Guidelines and definitions for research on epithelial-mesenchymal transition
Por:
Yang, J, Antin, P, Berx, G, Blanpain, C, Brabletz, T, Bronner, M, Campbell, K, Cano, A, Casanova, J, Christofori, G, Dedhar, S, Derynck, R, Ford, H, Fuxe, J, de Herreros, A, Goodall, G, Hadjantonakis, A, Huang, R, Kalcheim, C, Kalluri, R, Kang, Y, Khew-Goodall, Y, Levine, H, Liu, J, Longmore, G, Mani, S, Massague, J, Mayor, R, McClay, D, Mostov, K, Newgreen, D, Nieto, M, Puisieux, A, Runyan, R, Savagner, P, Stanger, B, Stemmler, M, Takahashi, Y, Takeichi, M, Theveneau, E, Thiery, J, Thompson, E, Weinberg, R, Williams, E, Xing, J, Zhou, B, Sheng, G and Emt Int Assoc TEMTIA
Publicada:
1 jun 2020
Resumen:
Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.
In this Consensus Statement, the authors (on behalf of the EMT International Association) propose guidelines to define epithelial-mesenchymal transition, its phenotypic plasticity and the associated multiple intermediate epithelial-mesenchymal cell states. Clarification of nomenclature and definitions will help reduce misinterpretation of research data generated in different experimental model systems and promote cross-disciplinary collaboration.
Filiaciones:
Yang, J:
Univ Calif San Diego, Moores Canc Ctr, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, Dept Pediat, La Jolla, CA 92093 USA
Antin, P:
Univ Arizona, Dept Cellular & Mol Med, Tucson, AZ USA
Berx, G:
Univ Ghent, Mol & Cellular Oncol Lab, Dept Biomed Mol Biol, Canc Res Inst Ghent CRIG,VIB Ctr Inflammat Res, Ghent, Belgium
Blanpain, C:
Univ Libre Bruxelles, Lab Stem Cells & Canc, Brussels, Belgium
Brabletz, T:
Friedrich Alexander Univ Erlangen Nurnberg, Dept Expt Med 1, Nikolaus Fiebiger Ctr Mol Med, Erlangen, Germany
Bronner, M:
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA
Campbell, K:
Univ Sheffield, Dept Biomed Sci, Sheffield, S Yorkshire, England
Univ Sheffield, Bateson Ctr, Sheffield, S Yorkshire, England
Cano, A:
UAM, Dept Bioquim, Inst Invest Biomed Alberto Sols, CSIC,IdiPAZ, Madrid, Spain
Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain
Casanova, J:
Inst Biol Mol Barcelona IBMB CSIC, IRB, Barcelona Inst Sci & Technol, Barcelona, Spain
Christofori, G:
Univ Basel, Dept Biomed, Basel, Switzerland
Dedhar, S:
Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC, Canada
British Columbia Canc Res Ctr, Vancouver, BC, Canada
Derynck, R:
Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
Ford, H:
Univ Colorado, Dept Pharmacol, Anschutz Med Campus, Aurora, CO USA
Fuxe, J:
Karolinska Univ Hosp, Dept Lab Med LABMED, Div Pathol, Stockholm, Sweden
Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Stockholm, Sweden
de Herreros, A:
Univ Pompeu Fabra, Programa Recerca Canc, Inst Hosp Mar Invest Med IMIM, Barcelona, Spain
Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain
Goodall, G:
Alliance SA Pathol, Ctr Canc Biol, Adelaide, SA, Australia
Univ South Australia, Adelaide, SA, Australia
Hadjantonakis, A:
Mem Sloan Kettering Canc Ctr, Dev Biol Program, 1275 York Ave, New York, NY 10021 USA
Huang, R:
Natl Taiwan Univ, Coll Med, Sch Med, Taipei, Taiwan
Kalcheim, C:
Hebrew Univ Jerusalem, Dept Med Neurobiol, Inst Med Res Israel Canada, Hadassah Med Sch, Jerusalem, Israel
Hebrew Univ Jerusalem, Safra Ctr Neurosci, Hadassah Med Sch, Jerusalem, Israel
Kalluri, R:
Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Metastasis Res Ctr, Houston, TX 77030 USA
Kang, Y:
Princeton Univ, Dept Mol Biol, Princeton, NJ USA
Khew-Goodall, Y:
Alliance SA Pathol, Ctr Canc Biol, Adelaide, SA, Australia
Univ South Australia, Adelaide, SA, Australia
Levine, H:
Northeastern Univ, Dept Phys, Boston, MA 02115 USA
Liu, J:
Univ Texas MD Anderson Canc Ctr, Dept Anat Pathol, Div Pathol & Lab Med, Houston, TX 77030 USA
Longmore, G:
Washington Univ, Dept Med Oncol, St Louis, MO 63110 USA
Washington Univ, Dept Cell Biol & Physiol, ICCE Inst, St Louis, MO 63110 USA
Mani, S:
Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA
Massague, J:
Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA
Mayor, R:
UCL, Dept Cell & Dev Biol, London, England
McClay, D:
Duke Univ, Dept Biol, Durham, NC USA
Mostov, K:
Univ Calif San Francisco, Sch Med, Dept Anat, San Francisco, CA USA
Univ Calif San Francisco, Sch Med, Dept Biochem, San Francisco, CA USA
Univ Calif San Francisco, Sch Med, Dept Biophys, San Francisco, CA USA
Newgreen, D:
Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic, Australia
:
Inst Neurociencias CSIC UMH, Avda Ramon y Cajal S-N, Sant Joan Dalacant, Spain
Puisieux, A:
Univ Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Ctr Leon Berard,Canc Res Ctr Lyon, Lyon, France
PSL Res Univ, Inst Curie, Paris, France
Runyan, R:
Univ Arizona, Dept Cellular & Mol Med, Tucson, AZ USA
Savagner, P:
Univ Paris Saclay, INSERM, Integrat Tumor Immunol & Genet Oncol, Gustave Roussy,UMR 1186, Villejuif, France
Stanger, B:
Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA
Stemmler, M:
Friedrich Alexander Univ Erlangen Nurnberg, Dept Expt Med 1, Nikolaus Fiebiger Ctr Mol Med, Erlangen, Germany
Takahashi, Y:
Kyoto Univ, Grad Sch Sci, Dept Zool, Kyoto, Japan
Takeichi, M:
RIKEN Ctr Biosyst Dynam Res, Kobe, Hyogo, Japan
Theveneau, E:
Univ Toulouse, CNRS, CBI, CBD,UPS, Toulouse, France
Thiery, J:
Guangzhou Regenerat Med & Hlth, Guangdong Lab, Guangzhou, Peoples R China
Thompson, E:
Queensland Univ Technol, Sch Biomed Sci, Translat Res Inst, Woolloongabba, Qld, Australia
Queensland Univ Technol, Inst Hlth & Biomed Innovat, Translat Res Inst, Woolloongabba, Qld, Australia
Weinberg, R:
MIT, Whitehead Inst Biomed Res, Dept Biol, Ludwig Ctr Mol Oncol, Cambridge, MA USA
Williams, E:
Queensland Univ Technol, APCRC Q, Woolloongabba, Qld, Australia
Queensland Univ Technol, QBCI, Sch Biomed Sci, Woolloongabba, Qld, Australia
Queensland Univ Technol, Inst Hlth & Biomed Innovat, Woolloongabba, Qld, Australia
Xing, J:
Univ Pittsburgh, Dept Computat & Syst Biol, Pittsburgh, PA USA
Univ Pittsburgh, UPMC Hillman Canc Ctr, Pittsburgh, PA USA
Zhou, B:
Univ Kentucky, Coll Med, Dept Mol & Cellular Biochem, Lexington, KY USA
Univ Kentucky, Coll Med, UK Markey Canc Ctr, Lexington, KY USA
Sheng, G:
Kumamoto Univ, IRCMS, Kumamoto, Japan
Green Published, hybrid, Green Accepted
|