Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks
Por:
Lopez-Madrona, V, Perez-Montoyo, E, Alvarez-Salvado, E, Moratal, D, Herreras, O, Pereda, E, Mirasso, C and Canals, S
Publicada:
20 jul 2020
Resumen:
Hippocampal firing is organized in theta sequences controlled by internal memory processes and by external sensory cues, but how these computations are coordinated is not fully understood. Although theta activity is commonly studied as a unique coherent oscillation, it is the result of complex interactions between different rhythm generators. Here, by separating hippocampal theta activity in three different current generators, we found epochs with variable theta frequency and phase coupling, suggesting flexible interactions between theta generators. We found that epochs of highly synchronized theta rhythmicity preferentially occurred during behavioral tasks requiring coordination between internal memory representations and incoming sensory information. In addition, we found that gamma oscillations were associated with specific theta generators and the strength of theta-gamma coupling predicted the synchronization between theta generators. We propose a mechanism for segregating or integrating hippocampal computations based on the flexible coordination of different theta frameworks to accommodate the cognitive needs.
Filiaciones:
Lopez-Madrona, V:
Univ Miguel Hernandez, Inst Neurociencias, CSIC, Alacant, Spain
Perez-Montoyo, E:
Univ Miguel Hernandez, Inst Neurociencias, CSIC, Alacant, Spain
Alvarez-Salvado, E:
Univ Miguel Hernandez, Inst Neurociencias, CSIC, Alacant, Spain
Moratal, D:
Univ Politecn Valencia, Ctr Biomat & Ingn Tisular, Valencia, Spain
Herreras, O:
CSIC, Inst Cajal, Madrid, Spain
Pereda, E:
Univ La Laguna, Escuela Super Ingn & Tecnol, Dept Ingn Ind, San Cristobal la Laguna, Spain
Univ La Laguna, Escuela Super Ingn & Tecnol, IUNE, San Cristobal la Laguna, Spain
Ctr Biomed Technol, Lab Cognit & Computat Neurosci, Madrid, Spain
Mirasso, C:
IFISC CSIC UIB, Inst Fis Interdisciplinar & Sistemas Complejos, Campus Univ Illes Balears, Palma De Mallorca, Spain
:
Univ Miguel Hernandez, Inst Neurociencias, CSIC, Alacant, Spain
Green Published, gold, Green Submitted
|