Dietary Patterns in Pregnancy and Biomarkers of Oxidative Stress in Mothers and Offspring: The NELA Birth Cohort.
Por:
Morales E, García-Serna AM, Larqué E, Sánchez-Campillo M, Serrano-Munera A, Martinez-Graciá C, Santaella-Pascual M, Suárez-Martínez C, Vioque J, Noguera-Velasco JA, Avilés-Plaza FV, Martínez-Villanueva M, Ballesteros-Meseguer C, Galdo-Castiñeira L and García-Marcos L
Publicada:
12 abr 2022
Ahead of Print:
12 abr 2022
Resumen:
BACKGROUND: Although adherence to the Mediterranean and antioxidant-rich diets during pregnancy is suggested to improve maternal-fetal health by reducing oxidative stress, yet there is no study available. OBJECTIVE: We examined whether maternal dietary patterns in pregnancy impact the biomarkers of oxidative stress in mothers and their offspring. METHODS: Study population included 642 mothers and 335 newborns of the "Nutrition in Early Life and Asthma" (NELA) birth cohort. Maternal diet during pregnancy was assessed by a validated food frequency questionnaire and a priori-defined dietary indices (relative Mediterranean Diet [rMED], alternative Mediterranean Diet [aMED], Dietary Approach to Stop Hypertension [DASH], Alternate Healthy Index [AHEI], and AHEI-2010) were calculated. Biomarkers measured were: hydroperoxides, carbonyl groups, and 8-hydroxydeoxyguanosine (8OHdG) determined in maternal blood and newborn cord blood, and urinary maternal and offspring 15-F2t-isoprostane. Multivariate linear regression models were performed. RESULTS: Maternal rMED score was inversely associated with the maternal levels of 8OHdG at mid-pregnancy (beta per 1-point increase = -1.61; 95% CI -2.82, -0.39) and the newborn levels of hydroperoxides (beta per 1-point increase = -4.54; 95% CI -9.32, 0.25). High vs. low maternal rMED score was marginally associated with the decreased levels of 8OHdG in newborns (beta = -9.17; 95% CI -19.9, 1.63; p for trend 0.079). Maternal DASH score tended to be inversely associated with maternal urinary 15-F2t-isoprostane (beta per 1-point increase = -0.69; 95% CI, -1.44, 0.06). High vs. low maternal AHEI score was associated with reduced offspring urinary levels of 15-F2t-isoprostane (beta = -20.2; 95% CI -38.0, -2.46; p for trend 0.026). CONCLUSION: These results suggest that maternal adherence to healthy dietary patterns during pregnancy may reduce DNA damage and lipid oxidation in mothers and offspring.
Filiaciones:
Morales E:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Department of Public Health Sciences, Faculty of Medicine, University of Murcia, Murcia, Spain
García-Serna AM:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, Murcia, Spain
Larqué E:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain
Sánchez-Campillo M:
Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain
Serrano-Munera A:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Martinez-Graciá C:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain
Santaella-Pascual M:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain
Suárez-Martínez C:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain
:
Health and Biomedical Research Institute of Alicante, University Miguel Hernandez (ISABIAL-UMH), Alicante, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Noguera-Velasco JA:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Molecular Therapy and Biomarkers Research Group, Clinical Analysis Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain
Avilés-Plaza FV:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Molecular Therapy and Biomarkers Research Group, Clinical Analysis Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain
Martínez-Villanueva M:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Molecular Therapy and Biomarkers Research Group, Clinical Analysis Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain
Ballesteros-Meseguer C:
Obstetrics & Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain
Galdo-Castiñeira L:
Obstetrics & Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain
García-Marcos L:
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain
Paediatric Allergy and Pulmonology Units, Virgen de la Arrixaca University Children's Hospital, University of Murcia, Murcia, Spain
ARADyAL Allergy Network, Madrid, Spain
Green Published, gold
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