Hepatitis C Hospitalizations in Spain and Impact of New Curative Antiviral Therapies.
Por:
Ramos-Rincon JM, Pinargote-Celorio H, de Mendoza C, Ramos-Belinchón C, Barreiro P, Gómez-Gallego F, Corral O and Soriano V
Publicada:
1 sep 2022
Ahead of Print:
29 may 2022
Resumen:
Chronic hepatitis C virus (HCV) infection is major cause of decompensated cirrhosis and liver cancer. The advent of curative new antiviral therapies since year 2015 has dramatically improved the prognosis of HCV patients. The real-life clinical benefits at country level of these therapies have not yet been assessed. This is a retrospective study of all hospitalizations in Spain including HCV as diagnosis using the Spanish National Registry of Hospital Discharges. Information was retrieved from 1997 to 2019. From 81,482,509 nationwide hospital admissions recorded during the study period, 1,057,582 (1.29%) included HCV as diagnosis. The median age of HCV hospitalized patients was 54-years-old. Males accounted for 63.2% of cases. Most HCV admissions recorded chronic hepatitis C whereas acute hepatitis C was reported in less than 3%. In-hospital death occurred in 6.4% of HCV admissions. Coinfection with HIV or hepatitis B virus was seen in 14.8% and 6.4%, respectively. Patients hospitalized with HIV-HCV coinfection represented 14.8% of cases and were on average 17 years younger than HCV-monoinfected individuals. The rate of HCV hospitalizations significantly increased until 2005, and then stabilized for one decade. A significant reduction was noticed since 2015. However, whereas the proportion of HCV-associated hepatic decompensation events declined since then, liver cancer diagnoses increased. In conclusion, hospital admissions of HCV individuals significantly declined in Spain since 2015 following a wide prescription of new oral direct-acting antivirals. This reduction was primarily driven by a fall of hepatic decompensation events whereas HCV-related liver cancer continues rising.
Filiaciones:
:
Internal Medicine Department, General University Hospital of Alicante-ISABIAL & Miguel Hernández University of Elche, Alicante, Spain
:
Internal Medicine Department, General University Hospital of Alicante-ISABIAL & Miguel Hernández University of Elche, Alicante, Spain
de Mendoza C:
Laboratory of Internal Medicine, Puerta de Hierro Research Institute & University Hospital, Madrid, Spain
Ramos-Belinchón C:
Gastroenterology Department, Gregorio Marañón University Hospital, Madrid, Spain
Barreiro P:
Public Health Laboratory, Hospital Isabel Zendal, Madrid, Spain
Gómez-Gallego F:
UNIR Health Sciences School & Medical Center, Madrid, Spain
Corral O:
UNIR Health Sciences School & Medical Center, Madrid, Spain
:
UNIR Health Sciences School & Medical Center, Madrid, Spain
Green Published
|