium
Katholieke Univ Leuven, Allergy & Clin Immunol Res Unit, Dept Microbiol Immunol & Transplantat, Leuven, Belgium
Katholieke Univ Leuven, Dept Neurosci Expt Otorhinolaryngol Rhinol Res, Leuven, Belgium
Talavera, K:
Katholieke Univ Leuven, VIB KU Leuven Ctr Brain & Dis Res, Dept Cellular & Mol Med, Lab Ion Channel Res, Leuven, Belgium
Bronze
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