OSDI Questions on Daily Life Activities Allow to Detect Subclinical Dry Eye in Young Contact Lens Users
Por:
Pastor-Zaplana, J, Borras, F, Gallar, J and Acosta, M
Publicada:
1 may 2022
Ahead of Print:
6 may 2022
Resumen:
Dry eye disease (DED) is difficult to detect in young contact lens (CL) wearers, who usually have no signs, mild symptoms and an ocular surface disease index (OSDI) below the DED diagnosis values (OSDI >= 13). We investigate if some of the 12 OSDI questions (OSDI A-ocular symptoms; OSDI B-vision-related functionality; OSDI C-environmental triggers) contribute the most to classify young CL as symptomatic. TBUT and tear volume are also measured. Age, gender and refraction error-matched eye glasses (EG) wearers participated as the control. CL and EG data were compared with t-test and z-test. Confusion matrices and logistic correlation analyses were performed to define the contribution of each OSDI question to classify symptomatic subjects. OSDI classified symptomatic CL better than the tear volume or TBUT values. In CL, only OSDI B and C values were significantly higher in symptomatic vs. asymptomatic subjects (p < 0.001), while values of all twelve OSDI questions were significantly higher in symptomatic vs. asymptomatic EG (p < 0.05-0.001). All OSDI questions contribute equally to identify symptomatic EG, while only OSDI B questions on daily life visual functions are significant to classify symptomatic CL wearers at risk to develop DED or at a subclinical stage. CL wearers scoring >= 2 on the OSDI B questions should be considered for preventive treatments, even if their clinical sings are scarce or absent.
Filiaciones:
:
Univ Miguel Hernandez, Inst Neurociencias, CSIC, Sant Joan dAlacant 03550, Spain
Univ Miguel Hernandez, Dept Patol & Cirugia, Sant Joan dAlacant 03550, Spain
:
Univ Miguel Hernandez, Dept Estadist Matemat & Informat, Sant Joan dAlacant 03550, Spain
:
Univ Miguel Hernandez, Inst Neurociencias, CSIC, Sant Joan dAlacant 03550, Spain
Inst Invest Biomed & Sanitaria Alicante, Alicante 03010, Spain
:
Univ Miguel Hernandez, Inst Neurociencias, CSIC, Sant Joan dAlacant 03550, Spain
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