GABA(B) receptors: modulation of thalamocortical dynamics and synaptic plasticity
Por:
Sanchez-Vives, M, Barbero-Castillo, A, Perez-Zabalza, M and Reig, R
Publicada:
26 feb 2021
Ahead of Print:
1 feb 2021
Resumen:
GABA(B)-receptors (GABA(B)-Rs) are metabotropic, G protein-coupled receptors for the neurotransmitter GABA. Their activation induces slow inhibitory control of the neuronal excitability mediated by pre- and postsynaptic inhibition. Presynaptically GABA(B)-Rs reduce GABA and glutamate release inhibiting presynaptic Ca2+ channels in both inhibitory and excitatory synapses while postsynaptic GABA(B)-Rs induce robust slow hyperpolarization by the activation of K+ channels. GABA(B)-Rs are activated by non-synaptic or volume transmission, which requires high levels of GABA release, either by the simultaneous discharge of GABAergic interneurons or very intense discharges in the thalamus or by means of the activation of a neurogliaform interneurons in the cortex. The main receptor subunits GABA(B1a), GABA(B1b) and GABA(B2) are strongly expressed in neurons and glial cells throughout the central nervous system and GABA(B)-R activation is related to many neuronal processes such as the modulation of rhythmic activity in several brain regions. In the thalamus, GABA(B)-Rs modulate the generation of the main thalamic rhythm, spindle waves. In the cerebral cortex, GABA(B)-Rs also modulate the most prominent emergent oscillatory activity-slow oscillations-as well as faster oscillations like gamma frequency. Further, recent studies evaluating the complexity expressed by the cortical network, a parameter associated with consciousness levels, have found that GABA(B)-Rs enhance this complexity, while their blockade decreases it. This review summarizes the current results on how the activation of GABA(B)-Rs affects the interchange of information between brain areas by controlling rhythmicity as well as synaptic plasticity. (c) 2020 IBRO. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Filiaciones:
Sanchez-Vives, M:
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain
Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain
Barbero-Castillo, A:
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain
Perez-Zabalza, M:
Univ Zaragoza, Biomed Signal Interpretat & Computat Simulat Grp, Zaragoza, Spain
:
Inst Neurociencias Alicante, Alicante, Spain
Green Published, hybrid
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