Benefits of SGLT2i for the Treatment of Heart Failure Irrespective of Diabetes Diagnosis: A State-of-the-Art Review.
Por:
Delgado E, Jódar E, Mezquita-Raya P and Moreno-Pérez Ó
Publicada:
1 jul 2022
Ahead of Print:
15 jun 2022
Resumen:
Morbidity and mortality associated with heart failure (HF) has remained high despite advances in therapy. Furthermore, HF-associated risk in patients with type 2 diabetes mellitus (T2D) is even higher than in patients without T2D owing to the strong reciprocal relationship between conditions. However, until recently, no therapy to treat patients with diabetes also reduced cardiovascular risks related to HF. Recent clinical studies (DAPA-HF, EMPEROR-Reduced and EMPEROR-Preserved, SOLOIST-WHF trial) and meta-analysis have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) are among the first antidiabetic drugs capable of reducing cardiovascular risks related to HF and improving the prognosis of patients with and without diabetes. Their pleiotropic mechanisms of action place them at the intersection of hemodynamic, metabolic, and neurohumoral pathways, with clear advantages for treating these patients independent of its glucose-lowering effect. Moreover, the benefits of SGLT2i were consistent across the cardiorenal continuum in different populations and clinical settings, which has led to different guidelines introducing SGLT2i as a first-line treatment for HF.
Filiaciones:
Delgado E:
Department of Medicine, University of Oviedo, Oviedo, Spain
Endocrinology and Nutrition Service, Central University Hospital of Asturias (HUCA), Oviedo, Spain
Spanish Biomedical Research Network in Rare Diseases (CIBERER), Madrid, Spain
Health Research Institute of Asturias (ISPA), Oviedo, Spain
Jódar E:
Endocrinology and Clinical Nutrition Department, University Hospital Quiron Salud Madrid, Universidad Europea, Madrid, Spain
Mezquita-Raya P:
Endocrinology and Nutrition Service, Torrecárdenas University Hospital, Almería, Spain
Biomedical Research Unit, Torrecárdenas University Hospital, Almería, Spain
:
Endocrinology and Nutrition Department, Alicante General University Hospital, Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.
Clinical Medicine Department, Miguel Hernández University, Elche, Spain.
gold, Green Published
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